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New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorGonzález-Casanova, Jorge Enrique
dc.contributor.authorDurán-Agüero, Samuel
dc.contributor.authorCaro-Fuentes, Nelson Javier
dc.contributor.authorGamboa-Arancibia, Maria Elena
dc.contributor.authorTamara, Bruna
dc.contributor.authorBermúdez, Valmore
dc.contributor.authorRojas-Gómez, Diana Marcela
dc.date.accessioned2023-08-19T20:13:30Z
dc.date.available2023-08-19T20:13:30Z
dc.date.issued2021
dc.description.abstractDue to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biological regulation of adipose tissue is of fundamental relevance. Connexin, a protein that forms intercellular membrane channels of gap junctions and unopposed hemichannels, plays a key role in adipogenesis and in the maintenance of adipose tissue homeostasis. The expression and function of Connexin 43 (Cx43) during the different stages of the adipogenesis are differentially regulated. Moreover, it has been shown that cell–cell communication decreases dramatically upon differentiation into adipocytes. Furthermore, inhibition of Cx43 degradation or constitutive overexpression of Cx43 blocks adipocyte differentiation. In the first events of adipogenesis, the connexin is highly phosphorylated, which is likely associated with enhanced Gap Junction (GJ) communication. In an intermediate state of adipocyte differentiation, Cx43 phosphorylation decreases, as it is displaced from the membrane and degraded through the proteasome; thus, Cx43 total protein is reduced. Cx is involved in cardiac disease as well as in obesity-related cardiovascular diseases. Different studies suggest that obesity together with a high-fat diet are related to the production of remodeling factors associated with expression and distribution of Cx43 in the atrium.eng
dc.format.mimetypepdfeng
dc.identifier.citationGonzález-Casanova, J.E.; Durán-Agüero, S.; Caro-Fuentes, N.J.; Gamboa-Arancibia, M.E.; Bruna, T.; Bermúdez, V.; Rojas-Gómez, D.M. New Insights on the Role of Connexins and Gap Junctions Channels in Adipose Tissue and Obesity. Int. J. Mol. Sci. 2021, 22, 12145. https://doi.org/10.3390/ijms222212145eng
dc.identifier.doihttps://doi.org/10.3390/ijms222212145
dc.identifier.issn14220067
dc.identifier.urihttps://hdl.handle.net/20.500.12442/13166
dc.language.isoengeng
dc.publisherMDPIeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceInternational Journal of Molecular Scienceseng
dc.sourceVol. 20 Issue 22 (2021)eng
dc.subjectConnexinseng
dc.subjectGap junctions channelseng
dc.subjectAdipose tissueeng
dc.subjectObesityeng
dc.subjectCardiovascular diseaseseng
dc.titleNew insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesityeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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