Logotipo del repositorio
Logotipo del repositorio
 

Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study

Vista sencilla de ítem
datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
dc.contributor.authorGaravito De Egea, Gloria
dc.contributor.authorDomínguez‑Vargas, Alex
dc.contributor.authorFang, Luis
dc.contributor.authorPereira‑Sanandrés, Nicole
dc.contributor.authorRodríguez, Jonathan
dc.contributor.authorAroca‑Martinez, Gustavo
dc.contributor.authorEspítatela, Zilac
dc.contributor.authorMalagón, Clara
dc.contributor.authorIglesias‑Gamarra, Antonio
dc.contributor.authorMoreno‑Woo, Ana
dc.contributor.authorLópez‑Lluch, Guillermo
dc.contributor.authorEgea, Eduardo
dc.date.accessioned2024-03-15T20:31:19Z
dc.date.available2024-03-15T20:31:19Z
dc.date.issued2024
dc.description.abstractBackground Adiponectin and leptin are pivotal in the regulation of metabolism. Pediatric lupus nephritis (pLN), a manifestation of childhood systemic lupus erythematosus (SLE) affecting the kidneys, is associated with impaired adipokine levels, suggesting a role in pLN pathogenesis. The aim of this study was to explore the potential relationship between specific single-nucleotide polymorphisms (SNPs)—methylenetetrahydrofolate reductase (MTHFR) rs1801131 and fibrinogen gamma chain (FGG) rs2066865—and the serum levels of leptin and adiponectin in patients with pLN. Methods Ninety-eight pLN patients and one hundred controls were enrolled in the study. Serum leptin and adiponectin levels were measured using ELISA. DNA extraction and real-time PCR genotyping were performed for MTHFR rs1801131 and FGG rs2066865 SNPs. Results Compared to healthy controls, pLN patients exhibited significantly greater serum leptin (11.3 vs. 18.2 ng/ mL, p < 0.001) and adiponectin (18.2 vs. 2.7 ug/mL, p < 0.001). Adiponectin levels were positively correlated with proteinuria (p < 0.05), while leptin levels positively correlated with proteinuria, SLE disease activity index-2000 (SLEDAI-2K), and cyclophosphamide usage (all p < 0.05). There was no significant association between MTHFR rs1801131 or FGG rs2066865 SNPs and pLN in either codominant or allelic models (all p > 0.05). However, the AG genotype of FGG gene rs2066865 SNP was significantly associated with high leptin levels (> 15 ng/mL) (p = 0.01). Conclusion Serum adiponectin and leptin levels are associated with pathological manifestations of pLN. High leptin levels are associated with the AG genotype of FGG rs2066865 SNP in pLN patients, suggesting direct involvement in disease progression and potential utility as a disease biomarker.eng
dc.format.mimetypepdfspa
dc.identifier.citationDe Egea, G.G., Domínguez-Vargas, A., Fang, L. et al. Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study. Egypt J Med Hum Genet 25, 34 (2024). https://doi.org/10.1186/s43042-024-00507-4eng
dc.identifier.doihttps://doi.org/10.1186/s43042-024-00507-4
dc.identifier.issn20902441 (electrónico)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/14374
dc.identifier.urlhttps://jmhg.springeropen.com/articles/10.1186/s43042-024-00507-4
dc.language.isoengeng
dc.publisherSpringer Natureeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceEgyptian Journal of Medical Human Geneticseng
dc.sourceVol. 25 N° 34, (2024)
dc.subjectPediatric lupus nephritiseng
dc.subjectAdiponectineng
dc.subjectLeptineng
dc.subjectMTHFReng
dc.subjectFGGeng
dc.subjectPolymorphismeng
dc.titleExploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot studyeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
