Sociodemogra phic, clinical, and laboratory profiles of patients with early- versus late-onset systemic lupus erythematosus. A single-center observational study in the Colombian Caribbean
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Fecha
2025
Autores
Aroca-Martinez, Gustavo
Pérez Jiménez, Valentina
Raad Sarabia, Maria Isabel
Perea Rojas, Diana Marcela
Guido Musso, Carlos
Depine, Santos
Pérez Velásquez, Jorge Andrés
Perez Correa, Juan Camilo
Aroca, María Paula
Cadena Bonfanti, Andres Angélo
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Sociedad Ecuatoriana de Nefrología, Diálisis y Transplantes
Resumen
Introduction: Late-onset systemic lupus erythematosus (SLE) is a rare form of
this disease characterized by atypical clinical manifestations and a high burden of
comorbidities, making it challenging to diagnose and manage patients in time. The
objective of this study was to compare the sociodemographic, clinical, and paraclinical
characteristics, as well as the therapeutic outcomes, of patients with earlyand
late-onset SLE in a reference center in the Colombian Caribbean.
Methods: This was an observational, descriptive, and cross-sectional study based
on a review of medical records from the RENELUP database (2010–2024). Patients
aged ≥18 years who met the 2019 EULAR/ACR criteria were included. Chisquare,
Fisher's, and Student's T tests were applied.
Results: A total of 282 patients were analyzed: 235 (83%) with early-stage SLE
and 47 (17%) with late-stage SLE. Females predominated (89% and 81%, respectively).
Patients with late-stage SLE had higher proteinuria (2,900 vs. 662 mg/24
h; P<0.001) and lower HDL levels (41 vs. 48 mg/dl; P=0.038).
There were no significant differences in remission or mortality, although mortality was higher for late-stage disease (20.7% vs.
10.1%).
Conclusion: Patients with late SLE had a lower frequency of typical clinical manifestations, including mucocutaneous, joint, and
hematological involvement. In terms of renal involvement, patients with late SLE had a higher burden of proteinuria, with no
statistically significant differences in mortality or remission rate.
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Aroca Martínez A, Pérez Jiménez V, Raad Sarabia M, Perea Rojas D, Guido Musso C, Depine S, et al. Sociodemographic, clinical, and laboratory profile of patients with early-onset versus late-onset systemic lupus erythematosus. A single-center observational study in the Colombian Caribbean. REV SEN 2025; 14(1):1-9. DOI: http://doi.org/10.56867/156
