WCN26-3469 Binutuzumab induces histologic remission and deep kidney parenchymal b-cell depletion in patients with lupus nephritis: exploratory analyses from the regency trial
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.contributor.author | Rovin, Brad H. | |
| dc.contributor.author | Martins, Elsa | |
| dc.contributor.author | Austin, Cary D. | |
| dc.contributor.author | Raghu, Harini | |
| dc.contributor.author | Chan, Caleb | |
| dc.contributor.author | Chang, Patrick | |
| dc.contributor.author | Alberton, Valeria | |
| dc.contributor.author | Santiago, Mittermayer | |
| dc.contributor.author | Aroca-Martinez, Gustavo | |
| dc.contributor.author | Alfaro, Jose | |
| dc.contributor.author | Furie, Richard A. | |
| dc.contributor.author | Larson, Christopher | |
| dc.contributor.author | Yoo, Bongin | |
| dc.contributor.author | Pendergraft, William F. | |
| dc.contributor.author | Malvar, Ana | |
| dc.date.accessioned | 2026-04-06T19:46:27Z | |
| dc.date.available | 2026-04-06T19:46:27Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | The REGENCY trial (NCT04221477) demonstrated superiority of obinutuzumab (OBI) plus standard therapy (+ST) vs placebo (PBO) +ST in achieving complete renal response (CRR) at Week 76 (W76) in adults with active lupus nephritis (LN). It was postulated that OBI+ST would yield greater rates of histologic remission and kidney tissue-level B-cell depletion at W76 than PBO+ST, which would portend more favorable long-term kidney outcomes, such as reduced LN flare risk and preserved kidney function. These exploratory analyses aimed to evaluate histologic remission and kidney tissue-level B-cell depletion at W76 in patients treated with OBI+ST vs PBO+ST. | eng |
| dc.format.mimetype | ||
| dc.identifier.doi | https://doi.org/10.1016/j.ekir.2026.106200 | |
| dc.identifier.issn | 24680249 (Electrónico) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/17494 | |
| dc.identifier.url | https://www.kireports.org/article/S2468-0249(26)02431-9/fulltext | |
| dc.language.iso | eng | |
| dc.publisher | International Society of Nephrology ISN | eng |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.keywords | Lupus nephritis | eng |
| dc.subject.keywords | B lymphocytes | eng |
| dc.title | WCN26-3469 Binutuzumab induces histologic remission and deep kidney parenchymal b-cell depletion in patients with lupus nephritis: exploratory analyses from the regency trial | eng |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.spa | Artículo científico | |
| oaire.version | info:eu-repo/semantics/publishedVersion | |
| sb.sede | Sede Barranquilla | spa |