Hipertensión pulmonar secundaria a Sepsis en el neonato
| datacite.rights | http://purl.org/coar/access_right/c_16ec | |
| dc.contributor.advisor | Angulo García, Cesar | |
| dc.contributor.advisor | González-Torres, Henry J. | |
| dc.contributor.author | Yepes Padilla, María Patricia | |
| dc.contributor.author | Barrios Quintero, Jhony Alexander | |
| dc.date.accessioned | 2023-05-18T16:46:21Z | |
| dc.date.available | 2023-05-18T16:46:21Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | La hipertensión pulmonar es un síndrome de falla respiratoria aguda caracterizado por elevación sostenida de las resistencias vasculares pulmonares (RVP), que produce hipertensión persistente de la arteria pulmonar después del nacimiento, que ocasiona cortocircuito extrapulmonar de derecha a izquierda de sangre no oxigenada a través del conducto arterioso (CA) y foramen oval (FO) con hipoxemia severa y acidosis secundaria. La hipertensión pulmonar secundaria a sepsis (HTP-S) es una de las complicaciones de mayor preocupación en los neonatos por las implicaciones que puede conllevar a corto, media y largo plazo, algunas incluso pudiendo a comprometer la vida del niño, por los compromisos a nivel renal, cardiaco y evidentemente respiratorio. La HTP-S puede explicarse por varios mecanismos; ejemplo: gérmenes comunes en la etapa neonatal como (Streptococcus del grupo B y bacterias gramnegativas), liberan endotoxinas bacterianas desencadenando una respuesta inflamatoria secundaria, con liberación de tromboxano endotelial y de varias citoquinas (como el factor de necrosis tumoral-alfa) que lleva a un aumento en las resistencias vasculares pulmonares. Aunque la HTP es una causa frecuente de ingreso a la Unidad de Cuidados intensivos neonatales, la causa que termina en hipertensión pulmonar puede pasar desapercibida ya sea por poca asociación a la patología o por su baja frecuencia, como es el caso de la HTP secundaria a sepsis, considerada como un desafío debido a la dificultad de identificar a los recién nacidos en riesgo de sepsis, especialmente a los que tienen un buen aspecto general. | spa |
| dc.description.abstract | Pulmonary hypertension is a syndrome of acute respiratory failure characterized by sustained elevation of pulmonary vascular resistance (PVR), leading to persistent pulmonary artery hypertension after birth, leading to right-to-left extrapulmonary shunting of deoxygenated blood through the pulmonary artery. ductus arteriosus (CA) and foramen ovale (FO) with severe hypoxemia and secondary acidosis. Pulmonary hypertension secondary to sepsis (HTP-S) is one of the complications of greatest concern in neonates due to the implications that it may entail in the short, medium and long term, some of which may even compromise the life of the child, due to the commitments to renal, cardiac and obviously respiratory level. HTP-S can be explained by several mechanisms; example: common germs in the neonatal stage such as (group B Streptococcus and gram-negative bacteria), release bacterial endotoxins triggering a secondary inflammatory response, with release of endothelial thromboxane and several cytokines (such as tumor necrosis factor-alpha) that leads to an increase in pulmonary vascular resistance. Although PHT is a frequent cause of admission to the Neonatal Intensive Care Unit, the cause that ends in pulmonary hypertension may go unnoticed, either due to little association with the pathology or its low frequency, as is the case of PHT secondary to sepsis, considered a challenge due to the difficulty of identifying newborns at risk of sepsis, especially those with a good general appearance. | eng |
