Prediabetes and CKD: does a causal relationship exist?
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Fecha
2024
Autores
Rico Fontalvo, Jorge
Soler, María José
Daza Arnedo, Rodrigo
Navarro-Blackaller, Guillermo
Medina-González, Ramón
Rodríguez Yánez, Tomas
Cardona-Blanco, Maria
Cabrales-Juan, Jose
Uparrela-Gulfo, Isabella
Chávez-Iñiguez, Jonathan S.
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Sociedad Española de Nefrología
Resumen
The relationship between diabetes and the development of kidney complications is
well known, but the understanding of prediabetes and insulin resistance with
impaired kidney function has been scarcely assessed. Various factors could explain
this phenomenon, from the lack of standardization in the definitions of prediabetes,
to the erratic and inconsistent evidence in large-scale epidemiological and cohort
studies. It seems that the pathophysiological pathway of prediabetes could be
related to inflammation and neurohormonal hyperactivation, factors present even
before the onset of diabetes, which might be the main drivers of glomerular hyperfiltration, albuminuria, and impaired glomerular filtration rate. It is possible that
existing treatments for the management of diabetes, as metformin or SGLT2
inhibitors may also be useful in patients with prediabetes with evidence of functional
and structural kidney damage. The purpose of this review is to summarize the
evidence regarding the relationship between prediabetes(preDM) and the
development of CKD.
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Fontalvo JR, Soler MJ, Arnedo RD, Navarro-Blackaller G, Medina-González R, Yánez TR, Cardona-Blanco M, Cabrales-Juan J, Uparrela-Gulfo I, Chávez-Iñiguez JS, Prediabetes and CKD: does a causal relationship exist? (2024), doi: https://doi.org/10.1016/j.nefro.2024.06.008
