Overlap syndrome in late-onset systemic lupus erythematosus with lupus nephritis and MPO-ANCA pauci-immune glomerulonephritis and tuberculosis: an uncommon association

datacite.rightshttp://purl.org/coar/access_right/c_abf2
dc.contributor.authorDulce Muñoz, Jaime Arturo
dc.contributor.authorAroca-Martinez, Gustavo
dc.contributor.authorSeni, Christian
dc.contributor.authorPerea Rojas, Diana Marcela
dc.contributor.authorCABARCAS BARBOSA, OMAR
dc.contributor.authorNiño Hernández, Lucia Mercedes
dc.contributor.authorGaivao Arciniegas, Dario Jose
dc.contributor.authorGarcía Jarava, Camila Maria
dc.contributor.authorOlivares Olmos, Marianela
dc.contributor.authorSeni Hernandez, Sebastian Andre
dc.contributor.authorPérez Jiménez, Valentina
dc.contributor.authorRojas-Torres, Indiana-Luz
dc.date.accessioned2025-03-05T14:42:02Z
dc.date.available2025-03-05T14:42:02Z
dc.date.issued2025
dc.description.abstractSystemic lupus erythematosus is a systemic autoimmune pathology that generally presents in young people and manifests acutely, while its late presentation in people over 50 years of age is rare and insidious. Vasculitis is a pathology that afects any vessel producing fbrinoid necrosis, and presents with a positive antineutrophil cytoplasmic antibody. Te concomitance of these two entities is rare and leads to worse clinical outcomes. We present a 73-year-old female patient who presented with rapidly progressive glomerulonephritis requiring renal replacement therapy, pulmonary tuberculosis, late-onset lupus erythematosus with lupus nephritis, and a positive result for neutrophil cytoplasmic antibody. An immune-mediated extracapillary proliferative glomerulonephritis was found when the biopsy was performed, with obvious signs of vasculitis, an overlap syndrome was found between these entities. She was initially treated with antituberculosis therapy, boluses of methylprednisolone and continued with intermittent renal replacement therapy; however, due to the severity of his pathologies, she had a fatal outcome. Te concomitance between these autoimmune pathologies is unusual; there is a late-onset overlap syndrome between lupus nephritis accompanied by myeloperoxidase-antineutrophil cytoplasmic antibody and pauci-immune glomerulonephritis. Te dual presentation es tablishes clinical challeng.spa
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/crin/5285961
dc.identifier.issn20906641 (Impreso)
dc.identifier.issn2090665X (Electrónico)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/16340
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1155/crin/5285961
dc.language.isoeng
dc.publisherWileyspa
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United Stateseng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.sourceCase Reports in Nephrologyeng
dc.subjectANCAspa
dc.subject.keywordsANCAeng
dc.subject.keywordsANCA-associated vasculitiseng
dc.subject.keywordsAntibodieseng
dc.subject.keywordsAntineutrophil cytoplasmiceng
dc.subject.keywordsGlomerulonephritiseng
dc.subject.keywordsErythematosuseng
dc.subject.keywordsLupus nephritiseng
dc.subject.keywordsMPOeng
dc.subject.keywordsMyeloperoxidaseeng
dc.subject.keywordsSystemiceng
dc.subject.keywordsVasculitiseng
dc.titleOverlap syndrome in late-onset systemic lupus erythematosus with lupus nephritis and MPO-ANCA pauci-immune glomerulonephritis and tuberculosis: an uncommon associationspa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.spaArtículo científico
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