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Anticuerpos contra el virus del dengue en pacientes con dislipidemias

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorGotera, Jennifer
dc.contributor.authorValero, Nereida
dc.contributor.authorÁvila, Ayari
dc.contributor.authorLinares, Johan
dc.contributor.authorMosquera, Jesús
dc.contributor.authorBermúdez, Valmore
dc.contributor.authorVeliz, Teresa
dc.date.accessioned2020-12-18T04:39:09Z
dc.date.available2020-12-18T04:39:09Z
dc.date.issued2019
dc.description.abstractEl objetivo fue comparar los anticuerpos IgG e IgM contra el virus del dengue en pacientes con dislipidemias. Tipo de estudio descriptivo, prospectivo de diseño no experimental, de corte transversal. La muestra estuvo constituida por 214 individuos, distribuidos en 169 con dislipidemias y 45 controles. Los lípidos séricos y los anticuerpos anti-dengue se determinaron mediante métodos bioquímicos e inmunológicos convencionales. Se clasificaron en 3 grupos: hipertriacilgliceridemia (279,7±84,2 mg/dl); hipercolesterolemia (252,7±38,5 mg/dl) y el grupo con triacilglicéridos y colesterol elevados (257,3±38,5; 271,6±88,7 mg/dl). El 96% de los pacientes resultó con inmunidad (IgG) contra el virus del dengue, la respuesta primaria (IgM) estuvo presente en un 22%. En cuanto a la positividad de IgM, la mayor frecuencia estuvo en el grupo con hipertriacilgliceridemia (34,2%), mientras que la frecuencia para la IgG estuvo en el grupo con triacilglicéridos y colesterol elevados (31,2%). En este estudio no se observó diferencia entre los anticuerpos IgG e IgM contra virus del dengue en los pacientes con dislipidemias y el grupo control. Se necesitan futuros estudios para evidenciar en áreas de menor endemia para el virus del dengue si efectivamente la alteración del perfil lipídico modifica la intensidad de respuesta ante la infección.spa
dc.description.abstractThe objective was to compare the antibodies against the dengue virus in patients with different types of dyslipidemias. Type of descriptive, prospective study of non-experimental, cross-sectional design. The sample consisted of 214 individuals, distributed in 169 with dyslipidemias and 45 controls. Serum lipids and anti-dengue antibodies were determined by conventional biochemical and immunological methods. They were classified into 3 groups: hypertriacilgliceridemia (279.7 ± 84.2 mg / dl); hypercholesterolemia (252.7 ± 38.5 mg / dl) and the group with high triglycerides and cholesterol (257.3 ± 38.5, 271.6 ± 88.7 mg / dl). 96% of the patients showed immunity (IgG) against dengue virus, the primary response (IgM) was present in 22%. Regarding the positivity of IgM, the highest frequency was in the group with hypertriacilgliceridemia (34.2%), while the frequency for IgG was in the group with triacylglycerides and high cholesterol (31.2%). In this study, no difference was observed between IgG and IgM antibodies against dengue virus in patients with dyslipidemia and the control group. Future studies are needed to demonstrate in areas of lower endemicity for the dengue virus if, in fact, the alteration of the lipid profile modifies the intensity of response to the infection.eng
dc.format.mimetypepdfspa
dc.identifier.doihttps://doi.org/10.5281/zenodo.3479187
dc.identifier.issn24779628
dc.identifier.urihttps://hdl.handle.net/20.500.12442/6936
dc.identifier.urlhttps://produccioncientificaluz.org/index.php/kasmera/article/view/29647
dc.language.isospaspa
dc.publisherUniversidad del Zulia. Sistema de Servicios Bibliotecarios y de Informaciónspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceRevista KASMERAspa
dc.sourceVol. 47, No. 2 (2019)spa
dc.subjectVirologíaspa
dc.subjectDenguespa
dc.subjectDislipidemiasspa
dc.subjectInmunidadspa
dc.subjectAnticuerposspa
dc.subjectImmunityeng
dc.subjectAntibodieseng
dc.titleAnticuerpos contra el virus del dengue en pacientes con dislipidemiasspa
dc.title.translatedAntibodies against dengue virus in patients with dislipidemiaseng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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