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Evaluation of Tacrolimus Combined With Corticosteroids vs Modified Ponticelli Regimen as Treatments for Refractory Primary Membranous Nephropathy

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dc.contributor.authorNavarro-Quiroz, Elkin
dc.contributor.authorAroca-Martinez, Gustavo
dc.contributor.authorDomínguez-Vargas, Alex
dc.contributor.authorAlonso-López, María José
dc.contributor.authorAlvarado-Echeverría, Rebeca
dc.contributor.authorNavarro-Quiroz, Roberto
dc.contributor.authorSilva-Díaz, Diana
dc.contributor.authorGomez Escorcia, Lorena
dc.contributor.authorGonzález-Tórres, Henry J.
dc.date.accessioned2018-11-09T22:50:19Z
dc.date.available2018-11-09T22:50:19Z
dc.date.issued2018-11
dc.description.abstractObjective: To evaluate the immunosuppressive treatment response to modified Ponticelli regimen (MPR) and oral corticosteroid (OC) plus tacrolimus (TAC) in patients with primary membranous nephropathy (PMN). Methods: Retrospective cohort analytical study. Adults patients (>18 years old) with diagnosis of refractory PMN (>50% increase in serum creatinine or a level >1.5mg/dl or proteinuria refractory to 6 months of supportive treatment), proved by renal biopsy and immunofluorescence between 2008 and 2016 from the Nephropathy Registry of Colombia (NEFRORED©) were included. Immunosuppressive treatment response was evaluated from baseline to 6 months after the start of therapy. Results: 128 patients with PMN were included, of which 74 (57%) were female. The most frequent syndromic diagnosis was nephrotic syndrome 90 (70%), followed by asymptomatic urinary disorders 31 (25%). Chronic kidney disease manifested concomitantly in 7 (5%) patients. At the end of 6 months, 86 (67%) cases achieved some degree of remission: 23 (18%) complete response (CR) and 63 (49%) cases with partial response (PR), while 42 (33%) cases did not achieved remission. In the TAC+OC group, CR and PR were seen in 14 (20%) and 33 (47%) patients, respectively; and 9 (16%) and 30 (51%) patients in the MPR group, respectively. No statistically significant differences were found when comparing the immunosuppressive treatment response rate with both treatment groups (p > 0.05). Conclusions: In the PMN, both immunosuppressive treatments (TAC+OC vs MPR) are comparable. We suggest a clinical follow-up of the anti-PLA2R/THSD7A titres at 6/12 months to be correlated with renal function in subsequent studies.eng
dc.identifier.issn19169744
dc.identifier.urihttp://hdl.handle.net/20.500.12442/2346
dc.language.isoengeng
dc.publisherCanadian Center of Science and Educationeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseLicencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalspa
dc.sourceGlobal Journal of Health Scienceeng
dc.sourceVol. 10, No. 12 (2018)spa
dc.source.urihttps://doi.org/10.5539/gjhs.v10n12p63eng
dc.subjectPrimary membranous nephropathyeng
dc.subjectModified Ponticelli regimeneng
dc.subjectImmunosuppressive therapyeng
dc.subjectTacrolimuseng
dc.titleEvaluation of Tacrolimus Combined With Corticosteroids vs Modified Ponticelli Regimen as Treatments for Refractory Primary Membranous Nephropathyeng
dc.typearticleeng
dcterms.referencesAldana, I., Diazgranados, I., Aroca, G., & García, R. (2014). Respuesta al esquema Ponticelli en pacientes con nefropatía membranosa idiopática. Barranquilla 2011-2013. Biociencias, 9(1), 23-29.spa
dcterms.referencesAroca-Martínez, G., Depine, S., Consuegra-Machado, J. R., González-Torres, H. J., Árquez-Mendoza, M., & Estrada-García, E. (2015). Development and use of an application programming interface modified from GoogleMaps© for the georeferencing of patients with glomerular disease. Nefrología : Publicación Oficial de La Sociedad Española Nefrologia, 35(1), 118-120. https://doi.org/10.3265/Nefrologia.pre2014.Oct.12736eng
dcterms.referencesCattran, D., & Brenchley, P. (2017). Membranous nephropathy: thinking through the therapeutic options. Nephrology Dialysis Transplantation, 32(suppl_1), i22-i29. https://doi.org/10.1093/ndt/gfw404eng
dcterms.referencesCattran, D. C., & Brenchley, P. E. (2017a). Membranous nephropathy: integrating basic science into improved clinical management. Kidney International, 91(3), 566-574. https://doi.org/10.1016/j.kint.2016.09.048eng
