Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure

datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
dc.contributor.authorTorres-Ávila, Jose F.
dc.contributor.authorEspitia-Pérez, Lyda
dc.contributor.authorBonatto, Diego
dc.contributor.authorRabaioli da Silva, Fernanda
dc.contributor.authorMarques de Oliveira, Iuri
dc.contributor.authorSilva, Luís F.O.
dc.contributor.authorSilva Corrêa, Dione
dc.contributor.authorFerraz Dias, Johnny
dc.contributor.authorda Silva, Juliana
dc.contributor.authorPêgas Henriques, João Antonio
dc.date.accessioned2020-07-05T14:20:33Z
dc.date.available2020-07-05T14:20:33Z
dc.date.issued2020
dc.description.abstractCell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role.eng
dc.format.mimetypepdfspa
dc.identifier.doihttp://dx.doi.org/10.1590/1678-4685-gmb-2019-0134
dc.identifier.issn16784685
dc.identifier.urihttps://hdl.handle.net/20.500.12442/6152
dc.language.isoengeng
dc.publisherSociedade Brasileira de Genéticaspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceGenetics and Molecular Biologyeng
dc.sourceVol. 43 N° 3, (2020)
dc.subjectCoaleng
dc.subjectCell cycleeng
dc.subjectSystems chemo-biologyeng
dc.titleSystems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposureeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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