Logotipo del repositorio
Logotipo del repositorio
 

Asociación entre medidas antropométricas, características demográficas y la severidad de la apnea obstructiva del sueño en adultos atendidos en Barranquilla, 2024–2025

Vista sencilla de ítem
datacite.rightshttp://purl.org/coar/access_right/c_16ec
dc.contributor.advisorUrina Triana, Manuel
dc.contributor.advisorUrina Triana, Miguel
dc.contributor.authorAguilera Caro, Daney Sofia
dc.date.accessioned2026-02-10T14:59:46Z
dc.date.available2026-02-10T14:59:46Z
dc.date.issued2025
dc.description.abstractIntroducción: la apnea obstructiva del sueño (AOS) es uno de los trastornos respiratorios del sueño más prevalentes a nivel mundial y se asocia de manera significativa con morbimortalidad cardiovascular, metabólica y neurocognitiva. Su subdiagnóstico continúa siendo un problema relevante, especialmente en contextos donde el acceso a estudios de sueño es limitado. Las medidas antropométricas y las características demográficas constituyen factores de riesgo ampliamente reconocidos para el desarrollo de AOS; sin embargo, la relación de estas variables con los índices de severidad de la enfermedad ha sido poco documentada en poblaciones locales del Caribe colombiano. Objetivo: evaluar la relación entre las medidas antropométricas y las características demográficas con los índices de severidad de la apnea obstructiva del sueño en pacientes adultos atendidos en una institución de salud de Barranquilla durante los años 2024–2025. Metodología: se realizó un estudio observacional analítico en pacientes adultos con diagnóstico de AOS confirmado mediante polisomnografía o poligrafía respiratoria. Se recolectaron variables demográficas (edad y sexo) y antropométricas (peso, índice de masa corporal y perímetro del cuello). La severidad de la AOS se evaluó a través del índice de apnea-hipopnea (IAH), el tiempo con saturación de oxígeno menor al 90% (T90) y la carga hipóxica. Se analizaron las asociaciones entre estas variables mediante métodos estadísticos apropiados. Resultados: las variables antropométricas y demográficas mostraron asociación con los diferentes índices de severidad de la AOS, evidenciando una relación entre mayor compromiso antropométrico y mayor severidad de la enfermedad. Conclusiones: las medidas antropométricas y las características demográficas se relacionan con la severidad de la apnea obstructiva del sueño en esta población. Estos hallazgos refuerzan la importancia de una adecuada valoración clínica para optimizar la tamización, el diagnóstico oportuno y el abordaje integral de la AOS en el contexto regional.spa
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is one of the most prevalent sleep- related breathing disorders worldwide and is strongly associated with cardiovascular, metabolic, and neurocognitive morbidity. Despite its high prevalence, OSA remains significantly underdiagnosed, particularly in settings with limited access to sleep laboratories. Anthropometric measures and demographic characteristics are well-established risk factors for OSA; however, their relationship with disease severity has been insufficiently characterized in regional populations from the Colombian Caribbean. Objective: To evaluate the association between anthropometric measures and demographic characteristics with severity indices of obstructive sleep apnea in adult patients treated at a healthcare institution in Barranquilla during 2024–2025. Methods: An observational analytical study was conducted in adult patients diagnosed with OSA using polysomnography or respiratory polygraphy. Demographic variables (age and sex) and anthropometric measurements (weight, body mass index, and neck circumference) were collected. OSA severity was assessed using the apnea–hypopnea index (AHI), the percentage of total sleep time with oxygen saturation below 90% (T90), and hypoxic burden. Associations between anthropometric, demographic, and severity variables were analyzed using appropriate statistical methods. Results: Anthropometric and demographic variables showed significant associations with different OSA severity indices, indicating that greater anthropometric compromise was related to increased disease severity. Conclusions: Anthropometric measures and demographic characteristics are associated with the severity of obstructive sleep apnea in this population. These findings highlight the importance of comprehensive clinical assessment to improve screening strategies, facilitate early diagnosis, and support personalized management of OSA in the regional context.eng
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/20.500.12442/17344
dc.language.isospa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad de Ciencias de la Saludspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectApnea obstructiva del sueñospa
dc.subjectAntropometríaspa
dc.subjectGravedad de la enfermedadspa
dc.subject.keywordsObstructive Sleep Apneaeng
dc.subject.keywordsAnthropometryeng
dc.subject.keywordsSeverity of Illness Indexeng
dc.titleAsociación entre medidas antropométricas, características demográficas y la severidad de la apnea obstructiva del sueño en adultos atendidos en Barranquilla, 2024–2025spa
