Papel de las grasas esenciales en los procesos inflamatorios asociados a la artritis reumatoide
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Fecha
2018
Autores
Carrero, Carmen María
Oróstegui, María Alejandra
Ruiz Escorcia, Linda
Aldana, Edna
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Editor
Sociedad Venezolana de Farmacología y de Farmacología Clínica y Terapéutica
Resumen
La artritis reumatoidea (AR) corresponde a un complejo desorden
autoinmune que se caracteriza por una marcada inflamación
y destrucción progresiva de los tejidos que forman
las articulaciones. El tratamiento médico está dirigido a la supresión
del proceso inflamatorio mitigando así los síntomas y
signos de la enfermedad.
La intervención nutricional basada
en alimentos fuentes de ácidos grasos poliinsaturados (AGPICL
ω-3) como: pescados, salmón, trucha, arenque, sardina,
atún, anchoas, pez espada actúan como coadyuvantes en el
tratamiento de enfermedades de base inflamatoria. El objetivo
de este estudio fue analizar la evidencia disponible sobre
los efectos terapéuticos de los ácidos grasos poliinsaturados
en el estado inflamatorio crónico y en la sintomatología en
pacientes con AR. La revisión consistió en la búsqueda bibliográfica
en el 2017, con escritos en español o ingles publicados
en las bases de datos Medline, Cochrane, Scopus,
Sportdiscus y Amed, entre 2001 y 2017. Se demostró que los
ácidos grasos esenciales en la artritis reumatoide evidencian
reducción del dolor en articulaciones, y/o inflamadas, de la
rigidez matutina. Los efectos producidos por el consumo en
la alimentación de ácidos grasos esenciales, resulta ser útil
como tratamiento de la inflamación aguda y crónica y la disminución
de las dosis de AINES.
Rheumatoid arthritis (RA) corresponds to a complex autoimmune disorder characterized by marked inflammation and progressive destruction of the tissues that form the joints. Medical treatment is aimed at suppressing the inflammatory process, thus mitigating the symptoms and signs of the disease. The nutritional intervention based on food sources of polyunsaturated fatty acids (AGPICL ω-3) such as: fish, salmon, trout, herring, sardines, tuna, anchovies, swordfish act as coadjuvants in the treatment of inflammatory-based diseases. The objective of this study was to analyze the available evidence on the therapeutic effects of polyunsaturated fatty acids in the chronic inflammatory state and in the symptomatology in patients with RA. The review consisted of bibliographic search in 2017, with writtings in Spanish or English published in the databases Medline, Cochrane, Scopus, Sportdiscus and Amed, between 2001 and 2017. It was demonstrated that essential fatty acids in rheumatoid arthritis show reduced pain in joints, and/or inflamed, of morning stiffness. The effects produced by the consumption in the feeding of essential fatty acids, it is useful as treatment of acute and chronic inflammation and the decrease of the doses of NSAIDs.
Rheumatoid arthritis (RA) corresponds to a complex autoimmune disorder characterized by marked inflammation and progressive destruction of the tissues that form the joints. Medical treatment is aimed at suppressing the inflammatory process, thus mitigating the symptoms and signs of the disease. The nutritional intervention based on food sources of polyunsaturated fatty acids (AGPICL ω-3) such as: fish, salmon, trout, herring, sardines, tuna, anchovies, swordfish act as coadjuvants in the treatment of inflammatory-based diseases. The objective of this study was to analyze the available evidence on the therapeutic effects of polyunsaturated fatty acids in the chronic inflammatory state and in the symptomatology in patients with RA. The review consisted of bibliographic search in 2017, with writtings in Spanish or English published in the databases Medline, Cochrane, Scopus, Sportdiscus and Amed, between 2001 and 2017. It was demonstrated that essential fatty acids in rheumatoid arthritis show reduced pain in joints, and/or inflamed, of morning stiffness. The effects produced by the consumption in the feeding of essential fatty acids, it is useful as treatment of acute and chronic inflammation and the decrease of the doses of NSAIDs.
Descripción
Palabras clave
Ácidos Grasos, Artritis Reumatoide, Procesos Inflamatorios, Fatty acids, Rheumatoid arthritis, Inflammatory Processes