Logotipo del repositorio
Logotipo del repositorio
 

Evaluación de la correlación la dosis de diálisis (Kt/V) y el estatus de fragilidad en el paciente crónico dializado

Vista sencilla de ítem
datacite.rightshttp://purl.org/coar/access_right/c_16ecspa
dc.contributor.advisorAroca Martínez, Gustavospa
dc.contributor.advisorGuido Musso, Carlosspa
dc.contributor.authorHernández Agudelo, Sandra Yolima
dc.contributor.authorMaya Altamiranda, Lina Paola
dc.date.accessioned2020-11-05T22:06:41Z
dc.date.available2020-11-05T22:06:41Z
dc.date.issued2020
dc.description.abstractIntroducción: la fragilidad es un síndrome multicausal caracterizado por una disminución de fuerza, resistencia y función fisiológica, lo que hace al individuo vulnerable y dependiente, y aumenta su mortalidad. Este síndrome es más frecuente entre las personas mayores y los pacientes con enfermedad renal crónica, particularmente aquellos en diálisis. La dosis de diálisis está estandarizada actualmente para pacientes en hemodialálisis (HD) independientemente de su edad y estado funcional. Sin embargo, se ha postulado que la dosis de diálisis requerida en pacientes mayores, especialmente los frágiles, debe ser menor, ya que podría aumentar su grado de fragilidad. Entonces, el propósito de este estudio fue evaluar si habría una correlación entre la dosis de Kt / V y el grado de fragilidad en un población de pacientes adultos en HD. Material y métodos: un estudio transversal con 82 pacientes en HD en Barranquilla (Colombia) y Lobos (Argentina). Se registraron datos sociodemográficos y de laboratorio, así como dosis de diálisis (Kt / V) y se aplicaron escalas de fragilidad, actividad física, marcha y fuerza de agarre. Entonces estos los datos se correlacionaron mediante una correlación de Spearman y una regresión logística. Resultados: SFC, aislamiento social, actividad física, velocidad de la marcha y pruebas de fuerza prensil fueron fuera de los rangos de referencia en el grupo estudiado. No se encontró correlación significativa entre la dosis de diálisis y todas las pruebas funcionales mencionadas anteriormente. Sin embargo, fue documentó una correlación significativa e inversa entre la actividad física y el síndrome de fatiga crónica (puntuación -1,41 (IC: -2,1 a -0,7). En conclusión: no hubo correlación significativa documentado entre el valor Kt / V y diferentes parámetros del estado de fragilidad, pero esto el estado se correlacionó de manera significativa e inversa con la actividad física en este grupo. Fragilidad El estado de los pacientes en hemodiálisis fue significativamente mayor en las personas mayores, aunque los jóvenes no estaban exentos de ella.spa
dc.description.abstractIntroduction: Frailty is a multicausal syndrome characterized by a decrease in strength, resistance and physiological function, which makes the individual vulnerable and dependent, and increases his/her mortality. This syndrome is more prevalent among older individuals, and chronic kidney disease patients, particularly those on dialysis. Dialysis dose is currently standardized for hemodiallysis (HD) patients regardless their age and functional status. However, it has been postulated that the dialysis dose required in older patients, especially frail ones, should be lower, since it could increase their degree of frailty. Then, the purpose of this study was to evaluate if there would be a correlation between the dose of Kt/V and the degree of frailty in a population of adult patients on HD. Material & methods: A cross-sectional study with 82 patients on HD in Barranquilla (Colombia) and Lobos (Argentina) was conducted. Socio-demographic and laboratory data, as