dc.type.driverinfo:eu-repo/semantics/other
dc.type.spaOtros
dcterms.referencesKapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, et al. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: An American academy of sleep medicine clinical practice guideline. Vol. 13, Journal of Clinical Sleep Medicine. American Academy of Sleep Medicine; 2017. p. 479–504. eng
dcterms.referencesGreenstone M, Hack M. Obstructive sleep apnoea. Vol. 348, BMJ (Online). BMJ Publishing Group; 2014. eng
dcterms.referencesGonçalves MT, Malafaia S, Moutinho dos Santos J, Roth T, Marques DR. Epworth sleepiness scale: A meta-analytic study on the internal consistency. Vol. 109, Sleep Medicine. Elsevier B.V.; 2023. p. 261–9. eng
dcterms.referencesArnaud C, Bochaton T, Pépin JL, Belaidi E. Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms. Vol. 113, Archives of Cardiovascular Diseases. Elsevier Masson SAS; 2020. p. 350–8. eng
dcterms.referencesUyar M, Davutoglu V. An update on cardiovascular effects of obstructive sleep apnoea syndrome. Vol. 92, Postgraduate Medical Journal. BMJ Publishing Group; 2016. p. 540–4. eng
dcterms.referencesYoung T, Skatrud J, Peppard PE. Risk Factors for Obstructive Sleep Apnea in Adults [Internet]. Available from: http://jama.jamanetwork.com/ eng
dcterms.referencesNagappa M, Liao P, Wong J, Auckley D, Ramachandran SK, Memtsoudis S, et al. Validation of the stop-bang questionnaire as a screening tool for obstructive sleep apnea among different populations: A systematic review and meta-Analysis. PLoS One. 2015 Dec 1;10(12). eng
dcterms.referencesRoncero A, Castro S, Herrero J, Romero S, Caballero C, Rodriguez P. Obstructive Sleep Apnea. Open Respiratory Archives. 2022 Jul 1;4(3). eng
dcterms.referencesKapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, et al. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: An American academy of sleep medicine clinical practice guideline. Vol. 13, Journal of Clinical Sleep Medicine. American Academy of Sleep Medicine; 2017. p. 479–504. eng
dcterms.referencesMalhotra A, Ayappa I, Ayas N, Collop N, Kirsch D, Mcardle N, et al. Metrics of sleep apnea severity: Beyond the apnea-hypopnea index. Sleep. 2021 Jul 1;44(7). eng
dcterms.referencesLyons MM, Bhatt NY, Pack AI, Magalang UJ. Global burden of sleep-disordered breathing and its implications. Vol. 25, Respirology. Blackwell Publishing; 2020. p. 690–702. eng
dcterms.referencesLabarca G, Henríquez-Beltrán M. How to rate the severity index in obstructive sleep apnea. Revista Medica Clinica Las Condes. 2024 May 1;35(3–4):273–80. eng
dcterms.referencesRamírez Merlano SA, Amado Galeano S, Saracino Freitag D, Cruz HS. Guía para el diagnóstico y el tratamiento de apnea obstructiva del sueño en adultos. ACTA DE OTORRINOLARINGOLOGÍA & CIRUGÍA DE CABEZA Y CUELLO [Internet]. 2024 Dec 23;52(3):169–93. Available from: https://revista.acorl.org.co/index.php/acorl/article/view/815spa
dcterms.referencesLévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, et al. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015 Jun 25;1. eng
dcterms.referencesJordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Vol. 383, The Lancet. Elsevier B.V.; 2014. p. 736–47. eng
dcterms.referencesHidalgo-Martínez P, Lobelo R. Global, latin-american and colombian epidemiology and mortality by obstructive sleep apnea-hypopnea syndrome (OSAHS). Revista Facultad de Medicina. 2017;65(1):S17–20. eng
dcterms.referencesBottia-Córdoba S, Barrios-Bermúdez HP, Rosselli D. Prevalence of Sleep Apnea in Colombia: An Analysis of the Ministry of Health Database. Iatreia. 2024;37(1):26– 34. eng
dcterms.referencesRuiz A, Sepúlveda MAR, Martínez PH, Muñoz MC, Mendoza LO, Centanaro OPP, et al. Prevalence of sleep complaints in Colombia at different altitudes. Sleep Science. 2016 Apr 1;9(2):100–5. eng
dcterms.referencesPeppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal Study of Moderate Weight Change and Sleep-Disordered Breathing [Internet]. Vol. 284, JAMA. 2000. Available from: www.jama.com eng
dcterms.referencesBahammam AS, Hunasikatti M. Progress in Sleep Research Sleep Apnea Frontiers Pathophysiology, Diagnosis, and Treatment Strategies. eng
dcterms.referencesChung F, Abdullah HR, Liao P. STOP-bang questionnaire a practical approach to screen for obstructive sleep apnea. Chest. 2016 Mar 1;149(3):631–8. eng
dcterms.referencesPivetta B, Chen L, Nagappa M, Saripella A, Waseem R, Englesakis M, et al. Use and performance of the STOP-Bang questionnaire for obstructive sleep apnea screening across geographic regions: A systematic review and meta-analysis. Vol. 4, JAMA Network Open. American Medical Association; 2021. eng
dcterms.referencesPedrozo-Pupo JC, Egurrola-Pedraza JA, Campo-Arias A. STOP-Bang as a predictor of obstructive sleep apnea-hypopnea syndrome in outpatients. Duazary. 2021 Nov 15;18(4):344–9. eng
dcterms.referencesMohammadieh A, Sutherland K, Cistulli PA. Sleep disordered breathing: management update. Intern Med J. 2017 Nov 1;47(11):1241–7. eng
