Características clínico-patológicas de la podocitopatía por glomeruloesclerosis focal y segmentariapor microscopia electrónica en la región caribe colombiana
| datacite.rights | http://purl.org/coar/access_right/c_16ec | spa |
| dc.contributor.advisor | Aroca Martínez, Gustavo José | |
| dc.contributor.advisor | Guido Musso, Carlos | |
| dc.contributor.advisor | González Torres, Henry J. | |
| dc.contributor.author | Sepúlveda Ospino, Carlos José | |
| dc.date.accessioned | 2024-01-19T22:13:05Z | |
| dc.date.available | 2024-01-19T22:13:05Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Glomeruloesclerosis focal y segmentaria, también es llamada hialinosis focal y segmentaria, hace referencia a un patrón histológico, pero que indica un síndrome clínico patológico, siendo este una característica posiblemente de seis etiologías subyacentes distintas que como se ha venido mencionando lo característico que se va a observar es la cicatrización del glomérulo de forma progresiva, de tal forma que estas etiologías comparten un tema común de lesión y depleción de los podocitos, lo que se concluye no es una enfermedad única, sino un patrón morfológico de lesión que se desarrolla a partir de una amplia gama de etiologías. Objetivo: Evaluar las características clínico-patológicas de la podocitopatía por glomeruloesclerosis focal y segmentaria por microscopia electrónica en la región caribe colombiana Métodos: Se presentaron las variables cuantitativas como medianas y rangos intercuartílicos, mientras que las variables categóricas se describieron con frecuencias absolutas y relativas. El análisis incluyó pruebas como el test de Wilcoxon para las medianas según el sexo y la prueba exacta de Fisher para variables categóricas. Se empleó análisis de correspondencia múltiple para explorar relaciones entre hallazgos de microscopía y variables clínicas. La normalidad se evaluó con la prueba de Shapiro-Wilk, considerando p < 0.05 como significativo. Se utilizó el software R-CRAN versión 4.3.2 para los análisis estadísticos. | spa |
| dc.description.abstract | Focal segmental glomerulosclerosis, also known as focal and segmental hyalinosis, refers to a histological pattern indicating a clinical-pathological syndrome. This pattern is likely a characteristic of six distinct underlying etiologies. As previously mentioned, the common feature observed is progressive glomerular scarring. These etiologies share a common theme of podocyte injury and depletion, suggesting it is not a singular disease but a morphological pattern arising from a wide range of causes. Objective: To evaluate Clinical-pathological characteristics of podocytopathy due to focal segmental glomerulosclerosis by electron microscopy in the Colombian Caribbean region. Methods: Quantitative variables were presented as medians and interquartile ranges, while categorical variables were described using absolute and relative frequencies. Analysis included tests such as the Wilcoxon rank-sum test for medians by gender and Fisher's exact test for categorical variables. Multiple correspondence analysis explored relationships between microscopy findings and clinical variables. Data normality was assessed with the Shapiro-Wilk test, considering p < 0.05 as significant. Statistical analyses were performed using R-CRAN software version 4.3.2. | eng |
| dc.format.mimetype | spa | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/13829 | |
| dc.language.iso | spa | spa |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias de la Salud | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Glomeruloesclerosis focal y segmentaria | spa |
| dc.subject | Microscopia electrónica | spa |
| dc.subject | Rubulopatía | spa |
| dc.subject | Focal segmental glomerulosclerosis | eng |
| dc.subject | Electron microscopy | eng |
| dc.subject | Tubulopathy | eng |
| dc.title | Características clínico-patológicas de la podocitopatía por glomeruloesclerosis focal y segmentariapor microscopia electrónica en la región caribe colombiana | spa |
| dc.type.driver | info:eu-repo/semantics/other | spa |
| dc.type.spa | Otros | spa |
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| oaire.version | info:eu-repo/semantics/acceptedVersion | spa |
| sb.programa | Especialización en Nefrología | spa |
| sb.sede | Sede Barranquilla | spa |