dcterms.referencesChen, M., Wang, H.-Y., Li, H., Li, X.-W., Li, X.-Y., Chen, J.-H., … Xu, F.-F. (2010). Tacrolimus Combined With Corticosteroids in Treatment of Nephrotic Idiopathic Membranous Nephropathy: A Multicenter Randomized Controlled Trial. The American Journal of the Medical Sciences, 339(3), 233-238. https://doi.org/10.1097/MAJ.0b013e3181ca3a7deng
dcterms.referencesCouser, W. G. (2017). Primary membranous nephropathy. Clinical Journal of the American Society of Nephrology, 12(6), 983-997. https://doi.org/10.2215/CJN.11761116eng
dcterms.referencesDas, U., Dakshinamurty, K., & Prasad, N. (2009). Ponticelli regimen in idiopathic nephrotic syndrome. Indian Journal of Nephrology, 19(2), 48. https://doi.org/10.4103/0971-4065.53321eng
dcterms.referencesDe Vriese, A. S., Glassock, R. J., Nath, K. A., Sethi, S., & Fervenza, F. C. (2017). A Proposal for a Serology-Based Approach to Membranous Nephropathy. Journal of the American Society of Nephrology, 28(2), 421-430. https://doi.org/10.1681/ASN.2016070776eng
dcterms.referencesFervenza, F. C., Canetta, P. A., Barbour, S. J., Lafayette, R. A., Rovin, B. H., Aslam, N., … Cattran, D. C. (2015). A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR). Nephron, 130(3), 159-168. https://doi.org/10.1159/000430849eng
dcterms.referencesFrancis, J. M., Beck, L. H., & Salant, D. J. (2016). Membranous Nephropathy: A Journey From Bench to Bedside. American Journal of Kidney Diseases, 68(1), 138-147. https://doi.org/10.1053/j.ajkd.2016.01.030eng
dcterms.referencesGaviria-García, G., Turizo, L., Orostegui, M., Suárez-Villa, M., Rivera-Julio, Y., Villalba, A., … Navarro-Díaz, L. (2015). Evaluacion del aprendizaje en enfermería: una mirada desde la asignatura del area profesional. In Educación: Una Mirada Desde La Comunicación, La Tecnología, La Investigación Y La Didactica (pp. 145-147). Colombia,: ed: Corporación Universitaria Americana.spa
dcterms.referencesHe, L., Peng, Y., Liu, H., Liu, Y., Yuan, S., Liu, F., … Fu, M. (2013). Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids. Journal of Nephrology, 26(3), 564-571. https://doi.org/10.5301/jn.5000199eng
dcterms.referencesLai, W. L., Yeh, T. H., Chen, P. M., Chan, C. K., Chiang, W. C., Chen, Y. M., … Tsai, T. J. (2015). Membranous nephropathy: A review on the pathogenesis, diagnosis, and treatment. Journal of the Formosan Medical Association, 114(2), 102-111. https://doi.org/10.1016/j.jfma.2014.11.002eng
dcterms.referencesMa, H., Sandor, D. G., & Beck, L. H. (2013). The Role of Complement in Membranous Nephropathy. Seminars in Nephrology, 33(6), 531-542. https://doi.org/10.1016/j.semnephrol.2013.08.004eng
dcterms.referencesPonticelli, C., Altieri, P., Scolari, F., Passerini, P., Roccatello, D., Cesana, B., … Bellazzi, R. (1998). A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. Journal of the American Society of Nephrology : JASN, 9(3), 444-450. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9513907eng
dcterms.referencesPonticelli, C., & Glassock, R. J. (2014). Glomerular Diseases: Membranous Nephropathy--A Modern View. Clinical Journal of the American Society of Nephrology, 9(3), 609-616. https://doi.org/10.2215/CJN.04160413eng
dcterms.referencesR Core Team. (2015). R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.eng
dcterms.referencesRamachandran, R., Hn, H. K., Kumar, V., Nada, R., Yadav, A. K., Goyal, A., … Kohli, H. S. (2016). Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial. Nephrology, 21(2), 139-146. https://doi.org/10.1111/nep.12569eng
dcterms.referencesRonco, P., & Debiec, H. (2010). Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy. Journal of the American Society of Nephrology : JASN, 21(4), 564-569. https://doi.org/10.1681/ASN.2009121220eng
dcterms.referencesSierra, C. (2017). Calidad de vida en pacientes con enfermedad renal crónica de una institución de salud. In Estudios actuales en Psicología . Perspectivas en Clinica y Salud (pp. 71-93. ISBN: 978-958-8930-68–8). Colombia: ed: Editorial Mejoras.spa
dcterms.referencesThompson, A., Cattran, D. C., Blank, M., & Nachman, P. H. (2015). Complete and Partial Remission as Surrogate End Points in Membranous Nephropathy. Journal of the American Society of Nephrology, 26(12), 2930-2937. https://doi.org/10.1681/ASN.2015010091eng
dcterms.referencesTomas, N. M., Beck, L. H., Meyer-Schwesinger, C., Seitz-Polski, B., Ma, H., Zahner, G., … Lambeau, G. (2014). Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy. New England Journal of Medicine, 371(24), 2277-2287. https://doi.org/10.1056/NEJMoa1409354eng

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