dcterms.referencesGuilleminault C, Robinson A. CENTRAL SLEEP APNEA. eng
dcterms.referencesVeasey SC, Rosen IM. Obstructive Sleep Apnea in Adults. New England Journal of Medicine. 2019 Apr 11;380(15):1442–9. eng
dcterms.referencesDempsey JA, Veasey SC, Morgan BJ, O’donnell CP. Pathophysiology of Sleep Apnea. 2010; Available from: www.prv.org eng
dcterms.referencesGuilleminault C, Parejo-Gallardo KJ. History of obstructive sleep apnea-hypopnea syndrome (OSAHS). Revista Facultad de Medicina. 2017;65(1):S11–6. eng
dcterms.referencesBurwell CS, Robin ED, Whaixy? RI), Bickelmann AG. Case Reports Extreme Obesity Associated with Alveolar Hypoventilation-A Pickwickian Syndrome*. eng
dcterms.referencesYoung P, Finn C, Bruetman JE, Emery JDC, Buzzi A. William Osler: el hombre y sus descripciones. Vol. 140, historia de la medicina rev med chile. 2012.spa
dcterms.referencesGuillem Ina U It C, Tilkian A, Dement WC. THE SLEEP APNEA SYNDROMESl [Internet]. 1976. Available from: www.annualreviews.org eng
dcterms.referencesPlaton AL, Stelea CG, Boișteanu O, Patrascanu E, Zetu IN, Roșu SN, et al. An Update on Obstructive Sleep Apnea Syndrome—A Literature Review. Vol. 59, Medicina (Lithuania). Multidisciplinary Digital Publishing Institute (MDPI); 2023. eng
dcterms.referencesRoncero A, Castro S, Herrero J, Romero S, Caballero C, Rodriguez P. Obstructive Sleep Apnea. Open Respiratory Archives. 2022 Jul 1;4(3). eng
dcterms.referencesGottlieb DJ, Punjabi NM. Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA - Journal of the American Medical Association. 2020 Apr 14;323(14):1380–400. eng
dcterms.referencesGomase VG, Deshmukh P, Lekurwale VY. Obstructive Sleep Apnea and Its Management: A Narrative Review. Cureus. 2023 Apr 10; eng
dcterms.referencesYoung T, Skatrud J, Peppard PE. Risk Factors for Obstructive Sleep Apnea in Adults [Internet]. Available from: http://jama.jamanetwork.com/ eng
dcterms.referencesBenjafield A V., Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019 Aug 1;7(8):687–98. eng
dcterms.referencesTerry Young MPJDJSSW and SB. The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults. 1993; eng
dcterms.referencesYoung T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: A population health perspective. Vol. 165, American Journal of Respiratory and Critical Care Medicine. 2002. p. 1217–39. eng
dcterms.referencesDempsey JA, Veasey SC, Morgan BJ, O’donnell CP. Pathophysiology of Sleep Apnea. 2010; Available from: www.prv.org eng
dcterms.referencesLee JJ, Sundar KM. Evaluation and Management of Adults with Obstructive Sleep Apnea Syndrome. Vol. 199, Lung. Springer; 2021. p. 87–101. eng
dcterms.referencesYeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N, et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement from the American Heart Association. Vol. 144, Circulation. Lippincott Williams and Wilkins; 2021. p. E56–67. eng
dcterms.referencesDzierzewski JM, Dautovich N, Ravyts S. Sleep and Cognition in Older Adults. Vol. 13, Sleep Medicine Clinics. W.B. Saunders; 2018. p. 93–106. eng
dcterms.referencesBubu OM, Andrade AG, Umasabor-Bubu OQ, Hogan MM, Turner AD, de Leon MJ, et al. Obstructive sleep apnea, cognition and Alzheimer’s disease: A systematic review integrating three decades of multidisciplinary research. Vol. 50, Sleep Medicine Reviews. W.B. Saunders Ltd; 2020. eng
dcterms.referencesNhlbi, BioLINCC. The Sleep Heart Health Study (SHHS). 2006. eng
dcterms.referencesBonsignore MR, Saaresranta T, Riha RL, Riha R, Bonsignore M. Sex differences in obstructive sleep apnoea. European Respiratory Review. 2019 Dec 31;28(154). eng
dcterms.referencesChoudhury N, Deshmukh P. Obstructive Sleep Apnea in Adults and Ear, Nose, and Throat (ENT) Health: A Narrative Review. Cureus. 2023 Oct 25; eng
dcterms.referencesIsono S. Obesity and obstructive sleep apnoea: Mechanisms for increased collapsibility of the passive pharyngeal airway. Vol. 17, Respirology. 2012. p. 32– 42. eng
dcterms.referencesTangugsorn V, Krogstad O, Espeland L, Lyberg T. Obstructive sleep apnoea: Multiple comparisons of cephalometric variables of obese and non-obese patients. Journal of Cranio-Maxillofacial Surgery. 2000;28(4):204–12. eng
dcterms.referencesNeelapu BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, et al. Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: A systematic review and meta-analysis of cephalometric studies. Vol. 31, Sleep Medicine Reviews. W.B. Saunders Ltd; 2017. p. 79–90. eng
dcterms.referencesShiina K. Obstructive sleep apnea -related hypertension: a review of the literature and clinical management strategy. Hypertension Research. Springer Nature; 2024. eng
dcterms.referencesNamys£owski G, cierski W, Mrówka-Kata K, Kawecka I, Kawecki D, Czecior E. SLEEP STUDY IN PATIENTS WITH OVERWEIGHT AND OBESITY [Internet]. Available from: www.jpp.krakow.pl eng
dcterms.referencesWolk R, Shamsuzzaman ASM, Somers VK. Obesity, Sleep Apnea, and Hypertension. Vol. 42, Hypertension. 2003. p. 1067–74. eng
dcterms.referencesMediano O, González Mangado N, Montserrat JM, Alonso-Álvarez ML, Almendros I, Alonso-Fernández A, et al. Documento internacional de consenso sobre apnea obstructiva del sueño. Arch Bronconeumol. 2022 Jan;58(1):52–68.spa
