Factor de necrosis tumoral como marcador inflamatorio en pacientes con enfermedad pulmonar obstructiva crónica
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Fecha
2017
Autores
Silva Paredes, Carlos
Bello, Luis Miguel
Bermúdez, Valmore
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Editor
Sociedad Venezolana de Farmacología Clínica y Terapéutica
Resumen
La EPOC es una enfermedad inflamatoria crónica que afecta
principalmente a los bronquios menores de 2 mm de diámetro.
Esta inflamación es un mecanismo activo y progresivo
con picos de aumento durante las exacerbaciones, y su desactivación
se dificulta a medida que la enfermedad progresa
y se establece el daño estructural. La respuesta inflamatoria
se caracteriza por un incremento de los valores de mediadores
inflamatorios circulantes en sangre como la PCR (Proteína
C Reactiva), fibrinógeno, leucocitos, FNT (Factor de
Necrosis Tumoral) e Interleukinas 6 y 8. El factor de necrosis
tumoral (TNF) es un regulador proinflamatorio central del sistema
inmune, y son producidos principalmente por macrófagos
activados. El TNFα desempeña un papel importante en
muchas enfermedades inflamatorias del pulmón, siendo las
más importantes la enfermedad pulmonar obstructiva crónica
(EPOC), el asma, la lesión pulmonar aguda y el síndrome de
dificultad respiratoria aguda severa (SDRA).
COPD is a chronic inflammatory disease that mainly affects bronchi less than 2 mm in diameter. This inflammation is an active and progressive mechanism with peaks of increase during exacerbations, and its deactivation becomes difficult as the disease progresses and structural damage is established. The inflammatory response is characterized by an increase in blood circulating inflammatory mediators such as CRP, fibrinogen, leukocytes, TNF (Tumor Necrosis Factor), and Interleukins 6 and 8. Tumor necrosis factor (TNF) is a central proinflammatory regulator of the immune system, and is produced primarily by activated macrophages. TNFα plays an important role in many inflammatory lung diseases, the most important of which are chronic obstructive pulmonary disease (COPD), asthma, acute lung injury and severe acute respiratory distress syndrome (ARDS).
COPD is a chronic inflammatory disease that mainly affects bronchi less than 2 mm in diameter. This inflammation is an active and progressive mechanism with peaks of increase during exacerbations, and its deactivation becomes difficult as the disease progresses and structural damage is established. The inflammatory response is characterized by an increase in blood circulating inflammatory mediators such as CRP, fibrinogen, leukocytes, TNF (Tumor Necrosis Factor), and Interleukins 6 and 8. Tumor necrosis factor (TNF) is a central proinflammatory regulator of the immune system, and is produced primarily by activated macrophages. TNFα plays an important role in many inflammatory lung diseases, the most important of which are chronic obstructive pulmonary disease (COPD), asthma, acute lung injury and severe acute respiratory distress syndrome (ARDS).
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Palabras clave
Enfermedad pulmonar obstructiva crónica, Factor de necrosis tumoral, Inflamación, Cigarrillo, Mediadores inflamatorios, Chronic obstructive pulmonary disease, Tumor necrosis factor, Inflammation, Cigarette, Inflammatory mediators