well as dialysis doses (Kt/V) were recorded and scales of fragility, physical activity, gait and grip strength were applied. Then these data were correlated by a Spearman’s correlation and a logistic regression. Results: CFS, social isolation, physical activity, gait speed, and prehensile strength tests were outside the reference ranges in the studied group. No significant correlation was found between dialysis dose and all the above mentioned functional tests. However, it was documented a significant and inverse correlation between physical activity and CFS (score -1.41 (CI: -2.1 to -0.7). In conclusion: no significant correlation was documented between Kt/V value and different parameters of the frailty status, but this status correlated significantly and inversely with physical activity in this group. Frailty status in hemodialysis patients was significantly higher in older individuals, although young individuals were not exempt from iteng
dc.format.mimetypepdfspa
dc.identifier.urihttps://hdl.handle.net/20.500.12442/6769
dc.language.isospaspa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad de Ciencias de la Saludspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFragilidadspa
dc.subjectDosis de diálisisspa
dc.subjectHemodiálisisspa
dc.subjectFrailtyeng
dc.subjectDialysis doseeng
dc.subjectHemodialysis.eng
dc.titleEvaluación de la correlación la dosis de diálisis (Kt/V) y el estatus de fragilidad en el paciente crónico dializadospa
dc.type.driverinfo:eu-repo/semantics/otherspa
dc.type.spaOtrosspa
dcterms.referencesProietti M, Cesari M. Frailty: What Is It? 2020. 1–7. doi:10.1007/978-3-030- 33330-0_1eng
dcterms.referencesTabue-Teguo M, Simo N, Gonzalez-Colaço Harmand M, et al. Frailty in elderly: a brief review. Geriatr Psychol Neuropsychiatr Vieil 2017;15:127–37. doi:10.1684/pnv.2017.0670eng
dcterms.referencesCesari M, Calvani R, Marzetti E. Frailty in Older Persons. Clin Geriatr Med 2017;33:293–303. doi:10.1016/j.cger.2017.02.002eng
dcterms.referencesCesari M, Marzetti E, Thiem U, et al. The geriatric management of frailty as paradigm of ‘The end of the disease era’. Eur J Intern Med 2016;31:11–4. doi:10.1016/j.ejim.2016.03.005eng
dcterms.referencesCesari M, Prince M, Thiyagarajan JA, et al. Frailty: An Emerging Public Health Priority. J Am Med Dir Assoc 2016;17:188–92. doi:10.1016/j.jamda.2015.12.016eng
dcterms.referencesLee L, Heckman G, Molnar FJ. Frailty: Identifying elderly patients at high risk of poor outcomes. Can Fam Physician 2015;61:227– 31.http://www.ncbi.nlm.nih.gov/pubmed/25767167eng
dcterms.referencesWon CW. Frailty: Its Scope and Implications for Geriatricians. Ann Geriatr Med Res 2019;23:95–7. doi:10.4235/agmr.19.0032eng
dcterms.referencesCesari M, Vellas B. Frailty in Clinical Practice. Nestle Nutr Inst Workshop Ser 2015;83:93–8. doi:10.1159/000382091eng
dcterms.referencesMorley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc 2013;14:392–7. doi:10.1016/j.jamda.2013.03.022eng
dcterms.referencesCesari M, Vellas B, Gambassi G. The stress of aging. Exp Gerontol 2013;48:451–6. doi:10.1016/j.exger.2012.10.004eng
dcterms.referencesHenchoz Y, Büla C, Guessous I, et al. Association between Physical Frailty and Quality of Life in a Representative Sample of Community-Dwelling Swiss Older People. J Nutr Health Aging 2017;21:585–92. doi:10.1007/s12603- 016-0772-4eng
dcterms.referencesClegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet (London, England) 2013;381:752–62. doi:10.1016/S0140-6736(12)62167-9eng
dcterms.referencesSubra J, Gillette-Guyonnet S, Cesari M, et al. The integration of frailty into clinical practice: preliminary results from the Gérontopôle. J Nutr Health Aging 2012;16:714–20. doi:10.1007/s12603-012-0391-7eng