dcterms.referencesAndrisani G, Andrisani G. Sleep apnea pathophysiology. Vol. 27, Sleep and Breathing. Springer Science and Business Media Deutschland GmbH; 2023. p. 2111–22. eng
dcterms.referencesIngbar DH, Bernard J, Gee L. PATHOPHYSIOLOGY AND TREATMENT OF SLEEP APNEA Further ANNUAL REVIEWS [Internet]. 1985. Available from: www.annualreviews.org eng
dcterms.referencesGarg RK, Afifi AM, Sanchez R, King TW. Obstructive Sleep Apnea in Adults: The Role of Upper Airway and Facial Skeletal Surgery. Plast Reconstr Surg. 2016 Oct 1;138(4):889–98. eng
dcterms.referencesSanjuán Álvarez M, Molano Díaz P, de la Flor Robledo M, Rodríguez Bertos C. Anatomía de la vía aérea: implicaciones anestésicas. Cirugía Mayor Ambulatoria. 2012;17(2).spa
dcterms.referencesKuvat N, Tanriverdi H, Armutcu F. The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk. Vol. 14, Clinical Respiratory Journal. Blackwell Publishing Ltd; 2020. p. 595–604. eng
dcterms.referencesPatel JA, Ray BJ, Fernandez-Salvador C, Gouveia C, Zaghi S, Camacho M. Neuromuscular function of the soft palate and uvula in snoring and obstructive sleep apnea: A systematic review. Vol. 39, American Journal of Otolaryngology - Head and Neck Medicine and Surgery. W.B. Saunders; 2018. p. 327–37. eng
dcterms.referencesde Lucas Ramos Rodríguez González-Moro PJ, de Miguel Díez J. LA VÍA AÉREA SUPERIOR DURANTE EL SUEÑO: FISIOLOGÍA Y FISIOPATOLOGÍA.spa
dcterms.referencesDeak MC, Kirsch DB. Sleep-disordered breathing in neurologic conditions. Vol. 35, Clinics in Chest Medicine. W.B. Saunders; 2014. p. 547–56. eng
dcterms.referencesManresa Presas F. El volumen de cierre (VC) en patología respiratoria. Arch Bronconeumol. 1974;10(1):18–25spa
dcterms.referencesSuzuki M. Obstructive sleep apnea -consideration of its pathogenesis. Vol. 49, Auris Nasus Larynx. Elsevier Ireland Ltd; 2022. p. 313–21. eng
dcterms.referencesGilmartin GS, Thomas RJ. Mechanisms of arousal from sleep and their consequences. 2004. eng
dcterms.referencesEckert DJ, Younes MK. HIGHLIGHTED TOPIC Upper Airway Control and Function: Implications for Sleep-Disordered Breathing Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment. J Appl Physiol [Internet]. 2014;116:302–13. Available from: http://www.jappl.org eng
dcterms.referencesParati G, Lombardi C, Narkiewicz K. Sleep apnea: Epidemiology, pathophysiology, and relation to cardiovascular risk. Vol. 293, American Journal of Physiology - Regulatory Integrative and Comparative Physiology. American Physiological Society; 2007. eng
dcterms.referencesMeliante PG, Zoccali F, Cascone F, Di Stefano V, Greco A, de Vincentiis M, et al. Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea. Vol. 24, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2023. eng
dcterms.referencesBosi M, De Vito A, Gobbi R, Poletti V, Vicini C. The importance of obstructive sleep apnoea and hypopnea pathophysiology for customized therapy. Vol. 274, European Archives of Oto-Rhino-Laryngology. Springer Verlag; 2017. p. 1251–61. eng
dcterms.referencesVarga AW, Mokhlesi B. REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments. Vol. 23, Sleep and Breathing. Springer Verlag; 2019. p. 413–23. eng
dcterms.referencesMay AM, Mehra R. Obstructive sleep apnea: Role of intermittent hypoxia and inflammation. Semin Respir Crit Care Med. 2014;35(5):531–44. eng
dcterms.referencesLavalle S, Masiello E, Iannella G, Magliulo G, Pace A, Lechien JR, et al. Unraveling the Complexities of Oxidative Stress and Inflammation Biomarkers in Obstructive Sleep Apnea Syndrome: A Comprehensive Review. Vol. 14, Life. Multidisciplinary Digital Publishing Institute (MDPI); 2024. eng
dcterms.referencesLavie L. Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea. Vol. 4, Frontiers in Bioscience. 2012. eng
dcterms.referencesJi-Won Lee1* SHBJWJSHK 1 and KWK 1. HIF 1 proteina. Exp Mol Med. 2004 Feb;36:1–12. eng
dcterms.referencesKe Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Vol. 70, Molecular Pharmacology. 2006. p. 1469–80. eng
dcterms.referencesBauters F, Rietzschel ER, Hertegonne KBC, Chirinos JA. The Link Between Obstructive Sleep Apnea and Cardiovascular Disease. Vol. 18, Current Atherosclerosis Reports. Current Medicine Group LLC 1; 2016. p. 1–11. eng
dcterms.referencesStiefel P, Sánchez-Armengol MA, Villar J, Vallejo-Vaz A, Moreno-Luna R, Capote F. Obstructive sleep apnea syndrome, vascular pathology, endothelial function and endothelial cells and circulating microparticles. Vol. 44, Archives of Medical Research. 2013. p. 409–14. eng
dcterms.referencesMalicki M, Karuga FF, Szmyd B, Sochal M, Gabryelska A. Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences. Vol. 13, Metabolites. MDPI; 2023. eng
dcterms.referencesReutrakul S, Mokhlesi B. Obstructive Sleep Apnea and Diabetes: A State of the Art Review. Vol. 152, Chest. Elsevier Inc; 2017. p. 1070–86. eng
dcterms.referencesDrager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: A cardiometabolic risk in obesity and the metabolic syndrome. Vol. 62, Journal of the American College of Cardiology. Elsevier USA; 2013. p. 569–76. eng