| dc.format.mimetype | ||
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/12414 | |
| dc.language.iso | spa | |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias de la Salud | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Hipertensión segundaria a sepsis | spa |
| dc.subject | Sepsis neonatal | spa |
| dc.subject | Unidad de cuidados intensivos neonatal | spa |
| dc.subject | Síndrome de Dificultad Respiratoria | spa |
| dc.subject | Taquipnea | spa |
| dc.subject | Mortalidad | spa |
| dc.subject | Antibiótico | spa |
| dc.subject | Resistencia antibiótica | spa |
| dc.subject | Hypertension secondary to sepsis | eng |
| dc.subject | Neonatal sepsis | eng |
| dc.subject | Neonatal intensive care unit | eng |
| dc.subject | Respiratory Distress Syndrome | eng |
| dc.subject | Tachypnea | eng |
| dc.subject | Mortality | eng |
| dc.subject | Antibiotic | eng |
| dc.subject | Antibiotic resistance | eng |
| dc.title | Hipertensión pulmonar secundaria a Sepsis en el neonato | spa |
| dc.type.driver | info:eu-repo/semantics/other | |
| dc.type.spa | Otros | |
| dcterms.references | Alrowaily N, D’Souza R, Dong S, Chowdhury S, Ryu M, Ronzoni S. Determining the optimal antibiotic regimen for chorioamnionitis: A systematic review and meta-analysis. Acta Obstet Gynecol Scand [Internet]. 2020 Nov 15; Available from: http://www.ncbi.nlm.nih.gov/pubmed/33191493 | eng |
| dcterms.references | Rafi MA, Miah MMZ, Wadood MA, Hossain MG. Risk factors and etiology of neonatal sepsis after hospital delivery: A case-control study in a tertiary care hospital of Rajshahi, Bangladesh. PLoS One [Internet]. 2020;15(11):e0242275. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33186407 | eng |
| dcterms.references | Cetinkaya M, Cekmez F, Buyukkale G, Erener-Ercan T, Demir F, Tunc T, et al. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2015 Jan;35(1):39–45. | eng |
| dcterms.references | Méndez L, Osorio O, Contreras M, García Del villar O, Vence C, Barrios K. Pulmonary sequestration an uncommon cause of persistent pulmonary hypertension in the newborn case report. Salud Uninorte. 2017 Sep;33(3):532–7. | eng |
| dcterms.references | Ward PA. What’s new in the quagmire of sepsis? Trends Mol Med. 2014 Apr;20(4):189–90. | eng |
| dcterms.references | Wu I-H, Tsai M-H, Lai M-Y, Hsu L-F, Chiang M-C, Lien R, et al. Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus. BMC Infect Dis. 2017 Dec;17(1):465. | eng |
| dcterms.references | Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017 Oct;390(10104):1770–80. | eng |
| dcterms.references | Good PI, Hooven TA. Evaluating Newborns at Risk for Early-Onset Sepsis. Pediatr Clin North Am. 2019 Apr;66(2):321–31. | eng |
| dcterms.references | Sola A, Mir R, Lemus L, Fariña D, Ortiz J. Suspected Neonatal Sepsis: Tenth Clinical Consensus of the Ibero-American Society of Neonatology (SIBEN). 2020;21(8). | eng |
| dcterms.references | Berberian G. SEPSIS NEONATAL. 2014;XXI. | spa |
| dcterms.references | Santos RP, Tristram D. A Practical Guide to the Diagnosis, Treatment, and Prevention of Neonatal Infections. Pediatr Clin North Am. 2015 Apr;62(2):491–508. | eng |
| dcterms.references | Yusef D, Shalakhti T, Awad S, Algharaibeh H, Khasawneh W. Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: A retrospective review. Pediatr Neonatol. 2018 Feb;59(1):35–41. | eng |
