Polimorfismo -159 del receptor CD14 asociado al asma bronquial atópica y no atópica en población adulta
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Fecha
2015
Autores
Cano Orrego, Juan Daniel
Fernández Jiménez, Fernán Enrique
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
El asma es una enfermedad inflamatoria de las vías respiratorias la cual es desencadenada por múltiples factores como el genético, dentro de este se encuentran polimorfismos en proteínas que participan en la respuesta inflamatoria, como es el caso del polimorfismo de un solo nucleótido (SNP) en el receptor CD14 (polimorfismo C-159T). La presente revisión bibliográfica se basó en varias fuentes documentales durante el último año como New England Journal of Medicine, The Journal of the American Medical Association, British Medical Journal, CHEST Journal, The Lancet,. Se utilizaron además los motores de búsqueda científicos Virtual Reference Library, ProQuest, Ovid y Science Direct, a través de la combinación de las diferentes palabras clave. Los registros obtenidos fueron de 300 artículos de los cuales 50 fueron seleccionados (33 en idioma ingles y 17 en idioma español) estos cumplieron con el criterio de inclusión de informar sobre el polimorfismo -159 del receptor CD 14 asociado al asma bronquial atópica y no atópica en población adulta.
Finalmente se concluye la presente revisión bibliográfica afirmando que si existe una asociación directa del polimorfismo -159 del receptor CD14 con el asma bronquial atópica y no atópica en la población adulta en diferentes poblaciones.
Asthma is an inflammatory disease of the airways which is triggered by multiple factors including genetic, within this polymorphisms in proteins involved in the inflammatory response are, as in the case of the polymorphism of a single nucleotide (SNP) in the CD14 receptor (polymorphism C-159T). This revision was based on several documentary sources over the last year as New England Journal of Medicine, The Journal of the American Medical Association, the British Medical Journal, CHEST Journal, The Lancet, using descriptors: scientific writing, editing, concept maps , critical reading. Scientific search engines Virtual Reference Library, ProQuest, Ovid and Science Direct were also used, through the combination of different keywords. The records obtained were 300 articles of which 50 were selected (33 in English and 17 in Spanish) met these inclusion criteria of reporting the -159 polymorphism of the CD14 receptor associated with bronchial asthma in atopic and non-atopic adult population. Finally this literature review concludes by saying that if there is a direct association of CD14 receptor -159 polymorphism with atopic and non-atopic asthma in adults in different populations. Also it could describe the phenotypic and allelic frequency of the aforementioned polymorphism.
Asthma is an inflammatory disease of the airways which is triggered by multiple factors including genetic, within this polymorphisms in proteins involved in the inflammatory response are, as in the case of the polymorphism of a single nucleotide (SNP) in the CD14 receptor (polymorphism C-159T). This revision was based on several documentary sources over the last year as New England Journal of Medicine, The Journal of the American Medical Association, the British Medical Journal, CHEST Journal, The Lancet, using descriptors: scientific writing, editing, concept maps , critical reading. Scientific search engines Virtual Reference Library, ProQuest, Ovid and Science Direct were also used, through the combination of different keywords. The records obtained were 300 articles of which 50 were selected (33 in English and 17 in Spanish) met these inclusion criteria of reporting the -159 polymorphism of the CD14 receptor associated with bronchial asthma in atopic and non-atopic adult population. Finally this literature review concludes by saying that if there is a direct association of CD14 receptor -159 polymorphism with atopic and non-atopic asthma in adults in different populations. Also it could describe the phenotypic and allelic frequency of the aforementioned polymorphism.
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Palabras clave
Polimorfismo -159, Asma bronquial, CD14, Atopia, Inmunoglobulina, -159 polymorphism, Bronchial asthma, Atopy, Immunoglobulin