dcterms.referencesProietti M, Cesari M. Frailty: What Is It? Adv Exp Med Biol 2020;1216:1–7. doi:10.1007/978-3-030-33330-0_1eng
dcterms.referencesMendiratta P, Latif R. Clinical Frailty Scale. 2020. http://www.ncbi.nlm.nih.gov/pubmed/32644435eng
dcterms.referencesRockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005;173:489–95. doi:10.1503/cmaj.050051eng
dcterms.referencesDuke D. Measuring frailty in geriatric patients. CMAJ 2006;174:352–3; author reply 353. doi:10.1503/cmaj.1050199eng
dcterms.referencesWoo J, Leung J, Morley JE. Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation. J Am Geriatr Soc 2012;60:1478–86. doi:10.1111/j.1532- 5415.2012.04074.xeng
dcterms.referencesRockwood K, Theou O. Using the Clinical Frailty Scale in Allocating Scarce Health Care Resources. Can Geriatr J 2020;23:210–5. doi:10.5770/cgj.23.463eng
dcterms.referencesLemus-Barrios GA, Morales-Benavidez DC, López-Salazar AM, et al. Evaluación de la fragilidad en la enfermedad cardiovascular: Un reto necesario | Assessment of frailty in cardiovascular disease: A necessary challenge. Rev Colomb Cardiol 2020;27:283–93. doi:10.1016/j.rccar.2019.12.015eng
dcterms.referencesHatheway OL, Mitnitski A, Rockwood K. Frailty affects the initial treatment response and time to recovery of mobility in acutely ill older adults admitted to hospital. Age Ageing 2017;46:920–5. doi:10.1093/ageing/afw257eng
dcterms.referencesTheou O, Squires E, Mallery K, et al. What do we know about frailty in the acute care setting? A scoping review. BMC Geriatr 2018;18:139. doi:10.1186/s12877-018-0823-2eng
dcterms.referencesPulok MH, Theou O, van der Valk AM, et al. The role of illness acuity on the association between frailty and mortality in emergency department patients referred to internal medicine. Age Ageing 2020;49:1071–9. doi:10.1093/ageing/afaa089eng
dcterms.referencesLang P-O, Michel J-P, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology 2009;55:539–49. doi:10.1159/000211949eng
dcterms.referencesLi H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis 2011;2:466–73.http://www.ncbi.nlm.nih.gov/pubmed/22396895eng
dcterms.referencesVatic M, von Haehling S, Ebner N. Inflammatory biomarkers of frailty. Exp Gerontol 2020;133:110858. doi:10.1016/j.exger.2020.110858eng
dcterms.referencesWang GC, Casolaro V. Immunologic changes in frail older adults. Transl Med @ UniSa 2014;9:1–6.http://www.ncbi.nlm.nih.gov/pubmed/24809027eng
dcterms.referencesAiello F, Dueñas E, Musso C. Senescent Nephropathy: The New Renal Syndrome. Healthcare 2017;5:81. doi:10.3390/healthcare5040081eng
dcterms.referencesMusso CG, Jauregui JR, Macías Núñez JF. Frailty phenotype and chronic kidney disease: a review of the literature. Int Urol Nephrol 2015;47:1801–7. doi:10.1007/s11255-015-1112-zeng
dcterms.referencesAatif T, Hassani K, Alayoud A, et al. Quantification of Hemodialysis Dose: What Kt/V to Choose? Int J Artif Organs 2014;37:29–38. doi:10.5301/ijao.5000236eng
dcterms.referencesMusso CG, Schwartz P, Deira J, et al. Is It Correct to Use a Unique Conventional Dialysis Prescription in the Elderly? Four Alternative Schedules for Dialyzing Elderly Patients. Int J Ren Dis Ther 2018;1. doi:10.31021/ijrdt.20181103eng
dcterms.referencesMusso CG, Vilas M. Nephroprevention in the very old patient. Rev Colomb Nefrol 2015;2:131–6. doi:10.22265/acnef.2.2.213eng
oaire.versioninfo:eu-repo/semantics/submittedVersionspa
sb.programaEspecialización en Medicina Internaspa
sb.sedeSede Barranquillaspa

Archivos

Colecciones

Especialización

Universidad Simón Bolívar: Todos los derechos reservados / Sistema de biblioteca