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Frequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohort

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datacite.rightshttp://purl.org/coar/access_right/c_abf2
dc.contributor.authorNieto, Romina
dc.contributor.authorHernández, Lucia
dc.contributor.authorScolnik, Marina
dc.contributor.authorMaurelli, Laura
dc.contributor.authorGobbi, Carla
dc.contributor.authorSaurit, Veronica
dc.contributor.authorGarcia, Lucila
dc.contributor.authorKisluk, Boris
dc.contributor.authorBertolaccini, Maria Constanza
dc.contributor.authorSerna Gongora, Melissa Brenda
dc.contributor.authorGómez, Graciela N
dc.contributor.authorPisoni, Cecilia
dc.contributor.authorRalle, Ana Carolina
dc.contributor.authorPirruccio, Paola
dc.contributor.authorde Souza Barbosa, Vitalina
dc.contributor.authorGasparin, Andrese
dc.contributor.authorDuarte, Angela
dc.contributor.authorAlves Alvino, Laíssa Cristina
dc.contributor.authorBorba, Eduardo F
dc.contributor.authorBonfá, Eloisa
dc.contributor.authorTorres dos Reis Neto, Edgard
dc.contributor.authorBondi Peralta, Alexis
dc.contributor.authorMassardo, Loreto
dc.contributor.authorAroca-Martinez, Gustavo
dc.contributor.authorIglesias Gamarra, Antonio
dc.contributor.authorCañas, Carlos A
dc.contributor.authorQuintana López, Gerardo
dc.contributor.authorFrederick Silvery, Leon
dc.contributor.authorMaximiliano Martinez, Jose
dc.contributor.authorSánchez-Briones, Reyna
dc.contributor.authorPérez Cristóbal, Mario
dc.contributor.authorMartín-Nares, Eduardo
dc.contributor.authorSilveira, Luis H
dc.contributor.authorGarcía De La Torre, Ignacio
dc.contributor.authorRamírez Sánchez, Julio César
dc.contributor.authorEsquivel-Valerio, Jorge Antonio
dc.contributor.authorLosanto, Jhonatan
dc.contributor.authorVazquez, Marcos Aurelio
dc.contributor.authorAlva Linares, Magaly
dc.contributor.authorUgarte-Gil, Manuel Francisco
dc.contributor.authorCalvo-Quiroz, Armando
dc.contributor.authorPolanco, Teresandris
dc.contributor.authorPizzarossa, Carina
dc.contributor.authorSilveira, Gonzalo
dc.contributor.authorPons-Estel, Bernardo
dc.contributor.authorAlarcon, Graciela S
dc.contributor.authorPons-Estel, Guillermo
dc.date.accessioned2026-03-27T20:37:38Z
dc.date.available2026-03-27T20:37:38Z
dc.date.issued2026
dc.description.abstractObjective The aim of this study was to assess the epidemiological and clinical characteristics of herpes zoster (HZ) and to identify the factors associated with its first episode in Latin American SLE patients. Methods GLADEL 2.0 (Grupo Latino Americano De Estudio del Lupus) is a multiethnic, Latin American observational cohort of SLE patients. Demographic, clinical, laboratory, treatment and disease activity/damage data were compared between patients with and without HZ; its prevalence was assessed at cohort entry, incidence rates of first and recurrent HZ infections were calculated based on person-years of follow-up. Logistic regression was used to identify factors associated with HZ events, while Cox regression was used to determine the variables associated with time to first event. Results Among 1083 SLE patients, the HZ cumulative incidence after its diagnosis was 11.5%, with a prevalence of 8.6% at cohort entry. During 5-year of follow-up, the incidence of HZ was 2.9% and 16.8% patients had recurrent episodes. Patients with HZ showed higher frequencies of alopecia, psychosis and seizures, along with higher disease activity, damage accrual, proteinuria and higher daily prednisone doses prior to the event. Multivariate analyses identified female sex, higher SLE Disease Activity Index 2000 (SLEDAI-2K) and higher daily prednisone dose as independent predictors of HZ occurrence. Older age at diagnosis, psychosis, disease activity and a higher daily prednisone dose were associated with a shorter time to HZ onset. Conclusion In the GLADEL 2.0 cohort, the high burden of HZ in SLE, together with its association with active disease, corticosteroid exposure and neuropsychiatric manifestations, underscores the need for proactive risk stratification in clinical practice.eng
dc.format.mimetypepdf
dc.identifier.citationNieto R, Hernández L, Scolnik M, et al. Frequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohort. Lupus Science & Medicine 2026;13:e001877. doi:10.1136/lupus-2025-001877eng
dc.identifier.doihttps://doi. org/10. 1136/lupus-2025-001877
dc.identifier.issn20538790 (electrónico)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/17481
dc.identifier.urlhttps://lupus.bmj.com/content/13/1/e001877
dc.language.isoeng
dc.publisherBMJ Groupspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceLupus Science & Medicineeng
dc.sourceVol. 13 No. 1 Año 2026 spa
dc.titleFrequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohorteng
dc.type.driverinfo:eu-repo/semantics/article
dc.type.spaArtículo científico
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