| dcterms.references | Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr. 2016 Apr;28(2):135–40. | eng |
| dcterms.references | Huynh B-T, Padget M, Garin B, Delarocque-Astagneau E, Guillemot D, Borand L, et al. Bacterial neonatal sepsis and antibiotic resistance in low-income countries. Lancet. 2016 Feb;387(10018):533–4. | eng |
| dcterms.references | Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018 Mar;6(3):223–30. | eng |
| dcterms.references | Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018 Jul;392(10141):75–87. | eng |
| dcterms.references | Voller SMB, Myers PJ. Neonatal Sepsis. Clin Pediatr Emerg Med. 2016 Jun;17(2):129–33. | eng |
| dcterms.references | Díaz Martín C, Marrero Pérez CL, Martín Fumero L, Torres Moreno A, de Quirós I. Early-onset Streptococcus pneumoniae-induced neonatal sepsis. Arch Bronconeumol (English Ed. 2020 Oct;56(10):671–2. | eng |
| dcterms.references | Cortese F, Scicchitano P, Gesualdo M, Filaninno A, De Giorgi E, Schettini F, et al. Early and Late Infections in Newborns: Where Do We Stand? A Review. Pediatr Neonatol. 2016 Aug;57(4):265–73. | eng |
| dcterms.references | Ferrieri P, Wallen YLD. 39 - Sepsis y meningitis en el recién nacido. Tenth Edit. Avery. Enfermedades del recién nacido. Elsevier Espa8#241;a, S.L.U.; 2019. 553–565 p. | spa |
| dcterms.references | Silva ACB, Anchieta LM, Lopes MF de P, Romanelli RM de C. Inadequate use of antibiotics and increase in neonatal sepsis caused by resistant bacteria related to health care assistance: a systematic review. Brazilian J Infect Dis. 2018 Jul;22(4):328–37. | eng |
| dcterms.references | Rappaort R, Rotem R, Rottenstreich M, Kasirer Y, Grisaru-Granovsky S, Bin-Nun A, et al. 814: Chorioamnionitis and neonatal evaluation; universal evaluation for all? Am J Obstet Gynecol. 2020 Jan;222(1):S513. | eng |
| dcterms.references | Ferreira J, Camargos PAM, Rosado V, Mourão PHO, Romanelli RM de C. Risk factors for central venous catheter-related bloodstream infection in neonates. Am J Infect Control. 2020 Sep;48(9):1102–3. | eng |
| dcterms.references | Ferreira J, Camargos PAM, Clemente WT, Romanelli RM de C. Clinical usefulness of catheter-drawn blood samples and catheter tip cultures for the diagnosis of catheter-related bloodstream infections in neonatology: A systematic review. Am J Infect Control. 2018 Jan;46(1):81–7. | eng |
| dcterms.references | Harrison GJ. Approach to infections in the fetus and newborn. Eighth Edi. Feigin and Cherry’s textbook of pediatric infectious diseases. Elsevier Inc.; 2014. 877–901 p. | eng |
| dcterms.references | Esper F. 48 - Postnatal Bacterial Infections. Eleventh E. Fanaroff and Martin’s Neonatal-Perinatal Medicine, 2-Volume Set. Elsevier Inc.; 2020. 789–808 p. | eng |
| dcterms.references | Scheel M, Perkins S. Hit or Miss? A Review of Early-Onset Sepsis in the Neonate. Crit Care Nurs Clin North Am. 2018 Sep;30(3):353–62. | eng |
| dcterms.references | Iroh Tam P-Y, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr Res. 2017 Oct;82(4):574–83. | eng |
| dcterms.references | Qiu X, Zhang L, Tong Y, Qu Y, Wang H, Mu D. Interleukin-6 for early diagnosis of neonatal sepsis with premature rupture of the membranes. Medicine (Baltimore). 2018 Nov;97(47):e13146. | eng |
| dcterms.references | Boskabadi H, Zakerihamidi M. Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review. Pediatr Neonatol. 2018 Aug;59(4):329–38. | eng |
