Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
| dc.contributor.author | Angarita Dávila, Lisse | spa |
| dc.contributor.author | Bermúdez, Valmore | spa |
| dc.contributor.author | Aparicio, Daniel | spa |
| dc.contributor.author | Céspedes, Virginia | spa |
| dc.contributor.author | Escobar, Ma. Cristina | spa |
| dc.contributor.author | Durán-Agüero, Samuel | spa |
| dc.contributor.author | Cisternas, Silvana | spa |
| dc.contributor.author | Costa, Jorge de Assis | spa |
| dc.contributor.author | Rojas-Gómez, Diana | spa |
| dc.contributor.author | Reyna, Nadia | spa |
| dc.contributor.author | López-Miranda, Jose | spa |
| dc.date.accessioned | 2019-07-19T19:03:14Z | |
| dc.date.available | 2019-07-19T19:03:14Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors. | eng |
| dc.identifier.issn | 20726643 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/3598 | |
| dc.language.iso | eng | eng |
| dc.publisher | MDPI | eng |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Nutrients | eng |
| dc.source | Vol. 11, Núm. 7, 2019 | eng |
| dc.source.uri | https://doi.org/10.3390/nu11071477 | |
| dc.subject | Glycaemic index | eng |
| dc.subject | Incretins | eng |
| dc.subject | Subjective appetite | eng |
| dc.subject | Isomaltulose | eng |
| dc.subject | Sucromalt | eng |
| dc.subject | Nutritional supplement | eng |
| dc.title | Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study | eng |
| dc.type | article | eng |
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