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From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID

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datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
dc.contributor.authorGonzalez-Garcia, Pablo
dc.contributor.authorFiorillo Moreno, Ornella
dc.contributor.authorPacheco Lugo, Lisandro
dc.contributor.authorAcosta Hoyos, Antonio
dc.contributor.authorVillarreal Camacho, José Luis
dc.contributor.authorNavarro Quiroz, Roberto
dc.contributor.authorPacheco Londoño, Leonardo
dc.contributor.authorAroca Martínez, Gustavo
dc.contributor.authorMoares, Noelia
dc.contributor.authorGabucio, Antonio
dc.contributor.authorFernández-Ponce, Cecilia
dc.contributor.authorGarcia-Cozar, Francisco
dc.contributor.authorNavarro Quiroz, Elkin
dc.date.accessioned2023-04-27T22:07:52Z
dc.date.available2023-04-27T22:07:52Z
dc.date.issued2023
dc.description.abstractSevere Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers var-ious events from the molecular to the tissue level, which in turn is given by the intrinsic character-istics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cytopathic, tissue, and clinical effects are difficult to predict, which determines the hetero-geneity of COVID-19 symptoms. The purpose of this article is to provide a comprehensive review of the cytopathic effects of SARS-CoV-2 on various cell types, focusing on the development of COVID-19, which in turn may lead, in some patients, to the persistence of symptoms after recovery from the disease, a condition known as long COVID. We describe the molecular mechanisms un-derlying virus–host interactions, including alterations in protein expression, intracellular signaling pathways, and immune responses. In particular, the article highlights the potential impact of these cytopathies on cellular function and clinical outcomes, such as immune dysregulation, neuropsy-chiatric disorders, and organ damage. The article concludes by discussing future directions for re-search and implications for the management and treatment of COVID-19 and long COVID.eng
dc.format.mimetypepdfspa
dc.identifier.citationGonzalez-Garcia, P.; Fiorillo Moreno, O.; Peñate, E.Z.; Calderon-Villalba, A.; Pacheco Lugo, L.; Hoyos, A.A.; Camacho, J.L.V.; Quiroz, R.N.; Londoño, L.P.; Aroca Martinez, G.; et al. From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID. Int. J. Mol. Sci. 2023, 24, x. https://doi.org/10.3390/xxxxxspa
dc.identifier.doihttp://dx.doi.org/10.3390/xxxxx
dc.identifier.issn14220067
dc.identifier.urihttps://hdl.handle.net/20.500.12442/12310
dc.identifier.urlhttps://www.mdpi.com/journal/ijms
dc.language.isoengeng
dc.publisherMDPIspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceInternational Journal of Molecular Scienceseng
dc.sourceint. J. Mol. Sci.eng
dc.sourceVol 24, No X, (2023)
dc.subjectCOVID-19spa
dc.subjectSARS-CoV-2eng
dc.subjectLong COVIDeng
dc.subjectCytopathyeng
dc.subjectCytokine stormeng
dc.subjectSequelaeeng
dc.subjectPASCeng
dc.subjectCoronaviruseng
dc.subjectAngiotensin-converting enzyme 2eng
dc.subjectCell dysfunctioneng
dc.titleFrom Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVIDeng
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.spaArtículo científicospa
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