WCN26-436 De novo idiopathic nodular glomerulosclerosis in a kidney transplant patient

Dulce, Jaime A.; Cabarcas, Omar; Niño, Lucia; Aroca-Martinez, Gustavo

WCN26-436 De novo idiopathic nodular glomerulosclerosis in a kidney transplant patient

Archivos

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Fecha

2026

Autores

Dulce, Jaime A.

Cabarcas, Omar

Niño, Lucia

Aroca-Martinez, Gustavo

Editor

International Society of Nephrology ISN

Resumen

Chronic Kidney Disease is a condition characterized by a progressive and irreversible decrease in kidney function that can be caused by different etiologies, among which are primary or secondary glomerular diseases (1). Within renal replacement therapies; Transplantation is the modality that provides the greatest benefit in terms of quality of life and mortality. Renal graft survival can be affected not only by rejection and infections but also by relapse in the graft of a glomerular disease that affected the native kidney or otherwise, a de novo onset (2)(3). A study of 1505 transplant patients between 1988- 1997 with a diagnosis of confirmed glomerular disease documented that recurrence was the third most common cause of allograft loss at 10 years, after chronic rejection and death with a functioning allograft (4). It should be noted that live transplantation has better HLA compatibility and therefore greater graft survival, however increased rates of primary glomerulonephritis recurrence have been noted in this group of patients (5). Nodular glomerulonephritis is a histological lesion pattern characterized by the presence of hyaline deposits in the mesangial matrix with a nodule-like distribution; It also shows glomerular vascular involvement, and its usual clinical manifestation may be complete nephrotic syndrome or significant proteinuria. This type of injury is closely related mainly in patients with Diabetes Mellitus and smokers with a high rate of smoking activity. The de novo appearance of this type of lesion in the post-transplant period would constitute a primary form, whose presentation would be infrequent, corresponding to only 0.45% in the series published to date (6).