Desarrollo de un enjuague bucal concentrado a base de Cloruro de Cetilpiridino
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Fecha
2024
Autores
Cárcamo Gulloso, Jair Arley
Reales Herrera, Elkin Antonio
Machado Ferrer, Andrés Camilo
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias Básicas y Biomédicas
Facultad de Ciencias Básicas y Biomédicas
Resumen
El cuidado bucal es fundamental para mantener una buena salud oral y prevenir enfermedades periodontales. Los enjuagues bucales juegan un papel importante como complemento a la higiene dental diaria. Uno de los ingredientes activos comunes en los enjuagues bucales es el cloruro de cetilpiridinio (CPC), un agente antimicrobiano de amplio espectro que ha demostrado eficacia en la reducción de la placa bacteriana y la prevención de la gingivitis. En este estudio se desarrolla un enjuague bucal concentrado y de fácil portabilidad usando como componente principal de la formulación CPC. También, se busca evaluar la eficacia en la inhibición del crecimiento de microorganismos de la flora oral y la aceptación por parte de consumidores aleatorios. Para la formulación del enjuague bucal se usaron como componentes: mentol cristal, glicerina, edulcorantes y otros ingredientes que mejoraron la estabilidad y el sabor del producto y contribuyeron a su eficacia y a sus características organolépticas. El enjuague bucal presentó características fisicoquímicas óptimas, como un pH de 5.7 y una densidad de 0.96 g/mL. Las pruebas de inhibición del crecimiento de la flora oral demostraron que todas las concentraciones evaluadas (0.25%, 0.5% y 0.7%) fueron efectivas en la inhibición del crecimiento de la flora oral, comparándose con un enjuague bucal comercial usado como control positivo. Sin embargo, se observó que la concentración de CPC (8%) en la formulación podría ser superior a la necesaria para lograr el efecto antimicrobiano deseado. La evaluación de la aceptación por parte de los consumidores mostró que el enjuague bucal es aceptado y acogido para su uso diario. Los resultados obtenidos muestran que el enjuague bucal concentrado a base de CPC inhibe el crecimiento de microorganismos asociados a la flora oral y que presenta características organolépticas que le proporcionan aceptabilidad por parte de los posibles consumidores.
Oral care is essential for maintaining good oral health and preventing periodontal diseases. Mouthwashes play a significant role as a complement to daily dental hygiene. One of the common active ingredients in mouthwashes is cetylpyridinium chloride (CPC), a broad-spectrum antimicrobial agent that has demonstrated efficacy in reducing bacterial plaque and preventing gingivitis. This study develops a concentrated and portable mouthwash using CPC as the main component of the formulation. Additionally, it aims to evaluate its effectiveness in inhibiting the growth of microorganisms in the oral flora and its acceptance among random consumers. The mouthwash formulation includes components such as menthol crystals, glycerin, sweeteners, and other ingredients that enhance the product's stability, flavor, efficacy, and organoleptic characteristics. The mouthwash exhibited optimal physicochemical properties, such as a pH of 5.7 and a density of 0.96 g/mL. Growth inhibition tests of oral flora demonstrated that all evaluated concentrations (0.25%, 0.5%, and 0.7%) effectively inhibited the growth of oral microorganisms, comparable to a commercial mouthwash used as a positive control. However, it was observed that the CPC concentration (8%) in the formulation might exceed what is necessary to achieve the desired antimicrobial effect.Consumer acceptance evaluation revealed that the mouthwash is well-received and suitable for daily use. The results indicate that the concentrated CPC-based mouthwash inhibits the growth of microorganisms associated with oral flora and possesses organoleptic properties that ensure acceptability among potential consumers.
Oral care is essential for maintaining good oral health and preventing periodontal diseases. Mouthwashes play a significant role as a complement to daily dental hygiene. One of the common active ingredients in mouthwashes is cetylpyridinium chloride (CPC), a broad-spectrum antimicrobial agent that has demonstrated efficacy in reducing bacterial plaque and preventing gingivitis. This study develops a concentrated and portable mouthwash using CPC as the main component of the formulation. Additionally, it aims to evaluate its effectiveness in inhibiting the growth of microorganisms in the oral flora and its acceptance among random consumers. The mouthwash formulation includes components such as menthol crystals, glycerin, sweeteners, and other ingredients that enhance the product's stability, flavor, efficacy, and organoleptic characteristics. The mouthwash exhibited optimal physicochemical properties, such as a pH of 5.7 and a density of 0.96 g/mL. Growth inhibition tests of oral flora demonstrated that all evaluated concentrations (0.25%, 0.5%, and 0.7%) effectively inhibited the growth of oral microorganisms, comparable to a commercial mouthwash used as a positive control. However, it was observed that the CPC concentration (8%) in the formulation might exceed what is necessary to achieve the desired antimicrobial effect.Consumer acceptance evaluation revealed that the mouthwash is well-received and suitable for daily use. The results indicate that the concentrated CPC-based mouthwash inhibits the growth of microorganisms associated with oral flora and possesses organoleptic properties that ensure acceptability among potential consumers.
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Palabras clave
Cloruro de cetilpiridinio, Actividad antimicrobiana, Salud oral
