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Análisis clínico-epidemiológico de las subfracciones HDL2 y HDL3 en adultos de la ciudad de Maracaibo, Venezuela

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorLinares, Sergia
dc.contributor.authorBermúdez, Valmore
dc.contributor.authorSalazar, Juan
dc.contributor.authorNava, Manuel
dc.contributor.authorOrtega, Ángel
dc.contributor.authorOlivar, Luis
dc.contributor.authorCalvo, María
dc.contributor.authorMartínez, María Sofía
dc.contributor.authorMorales-Carrasco, Alex
dc.contributor.authorChacín, Maricarmen
dc.contributor.authorRojas, Joselyn
dc.date.accessioned2020-12-18T19:53:57Z
dc.date.available2020-12-18T19:53:57Z
dc.date.issued2020
dc.description.abstractObjetivo: Realizar un análisis clínico-epidemiológico de las subfracciones de colesterol unido a lipoproteinas de alta densidad (HDL-C, por sus siglas en inglés) en adultos de la ciudad de Maracaibo, Venezuela. Materiales y métodos: Se realizó un estudio descriptivo y transversal de la base de datos del Estudio de Prevalencia de Síndrome Metabólico de Maracaibo, que incluyó 359 individuos de ambos sexos, mayores de 18 años, a quienes se les determinó la concentración sérica de HDL3 y HDL2, así como el índice HDL2/ HDL3; evaluando sus niveles según características sociodemográficas, clínicas y bioquímicas. Resultados: La edad promedio de la población era 39,4 ± 15,2 años, y 51,5% era de sexo femenino. Solo se observaron diferencias en los niveles de HDL-C en aquellos sujetos con HDL-C bajas. Las mujeres con hipertriacilgliceridemia mostraron concentraciones séricas de HDL3 y HDL2 significativamente menores con respecto a aquellas con triacilglicéridos normales (p = 0,033); asimismo, se encontró una concentración menor de HDL3 y relación HDL2/HDL3 en aquellas con proteína C reactiva ultrasensible (PCR-us) elevada (p < 0,001). En hombres, se evidenció una concentración significativamente menor de HDL2 en aquellos con algún grado de hipertensión arterial (p = 0,031), insulinorresistencia (p = 0,050) y síndrome metabólico (p = 0,003); mientras que aquellos con PCR-us elevada mostraron una menor concentración de HDL3 (p = 0,011). Conclusión: Las subfracciones de HDL-C muestran un comportamiento clínico epidemiológico variable en adultos de la población de Maracaibo, con promedios más bajos en los hombres, diferencias en los niveles únicamente en aquellos con HDL-C bajas, y sin predominio de alguna subclase según las características sociodemográficas, clínicas y bioquímicas.spa
dc.description.abstractObjective: To carry out a clinical-epidemiological analysis of high-density lipoprotein cholesterol subfractions (HDL-C) in adults from Maracaibo, Venezuela. Materials and methods: A descriptive and cross-sectional study of the database from the Metbolic Syndrome Prevalence in Maracaibo Study was carried out. HDL3 and HDL2 serum concentration, as well as the HDL2/HDL3 ratio, were determined in 359 individuals of both sexes, over 18 years of age. Values obtained were evaluated according to sociodemographic, clinical and biochemical characteristics. Results: Mean population age was 39.4 ± 15.2 years, and 51.5% were female. Di fferences in HDL-C subfraction levels were only observed in those subjects with low HDL-C levels. Women with hypertriglyceridemia showed significantly lower serum HDL3 and HDL2 concentrations than those with normal triglycerides (p=0.033), as well as a lower HDL3 level and HDL2 / HDL3 ratio in those with higher levels of ultra-sensitive C-reactive protein (us-CRP) (p<0.001). A significantly lower concentration of HDL2 was observed in men with some degree of hypertension (p=0.031), insulin resistance (p=0.050) and metabolic syndrome (p=0.003); while those with elevated us-CRP showed a lower concentration of HDL3 (p=0.011). Conclusion: HDL-C subfractions show varying clinical-epidemiological behavior in adults from Maracaibo. Lower serum levels are observed in men, differences only in those with low HDL-C; and no predominance of any subclass was observed according to sociodemographic, clinical and biochemical characteristicseng
dc.format.mimetypepdfspa
dc.identifier.doihttps://doi.org/10.17843/ rpmesp.2020.373.4787.
dc.identifier.issn17264642
dc.identifier.urihttps://hdl.handle.net/20.500.12442/6940
dc.identifier.urlhttps://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4787
dc.language.isospaspa
dc.publisherInstituto Nacional de Salud. Lima, Perúspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceRevista Peruana de Medicina Experimental y Salud Públicaspa
dc.sourceVol. 37, No. 3 (2020)
dc.subjectLipoproteínas HDL3spa
dc.subjectLipoproteínas HDL2spa
dc.subjectHDL-Colesterolspa
dc.subjectFactores de riesgospa
dc.subjectEpidemiologíaspa
dc.subjectLipoproteins, HDL3eng
dc.subjectLipoproteins, HDL2eng
dc.subjectCholesterol, HDLeng
dc.subjectRisk Factorseng
dc.subjectEpidemiologyeng
dc.titleAnálisis clínico-epidemiológico de las subfracciones HDL2 y HDL3 en adultos de la ciudad de Maracaibo, Venezuelaspa
dc.title.translatedClinical-Epidemiological Analysis of HDL2 and HDL3 subfractions in Adults from Maracaibo City, Venezuelaeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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