| dcterms.references | Memar MY, Alizadeh N, Varshochi M, Kafil HS. Immunologic biomarkers for diagnostic of early-onset neonatal sepsis. J Matern Neonatal Med. 2019 Jan;32(1):143–53. | eng |
| dcterms.references | Tzialla C, Manzoni P, Achille C, Bollani L, Stronati M, Borghesi A. New Diagnostic Possibilities for Neonatal Sepsis. Am J Perinatol. 2018 May;35(06):575–7. | eng |
| dcterms.references | Sharma D, Farahbakhsh N, Shastri S, Sharma P. Biomarkers for diagnosis of neonatal sepsis: a literature review. J Matern Neonatal Med. 2018 Jun;31(12):1646–59. | eng |
| dcterms.references | Chauhan N, Tiwari S, Jain U. Potential biomarkers for effective screening of neonatal sepsis infections: An overview. Microb Pathog. 2017 Jun;107:234–42. | eng |
| dcterms.references | Rooney SP, Heffren JC, Song BL, Sanchez AC. Management of Sepsis in the Pediatric Patient. J Radiol Nurs. 2020 Mar;39(1):24–31. | eng |
| dcterms.references | Mukhopadhyay S, Wade KC, Puopolo KM. Drugs for the Prevention and Treatment of Sepsis in the Newborn. Clin Perinatol. 2019 Jun;46(2):327–47. | eng |
| dcterms.references | Molyneux E, Gest A. Neonatal sepsis: an old issue needing new answers. Lancet Infect Dis. 2015 May;15(5):503–5. | eng |
| dcterms.references | Arias D, Narváez C. Atención al recién nacido con hipertensión pulmonar persistente. Repert Med y Cirugía. 2016 Oct;25(4):219–27. | spa |
| dcterms.references | Limjoco J, Paquette L, Ramanathan R, Seri I, Friedlich P. Changes in Mean Arterial Blood Pressure During Sildenafil Use in Neonates With Meconium Aspiration Syndrome or Sepsis. Am J Ther. 2015;22(2):125–31. | eng |
| dcterms.references | Cabral JEB, Belik J. Persistent pulmonary hypertension of the newborn: recent advances in pathophysiology and treatment. J Pediatr (Rio J). 2013 May;89(3):226–42. | eng |
| dcterms.references | Montasser M, Patel N. Pulmonary hypertension in newborn infants: pathophysiology, clinical assessment and management. Paediatr Child Health (Oxford). 2021 Jan;31(1):32–7. | eng |
| dcterms.references | Prusakowski MK, Chen AP. Pediatric Sepsis. Emerg Med Clin North Am. 2017 Feb;35(1):123–38. | eng |
| dcterms.references | Calcaterra G, Bassareo PP, Barilla F, Martino F, Fanos V, Fedele F, et al. Pulmonary hypertension in pediatrics. A feasible approach to bridge the gap between real world and guidelines. J Matern Neonatal Med. 2019 Dec;0(0):1–7. | eng |
| dcterms.references | Sardar S, Pal S, Mishra R. A Retrospective study on the profile of persistent pulmonary hypertension of newborn in a tertiary care unit of Eastern India. J Clin Neonatol. 2020;9(1):18. | eng |
| dcterms.references | Tsai M-H, Hsu J-F, Chu S-M, Lien R, Huang H-R, Chiang M-C, et al. Incidence, Clinical Characteristics and Risk Factors for Adverse Outcome in Neonates With Late-onset Sepsis. Pediatr Infect Dis J. 2014 Jan;33(1):e7–13. | eng |
| dcterms.references | Tsai M-H, Wu IH, Lee C-W, Chu S-M, Lien R, Huang H-R, et al. Neonatal gram-negative bacillary late-onset sepsis: A case-control-control study on a prospectively collected database of 5,233 admissions. Am J Infect Control. 2016 Feb;44(2):146–53. | eng |
| dcterms.references | Jain A, McNamara PJ. Persistent pulmonary hypertension of the newborn: Advances in diagnosis and treatment. Semin Fetal Neonatal Med. 2015 Aug;20(4):262–71. | eng |
| dcterms.references | Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, et al. Updated Clinical Classification of Pulmonary Hypertension. J Am Coll Cardiol. 2013 Dec;62(25):D34–41. | eng |
