Insulin resistance indices and coronary risk in adults from Maracaibo city, Venezuela: A cross sectional study [version 1; referees: 1 approved with reservations]
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Fecha
2018-03
Autores
Salazar, Juan
Bermúdez, Valmore
Olivar, Luis Carlos
Torres, Wheeler
Palmar, Jim
Añez, Roberto
Ordoñez, Maria Gratzia
Rivas, José Ramón
Martínez, María Sofía
Hernández, Juan Diego
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is published by F1000 Research Ltd
Resumen
Background: Insulin resistance (IR) is a metabolic disorder related to
atherosclerosis. Its measurement is of great importance not only as a marker of
diabetes but also for cardiovascular disease. The aim of this research study
was to evaluate the relationship between various IR indices and coronary risk in
an adult population from Maracaibo city, Venezuela.
Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a
descriptive, cross-sectional study with random and multi-stage sampling. In this
sub study, 1272 individuals of both genders were selected with the
measurement of basal insulin and coronary risk according to the
Framingham-Wilson formula calibrated for our population. The insulin
resistance indices evaluated were HOMA2-IR, triglycerides and glucose index
(TyG) and triglycerides/HDL ratio (TG/HDL). The predictive capacity and
association between each index and the coronary risk event in 10 years were
determined.
Results: Of the evaluated population, 55.2% were female, 34.8% had a
coronary risk ≥5% in 10 years, with the TG/HDL and TyG indices showing the
highest AUC 0.712 (0.681-0.743) and 0.707 (0.675-0.739), respectively;
compared to HOMA2-IR. Both were also the indices most associated with
increased coronary risk, especially TG/HDL ≥3 with a higher association [OR =
2.83 (1.74-4.61); p<0.01] after multivariable adjustment.
Conclusions: TyG (≥4.5) and TG/HDL (≥3) indices showed a great predictive
capacity of higher coronary risk, with being TG/HDL more associated even after
adjusting for abdominal obesity and hs-CRP. Therefore, these represent useful
tools for determining IR.
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Palabras clave
Insulin resistance, Coronary risk, Triglycerides, HOMA2-IR, HDL-C