dcterms.referencesChasens ER, Imes CC, Kariuki JK, Luyster FS, Morris JL, DiNardo MM, et al. Sleep and Metabolic Syndrome. Vol. 56, Nursing Clinics of North America. W.B. Saunders; 2021. p. 203–17. eng
dcterms.referencesMesarwi OA, Loomba R, Malhotra A. Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease. Vol. 199, American Journal of Respiratory and Critical Care Medicine. American Thoracic Society; 2019. p. 830–41. eng
dcterms.referencesParikh MP, Gupta NM, McCullough AJ. Obstructive Sleep Apnea and the Liver. Vol. 23, Clinics in Liver Disease. W.B. Saunders; 2019. p. 363–82. eng
dcterms.referencesBubu OM, Andrade AG, Umasabor-Bubu OQ, Hogan MM, Turner AD, de Leon MJ, et al. Obstructive sleep apnea, cognition and Alzheimer’s disease: A systematic review integrating three decades of multidisciplinary research. Vol. 50, Sleep Medicine Reviews. W.B. Saunders Ltd; 2020. eng
dcterms.referencesDzierzewski JM, Dautovich N, Ravyts S. Sleep and Cognition in Older Adults. Vol. 13, Sleep Medicine Clinics. W.B. Saunders; 2018. p. 93–106. eng
dcterms.referencesGonzález Mangado N, Monasterio C. 2.1. LA APNEA OBSTRUCTIVA DEL SUEÑO.spa
dcterms.referencesSateia MJ. International classification of sleep disorders-third edition highlights and modifications. Chest. 2014 Nov 1;146(5):1387–94. eng
dcterms.referencesEsteller E, Carrasco M, Díaz-Herrera M, Vila J, Sampol G, Juvanteny J, et al. Clinical practice guideline recommendations on examination of the upper airway for adults with suspected obstructive sleep apnoea-hypopnoea syndrome [Internet]. Vol. 70, Acta Otorrinolaringol Esp. 2019. Available from: www.elsevier.es/otorrino eng
dcterms.referencesNicolás González Mangado JFMJMÁSQ. Material suplementario 2.2 MÉTODOS DIAGNÓSTICOS, Documento internacional de consenso sobre apnea obstructiva del sueño. Arch Bronconeumol. 2022;spa
dcterms.referencesGottlieb DJ, Punjabi NM. Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA - Journal of the American Medical Association. 2020 Apr 14;323(14):1380–400. eng
dcterms.referencesChung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, et al. STOP Questionnaire A Tool to Screen Patients for Obstructive Sleep Apnea [Internet]. Vol. 108, Anesthesiology. 2008. Available from: www.anesthesiology.org. eng
dcterms.referencesGarza-Garibay C, Espinosa-Galindo AM, Palacios D. Use of the Stop-bang questionnaire for the population determination of obstructive sleep apnea in surgical patients Stop-bang questionnaire for determination of OSAS in surgical patients. Medicina Universitaria [Internet]. 2017;19(77):154–8. Available from: www.elsevier.es/rmuanl eng
dcterms.referencesChung F, Subramanyam R, Liao P, Sasaki E, Shapiro C, Sun Y. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth. 2012;108(5):768–75. eng
dcterms.referencesHwang M, Nagappa M, Guluzade N, Saripella A, Englesakis M, Chung F. Validation of the STOP-Bang questionnaire as a preoperative screening tool for obstructive sleep apnea: a systematic review and meta-analysis. BMC Anesthesiol. 2022 Dec 1;22(1). eng
dcterms.referencesNagappa M, Liao P, Wong J, Auckley D, Ramachandran SK, Memtsoudis S, et al. Validation of the stop-bang questionnaire as a screening tool for obstructive sleep apnea among different populations: A systematic review and meta-Analysis. PLoS One. 2015 Dec 1;10(12). eng
dcterms.referencesChiu HY, Chen PY, Chuang LP, Chen NH, Tu YK, Hsieh YJ, et al. Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis. Vol. 36, Sleep Medicine Reviews. W.B. Saunders Ltd; 2017. p. 57–70. eng
dcterms.referencesShahid A, Wilkinson K, Marcu S, Shapiro CM. Berlin Questionnaire. In: STOP, THAT and One Hundred Other Sleep Scales. Springer New York; 2011. p. 71–3. eng
dcterms.referencesNetzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Annals of Internal Medicine Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome [Internet]. Vol. 131. 1999. Available from: http://annals.org/ eng
dcterms.referencesSenaratna C V., Perret JL, Matheson MC, Lodge CJ, Lowe AJ, Cassim R, et al. Validity of the Berlin questionnaire in detecting obstructive sleep apnea: A systematic review and meta-analysis. Vol. 36, Sleep Medicine Reviews. W.B. Saunders Ltd; 2017. p. 116–24. eng
dcterms.referencesRey De Castro J. Validación colombiana de una escala foránea para el Síndrome de Apneas Hipopneas del Sueño (SAHS): el cuestionario de Berlín. Rev Fac Med [Internet]. 2013;61(17):1230–5. Available from: http://dx. eng
dcterms.referencesChai-Coetzer CL, Antic NA, Rowland LS, Catcheside PG, Esterman A, Reed RL, et al. A simplified model of screening questionnaire and home monitoring for obstructive sleep apnoea in primary care. Thorax. 2011;66(3):213–9. eng
dcterms.referencesMarti-Soler H, Hirotsu C, Marques-Vidal P, Vollenweider P, Waeber G, Preisig M, et al. The NoSAS score: a screening tool for sleep disordered breathing in the general population [Internet]. 2015. Available from: http://www.elsevier.com/open- access/userlicense/1.0/ eng
dcterms.referencesRundo JV, Downey R. Polysomnography. In: Handbook of Clinical Neurology. Elsevier B.V.; 2019. p. 381–92. eng