| dcterms.references | Hopper RK, Abman SH, Ivy DD. Persistent Challenges in Pediatric Pulmonary Hypertension. Chest. 2016 Jul;150(1):226–36. | eng |
| dcterms.references | Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, et al. Pediatric Pulmonary Hypertension. Circulation. 2015 Nov;132(21):2037–99. | eng |
| dcterms.references | Fuloria M, Aschner JL. Persistent pulmonary hypertension of the newborn. Semin Fetal Neonatal Med. 2017 Aug;22(4):220–6. | eng |
| dcterms.references | Baker CD, Abman SH, Mourani PM. Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Pediatr Allergy Immunol Pulmonol. 2014 Mar;27(1):8–16. | eng |
| dcterms.references | Wardle AJ, Tulloh RMR. Paediatric pulmonary hypertension and sildenafil: current practice and controversies. Arch Dis Child - Educ Pract Ed. 2013 Aug;98(4):141–7. | eng |
| dcterms.references | Keller RL. Pulmonary Hypertension and Pulmonary Vasodilators. Clin Perinatol. 2016 Mar;43(1):187–202. | eng |
| dcterms.references | Lynch TD, Laffey JG. Hipertensión Pulmonar - Silfenafil - Revisión Cochrane. Anesthesiology. 2017;104(2):382; author reply 383. | eng |
| dcterms.references | Márquez-González H, Ibarra-Ríos D, Jean-Tron MG, Barajas-Nava LA. Uso de sildenafil para la hipertensión pulmonar en neonatos. Bol Med Hosp Infant Mex. 2020 Apr;77(4):202–6. | spa |
| dcterms.references | Ivy DD, Abman SH, Barst RJ, Berger RMF, Bonnet D, Fleming TR, et al. Pediatric Pulmonary Hypertension. J Am Coll Cardiol. 2013 Dec;62(25):D117–26. | eng |
| dcterms.references | Robbins IM, Moore TM, Blaisdell CJ, Abman SH. National Heart, Lung, and Blood Institute Workshop. Circulation. 2012 May;125(17):2165–70. | eng |
| dcterms.references | Li J, Chen S, Yan Y, Hu Y, Wei J, Wu Q, et al. Identification and antimicrobial resistance of pathogens in neonatal septicemia in China—A meta-analysis. Int J Infect Dis. 2018 Jun;71(2018):89–93. | eng |
| dcterms.references | Al-Matary A, Heena H, AlSarheed AS, Ouda W, AlShahrani DA, Wani TA, et al. Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia. J Infect Public Health. 2019 Sep;12(5):666–72. | eng |
| dcterms.references | Khan F. C-reactive Protein as a Screening Biomarker in Neonatal Sepsis. J Coll Physicians Surg Pakistan. 2019 Oct;29(10):951–3. | eng |
| dcterms.references | Seliem WA, Sultan AM. Etiology of early onset neonatal sepsis in neonatal intensive care unit – Mansoura, Egypt. J Neonatal Perinatal Med. 2018 Sep;11(3):323–30. | eng |
| dcterms.references | Hamer D, Mwananyanda L, Cowden C, Pierre C, Mwansa J, Lukwesa C, et al. Sepsis prevention in neonates in Zambia study: Impact of an infection prevention bundle on neonatal sepsis and mortality. Int J Infect Dis. 2018 Aug;73(2018):43. | eng |
| dcterms.references | Alcock G, Liley HG, Cooke L, Gray PH. Prevention of neonatal late-onset sepsis: a randomised controlled trial. BMC Pediatr. 2017 Dec;17(1):98. | eng |
| dcterms.references | Ruan L, Chen G-Y, Liu Z, Zhao Y, Xu G-Y, Li S-F, et al. The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review. Crit Care. 2018 Dec;22(1):316. | eng |
| dcterms.references | Burga-Montoya G, Luna Muñoz C, Correa López LE. Factores de riesgo asociados a sepsis neonatal temprana en prematuros de un Hospital Nacional Docente Madre Niño, 2017. Rev la Fac Med Humana. 2019 Jul;19(3):35–42. | spa |
| oaire.version | info:eu-repo/semantics/acceptedVersion | |
| sb.programa | Especialización en Pediatría | spa |
| sb.sede | Sede Barranquilla | spa |