Síndrome de Sjögren: identificación de nuevos biomarcadores y mecanismos moleculares implicados en su fisiopatogénesis
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.contributor.author | Vergara Serpa, Oscar Vicente | |
| dc.contributor.author | Ochoa Orlenis Sierra, Ochoa Orlenis Sierra | |
| dc.contributor.author | Espitia Muñoz, Vianh Carlos | |
| dc.contributor.author | Ordosgoitia Dickson, Luis Felipe | |
| dc.contributor.author | García, Juan Pablo | |
| dc.contributor.author | Diaz Suarez, Esteban David | |
| dc.contributor.author | Daza Arnedo, Rodrigo | |
| dc.contributor.author | Vázquez, Lourdes | |
| dc.contributor.author | Rico Fontalvo, Jorge | |
| dc.date.accessioned | 2024-07-03T22:51:56Z | |
| dc.date.available | 2024-07-03T22:51:56Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | El Síndrome de Sjögren (SS) es una enfermedad autoinmune de carácter sistémico, que afecta principalmente al sistema glandular exocrino, generando un funcionamiento anormal de las glándulas lacrimales y salivales. Objetivo: proporcionar una actualización sobre la identificación de nuevos biomarcadores y mecanismos moleculares implicados en la fisiopatogénesis del SS. Método: Revisión narrativa de la literatura en diferentes bases de datos, mediante la búsqueda de términos descritos incluidos en los tesauros MESH y DeCs, para artículos publicados a partir del año 2018. Resultados: presentamos evidencia que destaca la identificación de nuevos biomarcadores y mecanismos implicados en la fisiopatogénesis del SS, describiendo las vías de: linfocitos B, catepsina S, cistatina C, quimioquina C-X3-C modificada de ligando 1, quimiocina regulada por activación del timo, células T, proteína morfogenética ósea 6, estimulación del receptor de oxitocina, receptor de zinc, calponina-3. Conclusión: los avances en la tecnología facilita el análisis detallado de la genética y fisiopatogénesis del SS, impulsando el desarrollo de terapias específicas. La búsqueda de biomarcadores no invasivos responde a las limitaciones de los métodos existentes y la invasividad de las biopsias salivales, prometiendo mejoras diagnósticas y terapéuticas. | spa |
| dc.description.abstract | Sjögren's Syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glandular system, leading to abnormal lacrimal and salivary gland function. Objective: To provide an update on identifying new biomarkers and molecular mechanisms involved in the pathogenesis of SS. Method: Narrative review of the literature in various databases, searching for terms included in the MESH and DeCs thesauri, for articles published since 2018. Results: We present evidence highlighting the identification of new biomarkers and mechanisms involved in the pathogenesis of SS, describing pathways of B lymphocytes, cathepsin S, cystatin C, modified C-X3-C chemokine ligand 1, thymus activation-regulated chemokine, T cells, bone morphogenetic protein 6, oxytocin receptor stimulation, zinc receptor, and calponin-3. Conclusion: Advances in technology facilitate detailed analysis of the genetics and pathogenesis of SS, driving the development of specific therapies. The search for non-invasive biomarkers is driven by the limitations of existing methods and the invasiveness of salivary gland biopsies, promising diagnostic and therapeutic improvements. | eng |
| dc.format.mimetype | ||
| dc.identifier.doi | https://doi.org/10.18004/rpr/2024.10.01.22 | |
| dc.identifier.issn | 24134341 (En línea) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/14802 | |
| dc.identifier.url | http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S2413-43412024000100022&lng=es&nrm=iso&tlng=es | |
| dc.language.iso | spa | |
| dc.publisher | Sociedad Paraguaya de Reumatología | spa |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
| dc.source | Revista Paraguaya de Reumatología | spa |
| dc.source | Rev. parag. reumatol. | spa |
| dc.source | Vol. 10 No. 1, (2024) | |
| dc.subject | Síndrome de Sjögren | spa |
| dc.subject | Xerostomía | spa |
| dc.subject | Biomarcadores | spa |
| dc.subject | Fisiopatología | spa |
| dc.subject | Genética | spa |
| dc.subject | Linfocitos B | spa |
| dc.subject | Autoanticuerpos | spa |
| dc.subject | Autoinmunidad | spa |
| dc.subject.keywords | Sjögren’s syndrome | eng |
| dc.subject.keywords | Xerostomia | eng |
| dc.subject.keywords | Biomarkers | eng |
| dc.subject.keywords | Physiopathology | eng |
| dc.subject.keywords | Genetic | eng |
| dc.subject.keywords | B-Lymphocytes | eng |
| dc.subject.keywords | Autoantibodies | eng |
| dc.subject.keywords | Autoimmunity | eng |
| dc.title | Síndrome de Sjögren: identificación de nuevos biomarcadores y mecanismos moleculares implicados en su fisiopatogénesis | spa |
| dc.title.translated | Sjögren‘s syndrome: identification of new biomarkers and molecular mechanisms involved in its pathophysiology | eng |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.spa | Artículo científico | |
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| oaire.version | info:eu-repo/semantics/publishedVersion |