dcterms.referencesVicente S, Manuales M, Aurora ·, López A, Carlos ·, Dos M, et al. Manual básico para técnicos de sueño Universidad Católica de Valencia.spa
dcterms.referencesLeong KW, Griffiths A, Adams AM, Massie J, Kai W, Leong S, et al. How to interpret polysomnography. Arch Dis Child Educ Pract Ed [Internet]. 2019;0:1–6. Available from: http://ep.bmj.com/ eng
dcterms.referencesEstudios diagnósticos en patología del sueño.spa
dcterms.referencesLittner M. Polysomnography in the diagnosis of the obstructive sleep apnea- hypopnea syndrome: Where do we draw the line? Vol. 118, Chest. American College of Chest Physicians; 2000. p. 286–8. eng
dcterms.referencesLittner M. Polysomnography in the diagnosis of the obstructive sleep apnea- hypopnea syndrome: Where do we draw the line? Vol. 118, Chest. American College of Chest Physicians; 2000. p. 286–8. eng
dcterms.referencesGhegan MD, Angelos PC, Stonebraker AC, Gillespie MB. Laboratory versus portable sleep studies: A meta-analysis. Laryngoscope. 2006 Jun;116(6):859–64. eng
dcterms.referencesFerrer A. Alternativas a la polisomnografía convencional en el diagnóstico y tratamiento del síndrome de apneas durante el sueño. Vol. 31, Archivos de bronconeumología. 1995. p. 259–63.spa
dcterms.referencesMasa JF, Corral J, Pereira R, Duran-Cantolla J, Cabello M, Hernández-Blasco L, et al. Effectiveness of home respiratory polygraphy for the diagnosis of sleep apnoea and hypopnoea syndrome. Thorax. 2011;66(7):567–73. eng
dcterms.referencesFlemons WW, Littner MR, Rowley JA, Gay P, Anderson WMD, Hudgel DW, et al. Home Diagnosis of Sleep Apnea: A Systematic Review of the Literature - An Evidence Review Cosponsored by the American Academy of Sleep Medicine, the American College of Chest Physicians, and the American Thoracic Society. Vol. 124, Chest. American College of Chest Physicians; 2003. p. 1543–79. eng
dcterms.referencesJavier F, Cuesta P, Arboledas GP, Santa J, Cano M, Durán-Cantolla J. DOCUMENTO DE CONSENSO NACIONAL SOBRE EL SÍNDROME DE APNEAS-HIPOPNEAS DEL SUEÑO (SAHS) REALIZADO POR EL GRUPO ESPAÑOL DE SUEÑO (GES) COMITÉ DE REDACCIÓN Asociación ibérica de Patología del Sueño (AIPS) Asociación Española de Pediatría (AEP) Sociedad Española de Neurología (SEN) COORDINADOR Sociedad Española de Neumología y Cirugía Torácica (SEPAR).spa
dcterms.referencesSystematic Review and Meta-analysis of the Literature Regarding the Diagnosis of Sleep Apnea. eng
dcterms.referencesShayeb M El, Topfer LA, Stafinski T, Pawluk L, Menon D. Diagnostic accuracy of level 3 portable sleep tests versus level 1 polysomnography for sleep-disordered breathing: A systematic review and meta-analysis. CMAJ Canadian Medical Association Journal. 2014 Jan 7;186(1). eng
dcterms.referencesCorral J, Sanchez-Quiroga MA, Carmona-Bernal C, Sanchez-Armengol A, De La Torre AS, Duran-Cantolla J, et al. Conventional polysomnography is not necessary for the management of most patients with suspected obstructive sleep apnea noninferiority, randomized controlled trial. Am J Respir Crit Care Med. 2017 Nov 1;196(9):1181–90. eng
dcterms.referencesSchnall RP, Sheffy J (Koby), Penzel T. Peripheral arterial tonometry–PAT technology. Vol. 61, Sleep Medicine Reviews. W.B. Saunders Ltd; 2022. eng
dcterms.referencesPenzel T, Fricke R, Jerrentrup A, Peter JH, Vogelmeier C. PERIPHERAL ARTERIAL TONOMETRY FOR THE DIAGNOSIS OF OBSTRUCTIVE SLEEP APNEA. eng
dcterms.referencesMasa JF, Corral J, Pereira R, Duran-Cantolla J, Cabello M, Hernández-Blasco L, et al. Therapeutic decision-making for sleep apnea and hypopnea syndrome using home respiratory polygraphy: A large multicentric study. Am J Respir Crit Care Med. 2011 Oct 15;184(8):964–71. eng
dcterms.referencesRosen CL, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Kapur V, et al. A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: The HomePAP study. Sleep. 2012 Jun 1;35(6):757–67. eng
dcterms.referencesLi Chai-Coetzer C, Antic NA, Sharn Rowland L, Richard Reed MnL, Esterman A, Catcheside PG, et al. Primary Care vs Specialist Sleep Center Management of Obstructive Sleep Apnea and Daytime Sleepiness and Quality of Life A Randomized Trial [Internet]. Available from: http://jama.jamanetwork.com/ eng
dcterms.referencesSusan D. Ross MD FIASMKJHBMKMMJECBSASP and IEAP. Systematic Review and Meta-analysis of the Literature Regarding the Diagnosis of Sleep Apnea. Sleep. 2000;23. eng
dcterms.referencesGuillem Ina U It C, Tilkian A, Dement WC. THE SLEEP APNEA SYNDROMESl [Internet]. 1976. Available from: www.annualreviews.org eng
dcterms.referencesRuehland WR, Rochford PD, Dip Bio Instr G, O FJ, Pierce RJ, singh P, et al. The New AAsm Criteria for scoring Hypopneas: Impact on the Apnea Hypopnea Index [Internet]. Vol. 32, SLEEP. 2009. Available from: https://academic.oup.com/sleep/article-abstract/32/2/150/3741711 eng
dcterms.referencesLandry SA, Beatty C, Thomson LDJ, Wong AM, Edwards BA, Hamilton GS, et al. A review of supine position related obstructive sleep apnea: Classification, epidemiology, pathogenesis and treatment. Vol. 72, Sleep Medicine Reviews. W.B. Saunders Ltd; 2023. eng