dcterms.referencesMoulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC (2017) Pathogenesis of human systemic lupus erythematosus: a cellular perspective. Trends Mol Med 23(7):615–635. https://doi.org/10.1016/j.molmed.2017.05.006eng
dcterms.referencesPinto Peñaranda LF, Castro Mercado IL, Duque Caballero V, Márquez Hernández JD, Velásquez Franco CJ (2014) Factores de riesgo predictores de falla a la terapia de inducción de nefritis lúpica en una cohorte de pacientes colombianos. Reumatol Clínica 10(3):147–151. https://doi.org/10.1016/j.reuma.2013.09.005spa
dcterms.referencesValdivielso JM, Rodríguez-Puyol D, Pascual J et al (2019) Atherosclerosis in chronic kidney disease. Arterioscler Thromb Vasc Biol 39(10):1938–1966. https://doi.org/10.1161/ATVBAHA.119.312705eng
dcterms.referencesSelzer F, Sutton-Tyrrell K, Fitzgerald SG et al (2004) Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus. Arthritis Rheum 50(1):151–159. https://doi.org/10.1002/art.11418eng
dcterms.referencesBruce IN, Urowitz MB, Gladman DD, Ibañez D, Steiner G (2003) Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto risk factor study. Arthritis Rheum 48(11):3159–3167. https://doi.org/10.1002/art.11296eng
dcterms.referencesDoria A (2003) Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus. Ann Rheum Dis 62(11):1071–1077. https://doi.org/10.1136/ard.62.11.1071eng
dcterms.referencesSozeri B, Deveci M, Dincel N, Mir S (2013) The early cardiovascular changes in pediatric patients with systemic lupus erythematosus. Pediatr Nephrol 28(3):471–476. https://doi.org/10.1007/s00467-012-2342-2eng
dcterms.referencesde Souza Barbosa V, Francescantônio PL, da Silva NA (2015) Leptin and adiponectin in patients with systemic lupus erythematosus: clinical and laboratory correlations. Rev Bras Reumatol (Engl Ed) 55(2):140–145. https://doi.org/10.1016/j.rbre.2014.08.013eng
dcterms.referencesZhang TP, Li HM, Leng RX et al (2016) Plasma levels of adipokines in systemic lupus erythematosus patients. Cytokine 86:15–20. https://doi.org/10.1016/j.cyto.2016.07.008eng
dcterms.referencesGiannelou M, Nezos A, Fragkioudaki S et al (2018) Contribution of MTHFR gene variants in lupus related subclinical atherosclerosis. Clin Immunol 193:110–117. https://doi.org/10.1016/j.clim.2018.02.014eng
dcterms.referencesLi HM, Zhang TP, Leng RX et al (2016) Emerging role of adipokines in systemic lupus erythematosus. Immunol Res 64(4):820–830. https://doi.org/10.1007/s12026-016-8808-8eng
dcterms.referencesPetri M, Roubenoff R, Dallal GE, Nadeau MR, Selhub J, Rosenberg IH (1996) Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet 348(9035):1120–1124. https://doi.org/10.1016/S0140-6736(96)03032-2eng
dcterms.referencesSantilli F, Davì G, Patrono C (2016) Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: a mechanistic and clinical perspective. Vascul Pharmacol 78:1–9. https://doi.org/10.1016/j.vph.2015.06.009eng
dcterms.referencesZhou HY, Yuan M (2020) MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: a meta-analysis. Medicine 99(40):E22614. https://doi.org/10.1097/MD.0000000000022614eng
dcterms.referencesDias S, Adam S, Rheeder P, Pheiffer C (2021) No association between ADIPOQ or MTHFR polymorphisms and gestational diabetes mellitus in South African women. Diabetes Metab Syndr Obes 14:791–800. https://doi.org/10.2147/DMSO.S294328eng
dcterms.referencesLuo Z, Lu Z, Muhammad I et al (2018) Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis. Lipids Health Dis 17(1):191. https://doi.org/10.1186/s12944-018-0837-yeng
dcterms.referencesKaiser R, Li Y, Chang M et al (2012) Genetic risk factors for thrombosis in systemic lupus erythematosus. J Rheumatol 39(8):1603–1610. https://doi.org/10.3899/jrheum.111451eng
