Second Generation Antipsychotics (SGAs) in Schizophrenic Patients and Bipolar Disorder: Correlation With Metabolic Syndrome (NCEP ATP III(a))
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Fecha
2019
Autores
Roldan Menco, Consuelo
Díaz-Pérez, Anderson
Barrios Puerta, Zoraida
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Editor
Canadian Center of Science and Education
Resumen
Introduction: The Metabolic Syndrome is a set of diverse clinical situations such as diabetes mellitus,
hypertension and dyslipidemia. Patients with mental illnesses such as schizophrenia or bipolar disorder have a
higher mortality than the general population attributable in 60% to somatic diseases and metabolic syndrome,
where second generation antipsychotics increase the risk of weight gain and insulin resistance. Objectives.
Correlate the treatment with second generation antipsychotics (SGAs) as a possible predictor for Metabolic
Syndrome according to the NCEP ATP III (a) classification.
Methods: Descriptive, cross-sectional correlational study. The sample was of 92 patients, applying an open and
convenience sampling due to the mental state of the patients in order to determine their degree of acceptance to the
study (Informed Assent) and consent to the legal guardian as the main inclusion criterion. For the analysis, the
following variables were considered: blood pressure, weight, height, abdominal circumference, serum levels of
triglycerides, glucose and high density lipoproteins. The SPSS 20.0 ® program was used logistic regression
analysis with a p-value <0.05 and a confidence level of 95%.
Results: SGAs most used was clozapine (54.3%). The correlation analysis showed that sociodemographic aspects
such as personal history, habits, physical activity and paraclinical and anthropometric records correlated with the
possible diagnosis of metabolic syndrome (p <0.05), but not with SGAs (p> 0.05). ).
Conclusion: No correlation was found between the presence of the metabolic syndrome and the type of
antipsychotic treatment.
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Second generation antipsychotics, Schizophrenic patients, Bipolar disorder, Metabolic syndrome