dcterms.referencesSaraç S, Afsar GC. Effect of mean apnea-hypopnea duration in patients with obstructive sleep apnea on clinical and polysomnography parameter. Sleep and Breathing. 2020 Mar 1;24(1):77–81. eng
dcterms.referencesPien GW, Ye L. Chapter 130 - Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea. Principles and Practice of Sleep Medicine - 2 Volume Set. 2022. eng
dcterms.referencesLabarca G, Campos J, Thibaut K, Dreyse J, Jorquera J. Do T90 and SaO2 nadir identify a different phenotype in obstructive sleep apnea? Sleep and Breathing. 2019 Sep 1;23(3):1007–10. eng
dcterms.referencesCoso C, Solano-Pérez E, Romero-Peralta S, Castillo-García M, Silgado-Martínez L, López-Monzoni S, et al. The Hypoxic Burden, Clinical Implication of a New Biomarker in the Cardiovascular Management of Sleep Apnea Patients: A Systematic Review. Rev Cardiovasc Med. 2024 May 1;25(5). eng
dcterms.referencesParekh A. Hypoxic burden – definitions, pathophysiological concepts, methods of evaluation, and clinical relevance. Vol. 30, Current Opinion in Pulmonary Medicine. Lippincott Williams and Wilkins; 2024. p. 600–6. eng
dcterms.referencesMartinez-Garcia MA, Sánchez-De-La-Torre M, White DP, Azarbarzin A, Ángel Martínez-García M. Hypoxic burden in obstructive sleep apnea: present and future. 2022. eng
dcterms.referencesZeng W, Wu S, Liu Z, Yuan L, Chen B, Rong Y. Hypoxic Burden and T90% as Predictive Indicators of Cardiovascular Risk and Myocardial Ischemia in Patients with Obstructive Sleep Apnea. Nat Sci Sleep. 2025;17:1557–70. eng
dcterms.referencesAzarbarzin A, Sands SA, Stone KL, Taranto-Montemurro L, Messineo L, Terrill PI, et al. The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: The Osteoporotic Fractures in Men Study and the Sleep Heart Health Study. Eur Heart J. 2019 Apr 7;40(14):1149–1157a. eng
dcterms.referencesArqueros López A, Dos Santos Pires Claro Teixeira CM, Martínez Miralpeix M, Minguez Rouré O, Molina Sánchez T, Pastor Campo A, Perez Martí M, Sahab Shashani A, Sánchez-Ferragut Amorós G, Torrent Cortés S. Manual de la Sociedad Española del Sueño. 1ª ed. España: Universidad Católica de Valencia San Vicente Mártir; 2024. eng
dcterms.referencesCho JH, Choi JH, Suh JD, Ryu S, Cho SH. Comparison of anthropometric data between asian and caucasian patients with obstructive sleep apnea: A meta- analysis. Vol. 9, Clinical and Experimental Otorhinolaryngology. Korean Society of Otolaryngology; 2016. p. 1–7. eng
dcterms.referencesGüneş ZY, Günaydın FM, Yıldırım S. Comparisons of obstructive – central respiratory events with body mass index and neck-waist circumference measurements according to gender in patients with obstructive sleep apnea syndrome. Sleep and Breathing. 2025 Dec 1;29(6). eng
dcterms.referencesMediano O, González Mangado N, Montserrat JM, Alonso-Álvarez ML, Almendros I, Alonso-Fernández A, et al. Documento internacional de consenso sobre apnea obstructiva del sueño. Arch Bronconeumol. 2022 Jan;58(1):52–68.spa
dcterms.referencesRamírez Merlano SA, Amado Galeano S, Saracino Freitag D, Cruz HS. Guía para el diagnóstico y el tratamiento de apnea obstructiva del sueño en adultos. ACTA DE OTORRINOLARINGOLOGÍA & CIRUGÍA DE CABEZA Y CUELLO. 2024 Dec 23;52(3):169–93.spa
dcterms.referencesSmith PL, Gold AR, Meyers DA, Haponik EF, Bleecker ER;, Baltimore M. Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep Apnea [Internet]. Available from: http://annals.org/ eng
dcterms.referencesChirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R, et al. CPAP, Weight Loss, or Both for Obstructive Sleep Apnea. New England Journal of Medicine. 2014 Jun 12;370(24):2265–75. eng
dcterms.referencesMalhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A, et al. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. New England Journal of Medicine. 2024 Oct 3;391(13):1193–205. eng
dcterms.referencesGuardiano SA, Scott JA, Ware JC, Schechner SA. The Long-term Results of Gastric Bypass on Indexes of Sleep Apnea. Chest. 2003;124(4):1615–9. eng
dcterms.referencesJavier F, Cuesta P, Arboledas GP, Santa J, Cano M, Durán-Cantolla J. DOCUMENTO DE CONSENSO NACIONAL SOBRE EL SÍNDROME DE APNEAS-HIPOPNEAS DEL SUEÑO (SAHS) REALIZADO POR EL GRUPO ESPAÑOL DE SUEÑO (GES) COMITÉ DE REDACCIÓN Asociación ibérica de Patología del Sueño (AIPS) Asociación Española de Pediatría (AEP) Sociedad Española de Neurología (SEN) COORDINADOR Sociedad Española de Neumología y Cirugía Torácica (SEPAR).spa
dcterms.referencesNicolás González Mangado. 2.4.A. Tratamiento médico de la apnea obstructiva del sueño ANEXOS BRONCONEUMOLOGIA. 2022;spa
dcterms.referencesWeaver TE, Mancini C, Maislin G, Cater J, Staley B, Landis JR, et al. Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: Resultsof the CPAP apnea trial north american program (CATNAP) randomized clinical trial. Am J Respir Crit Care Med. 2012 Oct 1;186(7):677–83. eng
dcterms.referencesBarnes M, McEvoy RD, Banks S, Tarquinio N, Murray CG, Vowles N, et al. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. Am J Respir Crit Care Med. 2004 Sep 15;170(6):656–64. eng