dcterms.referencesUitte De Willige S, Rietveld IM, Visser Mch De, Vos HL, Bertina RM (2007) Polymorphism 10034C>T is located in a region regulating polyadenylation of FGG transcripts and influences the fibrinogen γ′/γA mRNA ratio. J Thromb Haemost 5(6):1243–1249. https://doi.org/10.1111/j.1538-7836.2007.02566.xeng
dcterms.referencesDrizlionoka K, Zariņš J, Ozoliņa A, Ņikitina-Zaķe L, Mamaja B (2019) Polymorphism rs2066865 in the fibrinogen gamma chain (FGG) gene increases plasma fibrinogen concentration and is associated with an increased microvascular thrombosis rate. Medicina. https://doi.org/10.3390/medicina55090563eng
dcterms.referencesOzgokce C, Elci E, Yildizhan R (2020) C-reactive protein, fibrinogen, leptin, and adiponectin levels in women with polycystic ovary syndrome. J Obstet Gynecol India 70(6):490–496. https://doi.org/10.1007/s13224-020-01331-7eng
dcterms.referencesHahn BH, McMahon MA, Wilkinson A et al (2012) American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res 64(6):797–808. https://doi.org/10.1002/acr.21664eng
dcterms.referencesRuiz Irastorza G, Espinosa G, Frutos MA et al (2012) Diagnosis and treatment of lupus nephritis consensus document from the systemic auto-immune disease group (GEAS) of the Spanish Society of Internal Medicine (SEMI) and Spanish Society of Nephrology (SEN). Nefrologia 32(Suppl 1):1–35. https://doi.org/10.3265/Nefrologia.pre2011.Dec.11298eng
dcterms.referencesSimón E, Del Barrio AS (2002) Leptina y obesidad. An Sist Sanit Navar 25(SUPPL. 1):53–64eng
dcterms.referencesChandran M, Phillips SA, Ciaraldi T, Henry RR (2003) Adiponectin: More than just another fat cell hormone? Diabetes Care 26(8):2442–2450. https://doi.org/10.2337/diacare.26.8.2442eng
dcterms.referencesAbella V, Scotece M, Conde J et al (2017) Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol 13(2):100–109. https://doi.org/10.1038/nrrheum.2016.209eng
dcterms.referencesAlmaani S, Meara A, Rovin BH (2017) Update on lupus nephritis. Clin J Am Soc Nephrol 12(5):825–835. https://doi.org/10.2215/CJN.05780616eng
dcterms.referencesSchwartzman-Morris J, Putterman C (2012) Gender differences in the pathogenesis and outcome of lupus and of lupus nephritis. Clin Dev Immunol 2012:604892. https://doi.org/10.1155/2012/604892eng
dcterms.referencesSmekal A, Vaclavik J (2017) Adipokines and cardiovascular disease: a comprehensive review. Biomed Pap 161(1):31–40. https://doi.org/10.5507/bp.2017.002eng
dcterms.referencesFreitas Lima LC, Braga VDA, do Socorro de França Silva M et al (2015) Adipokines, diabetes and atherosclerosis: an inflammatory association. Front Physiol. https://doi.org/10.3389/fphys.2015.00304eng
dcterms.referencesAbulaban KM, Brunner HI (2015) Biomarkers for childhood-onset systemic lupus erythematosus. Curr Rheumatol Rep 17(1):471. https://doi.org/10.1007/s11926-014-0471-2eng
dcterms.referencesBarbosa VD, Francescantônio PL, Silva NA (2015) Leptina e adiponectina no lúpus eritematoso sistêmico: correlações clínicas e laboratoriais. Rev Bras Reumatol 55(2):140–145. https://doi.org/10.1016/j.rbr.2014.08.014eng
dcterms.referencesFantuzzi G (2008) Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol 121(2):326–330. https://doi.org/10.1016/j.jaci.2007.10.018eng
dcterms.referencesSada KE, Yamasaki Y, Maruyama M et al (2006) Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus. J Rheumatol 33(8):1545–1552eng
dcterms.referencesToussirot É, Gaugler B, Bouhaddi M, Nguyen NU, Saas P, Dumoulin G (2010) Elevated adiponectin serum levels in women with systemic autoimmune diseases. Mediat Inflamm 2010:1–6. https://doi.org/10.1155/2010/938408eng
