IgA nephropathy associated with superimposed acute kidney injury. A report of an unusual case
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.contributor.author | Restrepo, Carlos M. | |
| dc.contributor.author | Villavicencio Ceron, Vanessa | |
| dc.contributor.author | daza arnedo, rodrigo andres | |
| dc.contributor.author | Rico-Fontalvo, Jorge | |
| dc.contributor.author | De Rosa, Marcelo | |
| dc.contributor.author | Remache-Otanez, Verónica P. | |
| dc.date.accessioned | 2026-04-09T19:46:10Z | |
| dc.date.available | 2026-04-09T19:46:10Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | IgA nephropathy is the most common glomerulopathy, characterized by immune complex deposits in the glomeruli causing renal damage. It is associated with genetic predisposition and abnormal immune responses. We present the case of a 15-year-old adolescent with glomerular hematuria and acute renal deterioration following a viral illness and exposure toNSAIDs and iodinated contrast. Renal biopsy revealed IgA nephropathy and acute tubulointerstitial nephritis (ATIN) witheosinophilia. She received methylprednisolone pulses, achieving renal recovery. This case highlights the importance of distinguishing acute complications in patients with IgA nephropathy to ensure timely and appropriate management. IgA nephropathy and interstitial nephritis are connected through inflammatory mechanisms in the kidney. Although IgA nephropathyprimarily affects the glomeruli with different histologic patterns, in this case we found interstitial inflammation exacerbatingdamage and accelerating the deterioration of renal function. This highlights the importance of addressing all the mechanismof acute kidney injury to prevent progression to end-stage renal disease. | eng |
| dc.description.abstract | La nefropatía por IgA es la glomerulopatía más común, caracterizada por depósitos de complejos inmunes en los glomérulos que causan daño renal. Se asocia con predisposición genética y respuestas inmunológicas anormales. Se presenta el caso de una adolescente de 15 años con hematuria glomerular y deterioro renal agudo tras un cuadro viral y exposición a AINEs y contraste iodado. La biopsia reveló nefropatía por IgA y nefritis túbulo-intersticial aguda (NTIA) con eosinofilia. Recibió pulsos de metilprednisolona, logrando recuperación renal. Este caso subraya la importancia de diferenciar complicaciones agudas en pacientes con nefropatía por IgA para un manejo oportuno. La nefropatía por IgA y la NTIA están interconectadas a través de mecanismos inflamatorios a nivel renal. Aunque la nefropatía por IgA afecta principalmente a los glomérulos con diferentes patrones histológicos, en este caso encontramos una inflamación intersticial aguda y severa que exacerba el daño y acelera el deterioro de la función renal. Esto pone de manifiesto la importancia de abordar todos los mecanismos de la lesión renal aguda para prevenir la progresión a la enfermedad renal crónica avanzada. | spa |
| dc.format.mimetype | ||
| dc.identifier.citation | Restrepo CM, et al. IgA nephropathy associated with superimposed acute kidney injury. A report of an unusual case. Nefro Latinoam. 2026;23(X):1-6. doi: 10.24875/NEFRO.24000032 | eng |
| dc.identifier.doi | http://dx.doi.org/10.24875/NEFRO.24000032 | |
| dc.identifier.issn | 24449032 (electrónico) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/17516 | |
| dc.identifier.url | https://www.nefrologialatinoamericana.com/files/es/nefro_032_24_iga.pdf | |
| dc.language.iso | eng | |
| dc.publisher | Sociedad Latinoamericana de Nefrología e Hipertensión | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Nefrología Latinoamericana | spa |
| dc.source | Nefro Latinoam. | eng |
| dc.source | Vol. 23 No. Año 2026 | spa |
| dc.subject | Nefropatía por IgA | spa |
| dc.subject | Nefritis túbulo intersticial | spa |
| dc.subject | Biopsia renal | spa |
| dc.subject | Hematuria | spa |
| dc.subject.keywords | IgA nephropathy | eng |
| dc.subject.keywords | Tubulointerstitial nephritis | eng |
| dc.subject.keywords | Renal biopsy | eng |
| dc.subject.keywords | Hematuria | eng |
| dc.title | IgA nephropathy associated with superimposed acute kidney injury. A report of an unusual case | eng |
| dc.title.translated | Nefropatía por IgA asociada a Lesión renal aguda por sobreposición. A propósito de un caso inusual | spa |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.spa | Artículo científico | |
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| oaire.version | info:eu-repo/semantics/publishedVersion | |
| sb.sede | Sede Barranquilla | spa |