dcterms.referencesMcEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, et al. CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea. New England Journal of Medicine. 2016 Sep 8;375(10):919–31. eng
dcterms.referencesHoyos CM, Killick R, Yee BJ, Phillips CL, Grunstein RR, Liu PY. Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: A randomised sham-controlled study. Thorax. 2012;67(12):1081–9. eng
dcterms.referencesSutherland K, Vanderveken OM, Tsuda H, Marklund M, Gagnadoux F, Kushida CA, et al. Oral appliance treatment for obstructive sleep apnea: An update. Vol. 10, Journal of Clinical Sleep Medicine. 2014. p. 215–27. eng
dcterms.referencesVenema JAMU, Rosenmöller BRAM, de Vries N, de Lange J, Aarab G, Lobbezoo F, et al. Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment. Vol. 60, Sleep Medicine Reviews. W.B. Saunders Ltd; 2021. eng
dcterms.referencesMarklund M, Verbraecken J, Randerath W. Non-CPAP therapies in obstructive sleep apnoea: Mandibular advancement device therapy. Vol. 39, European Respiratory Journal. 2012. p. 1241–7. eng
dcterms.referencesJorquera J, Salas-Cossio C, Oyarzo JF, Pacheco C, Del Favero M, Sánchez M. Treatment options for mild and moderate obstructive sleep apnea. Revista Medica Clinica Las Condes. 2024 May 1;35(3–4):281–9. eng
dcterms.referencesOn SW, Kim DK, Lee MH, Lee JH, Lee KC, Byun SH, et al. Clinical efficacy study of position-responding mandibular advancement device in patients with obstructive sleep apnea. Clin Exp Otorhinolaryngol. 2024 Nov 30; eng
dcterms.referencesOu YH, Colpani JT, Cheong CS, Loke W, Thant A tar, Shih EC, et al. Mandibular Advancement vs CPAP for Blood Pressure Reduction in Patients With Obstructive Sleep Apnea. J Am Coll Cardiol. 2024 May 7;83(18):1760–72. eng
dcterms.referencesLyons-Coleman M, Bates C, Barber S. Obstructive sleep apnoea and the role of the dental team. Br Dent J. 2020 May 1;228(9):681–5. eng
dcterms.referencesChen H, Eckert DJ, van der Stelt PF, Guo J, Ge S, Emami E, et al. Phenotypes of responders to mandibular advancement device therapy in obstructive sleep apnea patients: A systematic review and meta-analysis. Vol. 49, Sleep Medicine Reviews. W.B. Saunders Ltd; 2020. eng
dcterms.referencesNeelapu BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, et al. Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: A systematic review and meta-analysis of cephalometric studies. Vol. 31, Sleep Medicine Reviews. W.B. Saunders Ltd; 2017. p. 79–90. eng
dcterms.referencesOn SW, Kim DK, Lee MH, Lee JH, Lee KC, Byun SH, et al. Clinical Efficacy of a Position-Responding Mandibular Advancement Device in Patients With Obstructive Sleep Apnea. Clin Exp Otorhinolaryngol. 2024 Nov 1;17(4):302–9. eng
dcterms.referencesCamacho M, Certal V, Abdullatif J, Zaghi S, Ruoff CM, Capasso R, et al. Myofunctional therapy to treat obstructive sleep apnea: A systematic review and meta-analysis. Sleep. 2015 May 1;38(5):669–75. eng
dcterms.referencesRueda JR, Mugueta-Aguinaga I, Vilaró J, Rueda-Etxebarria M. Myofunctional therapy (oropharyngeal exercises) for obstructive sleep apnoea. Vol. 2020, Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd; 2020. eng
dcterms.referencesde Felício CM, Dias FV da S, Trawitzki LVV. Obstructive sleep apnea: Focus on myofunctional therapy. Vol. 10, Nature and Science of Sleep. Dove Medical Press Ltd; 2018. p. 271–86. eng
dcterms.referencesNicolás González Mangado. 2.4.C Tratamiento quirúrgico de la Apnea Obstructiva del Sueño. Material suplementario. Bronconeumologia. eng
dcterms.referencesAskar SM, Khazbak AO, Mobasher MA, Abd Al Badea AM, Abu Sharkh AA, Awad AM. Role of DISE in the surgical outcome for patients with obstructive sleep apnea. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2023 Jul 1;44(4). eng
dcterms.referencesDe Vito A, Cammaroto G, Chong KB, Carrasco-Llatas M, Vicini C. Drug-induced sleep endoscopy: Clinical application and surgical outcomes. Healthcare (Switzerland). 2019 Sep 1;7(3). eng
dcterms.referencesGarg RK, Afifi AM, Sanchez R, King TW. Obstructive Sleep Apnea in Adults: The Role of Upper Airway and Facial Skeletal Surgery. Plast Reconstr Surg. 2016 Oct 1;138(4):889–98. eng
dcterms.referencesRamírez Merlano SA, Amado Galeano S, Saracino Freitag D, Cruz HS. Guía para el diagnóstico y el tratamiento de apnea obstructiva del sueño en adultos. ACTA DE OTORRINOLARINGOLOGÍA & CIRUGÍA DE CABEZA Y CUELLO. 2024 Dec 23;52(3):169–93.spa
dcterms.referencesLi KK, Kushida C, Powell NB, Riley RW, Guilleminault C. Obstructive sleep apnea syndrome: A comparison between far-east asian and white men. Laryngoscope. 2000;110(10):1689–93. eng
oaire.versioninfo:eu-repo/semantics/acceptedVersion
sb.programaEspecialización en Cardiologíaspa
sb.sedeSede Barranquillaspa

Archivos

Bloque original
Mostrando 1 - 2 de 2
No hay miniatura disponible
Nombre:
PDF.pdf
Tamaño:
855.73 KB
Formato:
Adobe Portable Document Format
Descargar
No hay miniatura disponible
Nombre:
PDF_Resumen.pdf
Tamaño:
306.71 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.93 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Especialización

Universidad Simón Bolívar: Todos los derechos reservados / Sistema de biblioteca