dcterms.referencesHutcheson J, Ye Y, Han J et al (2015) Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol 179(3):435–443. https://doi.org/10.1111/cei.12473eng
dcterms.referencesFujita H, Morii T, Koshimura J et al (2006) Possible relationship between adiponectin and renal tubular injury in diabetic nephropathy. Endocr J 53(6):745–752. https://doi.org/10.1507/endocrj.K06-016eng
dcterms.referencesTsioufis C, Dimitriadis K, Chatzis D et al (2005) Relation of microalbuminuria to adiponectin and augmented C-reactive protein levels in men with essential hypertension. Am J Cardiol 96(7):946–951. https://doi.org/10.1016/j.amjcard.2005.05.052eng
dcterms.referencesRovin BH, Song H, Hebert LA et al (2005) Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 68(4):1825–1833. https://doi.org/10.1111/j.1523-1755.2005.00601.xeng
dcterms.referencesKamel SM, Abdel Azeem ME, Mohamed RA, Kamel MM, Abdel Aleem EA (2023) High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus. Int J Immunopathol Pharmacol 37:3946320231154988. https://doi.org/10.1177/03946320231154988eng
dcterms.referencesReagan M, Salim NA, Junaidi, Hermansyah (2019) Comparison of leptin serum levels between systemic lupus erythematosus (SLE) and non-SLE patients at Mohammad Hoesin Hospital Palembang. J Phys Conf Ser 1246(1):012046. https://doi.org/10.1088/1742-6596/1246/1/012046eng
dcterms.referencesWisłowska M, Rok M, Stępień K, Kuklo-Kowalska A (2008) Serum leptin in systemic lupus erythematosus. Rheumatol Int 28(5):467–473. https://doi.org/10.1007/s00296-008-0526-7eng
dcterms.referencesLee YH, Song GG (2018) Association between circulating leptin levels and systemic lupus erythematosus: an updated meta-analysis. Lupus 27(3):428–435. https://doi.org/10.1177/0961203317725587eng
dcterms.referencesMcMahon M, Skaggs BJ, Sahakian L et al (2011) High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis 70(9):1619–1624. https://doi.org/10.1136/ard.2010.142737eng
dcterms.referencesVadacca M, Zardi EM, Margiotta D et al (2013) Leptin, adiponectin and vascular stiffness parameters in women with systemic lupus erythematosus. Intern Emerg Med 8(8):705–712. https://doi.org/10.1007/s11739-011-0726-0eng
dcterms.referencesTam LS, Fan B, Li EK et al (2003) Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia. J Rheumatol 30(7):1479–1484eng
dcterms.referencesSalimi S, Keshavarzi F, Mohammadpour-Gharehbagh A et al (2017) Polymorphisms of the folate metabolizing enzymes: association with SLE susceptibility and in silico analysis. Gene 637:161–172. https://doi.org/10.1016/j.gene.2017.09.037eng
dcterms.referencesOssa H, Aquino J, Pereira R et al (2016) Outlining the ancestry landscape of colombian admixed populations. PLoS ONE 11(10):e0164414. https://doi.org/10.1371/journal.pone.0164414eng
dcterms.referencesVon Feldt JM, Scalzi LV, Cucchiara AJ et al (2006) Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus. Arthritis Rheum 54(7):2220–2227. https://doi.org/10.1002/art.21967eng
dcterms.referencesRua-Figueroa I, Arencibia-Mireles O, Elvira M et al (2010) Factors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: a 2-year longitudinal study. Ann Rheum Dis 69(6):1136–1139. https://doi.org/10.1136/ard.2008.104349eng
oaire.versioninfo:eu-repo/semantics/publishedVersionspa

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
PDF.pdf
Tamaño:
1.02 MB
Formato:
Adobe Portable Document Format
Descripción:
PDF
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
381 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos

Universidad Simón Bolívar: Todos los derechos reservados / Sistema de biblioteca