Red de interacción de proteínas en la glomerulonefritis membranoproliferativa
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Fecha
2018
Autores
Polo Guerrero, María
Manotas Palacio, Lourdes
Ruiz Escorcia, Wendy
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
La glomeruonefritis membranoproliferativa es un patrón de lesión glomerular causada por diferentes patologías como el lupus eritematoso sistémicos, artritis reumatoidea, entre otro. Investigaciones previas han demostrado que en este patrón de lesión existen depósitos de proteínas del complemento tales como el factor H, factor l, properdina, C3 e inmunoglobulinas como la IgM. El propósito de este proyecto de investigación fue observar las interacciones de dichas proteínas para así poder saber si estas interacciones pueden influir en la fisiopatología del patrón de lesión. Procedimientos básicos: usando el programa MIST se construyó una red de interacción de proteínas, teniendo en cuenta las interacciones encontradas en la plataforma BioGrid. Además mediante el programa Genemanía se sacaron las interacciones físicas y genéticas de las mismas, se hallaron las islas CpG y caracterización de cada gen usando el genoma Browser.
Membranoproliferative glomeruonephritis is a pattern of glomerular injury caused by different pathologies such as systemic lupus erythematosus, rheumatoid arthritis, among others. Previous research has shown that in this injury pattern there are deposits of complement proteins such as factor H, factor l, properdin, C3 and immunoglobulins such as lgM. The purpose of this research project was to observe the interactions of these proteins in order to know if these interactions can influence the pathophysiology of the injury pattern. Basic procedures: using the MIST program, a protein interaction network was built, taking into account the interactions found in the BioGrid platform. In addition, through the Genemania program, the physical and genetic interactions were extracted, the CpG islands were found and each gene was characterized using the Browser genome.
Membranoproliferative glomeruonephritis is a pattern of glomerular injury caused by different pathologies such as systemic lupus erythematosus, rheumatoid arthritis, among others. Previous research has shown that in this injury pattern there are deposits of complement proteins such as factor H, factor l, properdin, C3 and immunoglobulins such as lgM. The purpose of this research project was to observe the interactions of these proteins in order to know if these interactions can influence the pathophysiology of the injury pattern. Basic procedures: using the MIST program, a protein interaction network was built, taking into account the interactions found in the BioGrid platform. In addition, through the Genemania program, the physical and genetic interactions were extracted, the CpG islands were found and each gene was characterized using the Browser genome.
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Palabras clave
Glomeruonefritis membranoproliferativa, C3, Properdina, Factor H, Vía alternativa del complemento, Eculizumab, Membranoproliferative glomeruonephritis, Properdin, Factor H, Alternative pathway of complement
