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Las dislipidemias y su tratamiento en centros de altacomplejidad en Colombia

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dc.contributor.authorRuiz, Álvaro J.
dc.contributor.authorVargas-Uricoechea, Hernando
dc.contributor.authorUrina-Triana, Miguel
dc.contributor.authorRomán-González, Alejandro
dc.contributor.authorIsazae, Daniel
dc.contributor.authorEtayof, Edwin
dc.contributor.authorQuintero, Adalberto
dc.contributor.authorMolina, Dora Inés
dc.contributor.authorToro, Juan Manuel
dc.contributor.authorParra, Gustavo
dc.contributor.authorMerchán, Alonso
dc.contributor.authorCadena, Alberto
dc.contributor.authorYupanqui Lozano, Hernán
dc.contributor.authorCárdenas, Juan Mauricio
dc.contributor.authorQuintero, Álvaro Mauricio
dc.contributor.authorBotero, Rodrigo
dc.contributor.authorJaramillo, Mónica
dc.contributor.authorArteaga, Juan Manuel
dc.contributor.authorVesga-Angaritar, Boris
dc.contributor.authorValenzuela-Plata, Etna
dc.contributor.authorBetancur-Valencia, Mónica
dc.date.accessioned2020-05-23T19:37:26Z
dc.date.available2020-05-23T19:37:26Z
dc.date.issued2020
dc.description.abstractAntecedentes y objetivo: Los datos sobre la distribución de las dislipidemias en Colombia sonlimitados. El objetivo primario de este estudio fue describir la frecuencia de las dislipidemias; los objetivos secundarios fueron: la frecuencia de comorbilidades cardiovasculares, el uso de estatinas y otros hipolipemiantes, la frecuencia de intolerancia a estatinas, el porcentaje de pacientes en metas de c-LDL, y estimar la distribución del riesgo cardiovascular (RCV).Materiales y métodos: Estudio transversal con recolección de datos retrospectiva que incluyóa 461 pacientes con diagnóstico de dislipidemia tratados en 17 centros cardiovasculares de altacomplejidad en las 6 principales áreas geográficas y económicas de Colombia.Resultados: La media (DE) de edad de los pacientes incluidos fue de 66,4 (±12,3) a˜nos. El 53,4%(246) eran mujeres. Las dislipidemias se distribuyeron así: dislipidemia mixta (51,4%), hiperco-lesterolemia (41,0%), hipertrigliceridemia (5,4%), hipercolesterolemia familiar (3,3%) y c-HDLbajo (0,7%). El medicamento más prescrito fue atorvastatina (75,7%), seguido de rosuvastatina(24,9%). El 55% del total de pacientes y el 28,6% de aquellos con enfermedad coronaria noestaban en metas de c-LDL a pesar del tratamiento. La frecuencia de intolerancia a estatinas fue del 2,6%.Conclusiones: La dislipidemia mixta y la hipercolesterolemia son las dislipidemias más frecuentes. Un porcentaje considerable de pacientes en tratamiento, incluidos aquellos con enfermedad coronaria, no lograron sus objetivos de c-LDL. Este inadecuado control lipídicoinfluye en el RCV y requiere un cambio en las estrategias terapéuticas, intensificando el trata-miento con estatinas o adicionando nuevos fármacos en los pacientes con mayor RCV.© 2020 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. Todos los derechos reservados.spa
dc.description.abstractBackground and objective: Data is scarce on the distribution of different types of dyslipidae-mia in Colombia. The primary objective was to describe the frequency of dyslipidaemias. Thesecondary objectives were: frequency of cardiovascular comorbidity, statins and other lipid-lowering drugs use, frequency of statins intolerance, percentage of patients achieving c-LDLgoals, and distribution of cardiovascular risk (CVR).Materials and methods: Cross-sectional study with retrospective data collection from 461patients diagnosed with dyslipidaemia and treated in 17 highly specialised centres distributedinto six geographic and economic regions of Colombia.Results: Mean (SD) age was 66.4 (±12.3) years and 53.4% (246) were women. Dyslipidaemiaswere distributed as follows in order of frequency: mixed dyslipidaemia (51.4%), hypercholes-terolaemia (41.0%), hypertriglyceridaemia (5.4%), familial hypercholesterolaemia (3.3%), andlow c-HDL (0.7%). The most prescribed drugs were atorvastatin (75.7%) followed by rosuvas-tatin (24.9%). As for lipid control, 55% of all patients, and 28.6% of those with coronary heartdisease, did not achieve their personal c-LDL goal despite treatment. The frequency of statinintolerance was 2.6% in this study.Conclusions: Mixed dyslipidaemia and hypercholesterolaemia are the most frequent dyslipidae-mias in Colombia. A notable percentage of patients under treatment with lipid-lowering drugs,including those with coronary heart disease, did not achieve specific c-LDL goals. This poor lipidcontrol may worsen patient’s CVR, so that therapeutic strategies need to be changed, eitherwith statin intensification or addition of new drugs in patients with higher CVR.© 2020 Sociedad Espa˜nola de Arteriosclerosis. Published by Elsevier Espa˜na, S.L.U. All rightsreserved.eng
dc.format.mimetypepdfspa
dc.identifier.doihttps://doi.org/10.1016/j.arteri.2019.11.005
dc.identifier.issn15781879
dc.identifier.urihttps://hdl.handle.net/20.500.12442/5732
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0214916820300036?via%3Dihub
dc.language.isospaspa
dc.publisherSociedad Espanola de Arteriosclerosisspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceClínica e investigación en Arteriosclerosisspa
dc.sourceVol. 3, (2020)
dc.subjectAterosclerosisspa
dc.subjectEnfermedad cardiovascularspa
dc.subjectDislipidemiaspa
dc.subjectEstatinasspa
dc.subjectHipercolesterolemia familiarspa
dc.subjectAtherosclerosiseng
dc.subjectCardiovascular diseaseeng
dc.subjectDyslipidaemiaeng
dc.subjectStatinseng
dc.subjectFamilial hypercholesterolaemiaeng
dc.titleLas dislipidemias y su tratamiento en centros de altacomplejidad en Colombiaspa
dc.typearticleeng
dc.type.driverarticleeng
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