Prospective evaluation of lipid management following acute coronary syndrome in non-Western countries
Cargando...
Archivos
Fecha
2021
Autores
Navar, Ann Marie
Matskeplishvili, Simon T.
Urina-Triana, Miguel
Arafah, Mohammed
Chen, Jaw-Wen
Sukonthasarn, Apichard
Corp dit Genti, Valérie
Daclin, Véronique
Peterson, Eric D.
Título de la revista
ISSN de la revista
Título del volumen
Editor
Wiley
Resumen
Background: Half the global burden of cardiovascular disease (CVD) is concentrated
in the Asia-Pacific (APAC) region.
Hypothesis: Suboptimal control of low-density lipoprotein cholesterol (LDL-C) may
play a large role in the burden of CVD in APAC and non-Western countries.
Methods: The Acute Coronary Syndrome Management (ACOSYM) registry is a multinational,
multicenter, prospective observational registry designed to evaluate LDL-C
control in patients within 6 months after hospitalization following an acute coronary
syndrome (ACS) event across nine countries.
Results: Overall, 1581 patients were enrolled, of whom 1567 patients met the eligibility
criteria; 80.3% of the eligible patients were men, 46.1% had ST-elevation myocardial
infarction, and 39.5% had non-ST-elevation myocardial infarction. Most
(1245; 79.5%) patients were discharged on a high-intensity statin. During the followup,
only 992 (63.3%) patients had at least one LDL-C measurement; of these, 52.9%
had persistently elevated LDL-C (>70 mg/dl). The patients not discharged on a highdose
statin were more likely (OR 3.2; 95% CI 2.1–4.8) to have an LDL-C above the
70 mg/dl LDL-C target compared with those who were discharged on a high-dose
statin.
Conclusion: Our real-world registry found that a third or more of post-ACS patients
did not have a repeat LDL-C follow-up measurement. In those with an LDL-C followup
measurement, more than half (52.9%) were not achieving a <70 mg/dl LDL-C goal,
despite a greater uptake of high-intensity statin therapy than has been observed in
recent evidence. This demonstrates the opportunity to improve post-ACS lipid management
in global community practice.
Descripción
Palabras clave
Acute coronary syndrome, Iipid management, Low-density lipoprotein cholesterol, Non- Western countries, Statin therapy
