The A54T polymorphism in the FABP2 gene and its relationship with obesity
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | eng |
| dc.contributor.author | Torres, Maritza | |
| dc.contributor.author | Prieto, Carem | |
| dc.contributor.author | Ortiz, Rina | |
| dc.contributor.author | Siguencia, Wilson | |
| dc.contributor.author | Durán, Pablo | |
| dc.contributor.author | Pérez, José | |
| dc.contributor.author | Díaz, María P. | |
| dc.contributor.author | Rojas, Milagros | |
| dc.contributor.author | Chacín, Maricarmen | |
| dc.contributor.author | Cano, Clímaco | |
| dc.contributor.author | Bermúdez, Valmore | |
| dc.date.accessioned | 2020-12-16T03:25:27Z | |
| dc.date.available | 2020-12-16T03:25:27Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Introduction: Obesity is a complex, multifactorial, and mostly preventable disease affecting, along with overweight, more than a third of today’s world population. Variations in the nucleotide sequence of both metabolic and appetite control genes have been counted among these non-modifiable factors and are associated with BMI, lipidic profile, and abdominal circumference alterations. Methods: An analytical, non-experimental, and transversal research was done with the purpose to assess the presence of A54T polymorphism in the FABP gene in a sub-sample from the Maracaibo City Metabolic Syndrome Prevalence Study. Results: 154 individuals eight subjects were carriers of the A54Tpolymorphism, namely, a genotypic frequency of 5.19 %, with a sex distribution of 50 % for women (n=4) and 50 % (n=4) for men. In respect of alleles similarity degree, 75 % (n=6) were homozygous, and 25 % (n=2) were heterozygous. Obesity diagnosis throughout BMI was only present in 12.50 % (n=1) of the A54T carriers. Conversely, 25 % (n=2) of the carriers were overweighed; 50 % (n=4) were presented as normal-weight people; and only 12.50 % (n=1), in one underweighted person. Conclusion: As in many other studies, we do not find an association between Ala54Thr polymorphism and obesity. This result reinforces the fact of the multifactorial character of these diseases and a carrier state of this polymorphism is not necessarily to experience a higher obesity risk, at least, in our environment. | eng |
| dc.description.abstract | La obesidad es una enfermedad compleja, multifactorial y en su mayor parte prevenible que afecta, a más de un tercio de la población mundial actual. Las variaciones en la secuencia de nucleótidos de los genes de control del metabolismo y del apetito se consideran hasta ahora como factores no modificables y se asocian con alteraciones del IMC, del perfil lipídico y de la circunferencia abdominal. Métodos: Se realizó una investigación analítica, no experimental y transversal con el propósito de evaluar la presencia del polimorfismo A54T en el gen FABP en una submuestra del Estudio de Prevalencia del Síndrome Metabólico de la Ciudad de Maracaibo. Resultados: De los 154 individuos de la submuestra ocho sujetos fueron portadores del polimorfismo A54T, es decir, una frecuencia genotípica de 5,19 %, con una distribución por sexo de 50 % para las mujeres (n=4) y 50 % (n=4) para los hombres. Con respecto al grado de similitud de los alelos, el 75 % (n=6) eran homocigotos y el 25 % (n=2) heterocigotos. El diagnóstico de obesidad a lo largo del IMC sólo estuvo presente en el 12,50 % (n=1) de los portadores de A54T. Por el contrario, el 25 % (n=2) de los portadores tenían sobrepeso; el 50 % (n=4) se presentaron como personas de peso normal; y sólo el 12,50 % (n=1) en la categoría de peso insuficiente. Conclusión: No se encontró una asociación entre el polimorfismo de Ala54Thr y la obesidad. Este resultado refuerza el carácter multifactorial de estas enfermedades y que un estado portador de este polimorfismo no es causa necesaria para padecer obesidad, al menos, en nuestro medio. | spa |
| dc.format.mimetype | spa | |
| dc.identifier.issn | 03674762 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/6915 | |
| dc.identifier.url | http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/19367 | |
| dc.language.iso | eng | eng |
| dc.publisher | Saber UCV, Universidad Central de Venezuela | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Gaceta Médica de Caracas | spa |
| dc.source | Vol. 128, No. 3 (2020) | |
| dc.subject | Obesity | eng |
| dc.subject | Polymorphism | eng |
| dc.subject | Mutations | eng |
| dc.subject | Cardiovascular diseases | eng |
| dc.subject | Type 2 Diabetes mellitus | eng |
| dc.subject | FABP2 | eng |
| dc.subject | Obesidad | spa |
| dc.subject | Polimorfismo | spa |
| dc.subject | Enfermedades cardiovasculares | spa |
| dc.subject | Diabetes mellitus de tipo 2 | spa |
| dc.title | The A54T polymorphism in the FABP2 gene and its relationship with obesity | eng |
| dc.type.driver | info:eu-repo/semantics/article | eng |
| dc.type.spa | Artículo científico | spa |
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