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Kidney-gut crosstalk in renal disease

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datacite.rightshttp://purl.org/coar/access_right/c_16ecspa
dc.contributor.authorColombo, Iara
dc.contributor.authorAiello-Battan, Florencia
dc.contributor.authorRosario Elena
dc.contributor.authorRuiz, Agustina
dc.contributor.authorPetraglia, Lucas
dc.contributor.authorMusso, Carlos G.
dc.date.accessioned2020-11-26T15:54:44Z
dc.date.available2020-11-26T15:54:44Z
dc.date.issued2020
dc.description.abstractIntroduction The colon has an important role in managing nitrogenous waste products, electrolytes, and mineral balance during kidney diseases. However, colonic microbiota produces uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, in chronic kidney disease (CKD) patients, which due to their proinflammatory properties contribute to CKD progression. Conversely, in acute renal injury patients, intestinal microbiota could reduce inflammation by secreting short-chain fatty acids and inducing a renal protective immune response. However, since the intestines are the most frequently affected organ in advanced sepsis, colonic microbiota can also represent a negative factor for kidney health in this scenario. Conclusion In the present review, the main characteristics of kidney-gut crosstalk are described.eng
dc.format.mimetypepdfeng
dc.identifier.doihttps://doi.org/10.1007/s11845-020-02437-7
dc.identifier.isbn00211265
dc.identifier.urihttps://hdl.handle.net/20.500.12442/6815
dc.language.isoengeng
dc.publisherSpringer Natureeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceIrish Journal of Medical Scienceeng
dc.sourceVol. 189, No. 5, (2020)
dc.subjectCrosstalkeng
dc.subjectGuteng
dc.subjectKidneyeng
dc.titleKidney-gut crosstalk in renal diseaseeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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