Superinfecciones en pacientes con Covid-19 grave asociado al uso de glucocorticoides en unidad de cuidados intensivos en una clínica de Pasto (NAR, COL)
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Fecha
2023
Autores
Rúales Chamorro, Miguel Ángel
Rosero Erazo, Eduin Andrés
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
La pandemia por SARS-CoV-2 causó gran impacto en la forma de realizar abordaje del paciente críticamente enfermo. Muchos de los pacientes al inicio de la pandemia fueron tratados de manera empírica, lo que conllevo al uso de algunas terapéuticas no evaluadas en su totalidad en el impacto en el desarrollo de otras complicaciones. Este fue el caso de los corticoides.
Objetivo: Evaluar la posible relación entre las infecciones y superinfecciones en pacientes con SARS-CoV-2 grave, con el uso de corticoides previo en los pacientes remitidos a una Unidad de Cuidados Intensivos en una clínica de Pasto (NAR, CO), durante el periodo de abril a agosto de 2020.
Metodología: Se realizó un estudio corte transversal de los pacientes que utilizaron corticoides antes de ingresar a la UCI adultos por SARS-CoV-2. Para ello se realizaron estadística descriptiva de los datos recogidos en una UCI de Pasto y se realizó un resumen de los datos, se realizaron asociaciones con χ² o Test Exacto de Fisher según el caso. Se calculó el OR para establecer los niveles de riesgo a un desenlace con relación a uso o no de corticoides.
The SARS-CoV-2 pandemic has had a significant impact on the approach to critically ill patients. Many patients at the beginning of the pandemic were empirically treated, leading to the use of some therapies that were not fully evaluated for their impact on the development of other complications. This was the case with corticosteroids. Objective: To evaluate the association between infections and superinfections in patients with severe SARS-CoV-2 and prior corticosteroid use among patients referred to an Intensive Care Unit (ICU) in a clinic in Pasto (NAR, CO) between april to august 2020. Methods: An analytical study was conducted on patients who received corticosteroids before admission to the ICU for severe SARS-CoV-2 infection. Descriptive statistics were performed on the data collected in a Pasto ICU, and a summary of the data was generated. Associations were assessed using χ² or Fisher's exact test as appropriate. Odds ratios (OR) were calculated to establish the risk levels associated with corticosteroid use or non-use in relation to outcomes.
The SARS-CoV-2 pandemic has had a significant impact on the approach to critically ill patients. Many patients at the beginning of the pandemic were empirically treated, leading to the use of some therapies that were not fully evaluated for their impact on the development of other complications. This was the case with corticosteroids. Objective: To evaluate the association between infections and superinfections in patients with severe SARS-CoV-2 and prior corticosteroid use among patients referred to an Intensive Care Unit (ICU) in a clinic in Pasto (NAR, CO) between april to august 2020. Methods: An analytical study was conducted on patients who received corticosteroids before admission to the ICU for severe SARS-CoV-2 infection. Descriptive statistics were performed on the data collected in a Pasto ICU, and a summary of the data was generated. Associations were assessed using χ² or Fisher's exact test as appropriate. Odds ratios (OR) were calculated to establish the risk levels associated with corticosteroid use or non-use in relation to outcomes.
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Palabras clave
SARS-Covid, Superinfecciones, SDRA, Corticoides, Mortalidad, SARS-CoV-2, Superinfections, ARDS, Corticosteroids, Mortality
