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Caracterización clínica y epidemiológica de las hemorragias de vías digestivas altas en pacientes sin infección por HELICOBACTER pylori en una clínica de cuarto nivel en Barranquilla (ATL, CO) 2021–2023

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datacite.rightshttp://purl.org/coar/access_right/c_16ec
dc.contributor.advisorBrochado Fontalvo, Leonardo
dc.contributor.advisorGonzález Torres, Henry Joseth
dc.contributor.authorJurado Delgado, Gregorio
dc.contributor.authorPadilla Gutiérrez, Giselle María
dc.date.accessioned2026-01-29T20:21:11Z
dc.date.available2026-01-29T20:21:11Z
dc.date.issued2025
dc.description.abstractIntroducción: La hemorragia de vías digestivas altas (HVDA) continúa siendo una causa frecuente de hospitalización y mortalidad. Aunque la infección por Helicobacter pylori ha sido históricamente la principal etiología, su disminución ha modificado el perfil clínico de los pacientes, haciendo necesario estudiar a quienes presentan HVDA sin dicha infección. Objetivo: Caracterizar el perfil clínico, comorbilidades, diagnóstico de ingreso, duración de la estancia hospitalaria y factores asociados con la mortalidad en pacientes con HVDA sin infección por H. pylori. Metodología: Estudio observacional, retrospectivo y analítico realizado en una clínica de cuarto nivel en Barranquilla (Colombia), entre 2021 y 2023. Se incluyeron 285 pacientes ≥18 años con diagnóstico endoscópico de HVDA y pruebas negativas para H. pylori. Se analizaron variables clínicas, paraclínicas y de desenlace mediante estadística descriptiva, bivariada y multivariada. Resultados: La mediana de edad fue 60 años, con predominio de hipertensión arterial (42%) y diabetes tipo 2 (17%). La hematemesis fue el diagnóstico de ingreso más frecuente (53%). Pacientes con melena fueron significativamente mayores y presentaron más úlceras gástricas. La estancia hospitalaria fue mayor en pacientes mayores de 60 años (p<0.001). La mortalidad fue del 5%, asociada con edad avanzada (OR: 3.14), complicaciones cardiovasculares (OR: 12.1) y encefalopatía secundario a hepatopatía avanzada o hipóxica (OR: 9.0). Conclusión: La HVDA sin H. pylori afecta principalmente a adultos mayores con comorbilidades relevantes. La forma de presentación y las complicaciones sistémicas son determinantes clave del pronóstico, lo que exige un enfoque clínico diferencial y oportuno.spa
dc.description.abstractBackground: Upper gastrointestinal bleeding (UGIB) remains a major cause of hospitalization and mortality. Although Helicobacter pylori infection has traditionally been its main etiology, its decreasing prevalence has changed the clinical profile of affected patients, highlighting the need to study UGIB cases without this infection. Objective: To characterize the clinical profile, comorbidities, admission diagnosis, hospital stay duration, and mortality-associated factors in patients with UGIB without H. pylori infection. Methods: A retrospective, observational, analytical study was conducted in a tertiary care center in Barranquilla (Colombia) from 2021 to 2023. We included 285 patients aged ≥18 years with endoscopically confirmed UGIB and negative H. pylori tests. Clinical, paraclinical, and outcome variables were analyzed using descriptive, bivariate, and multivariate statistics. Results: Median age was 60 years, with hypertension (42%) and type 2 diabetes (17%) as the most common comorbidities. Hematemesis was the most frequent admission diagnosis (53%). Patients with melena were significantly older and had more gastric ulcers. Hospital stay was longer among patients over 60 years (p<0.001). Overall mortality was 5%, associated with older age (OR: 3.14), cardiovascular complications (OR: 12.1), and encephalopathy secondary to advanced hepatopathy or hypoxic etiology (OR: 9.0). Conclusion: UGIB without H. pylori mainly affects older adults with significant comorbidities. Presentation type and systemic complications are key prognostic factors, requiring timely and tailored clinical approaches.eng
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/20.500.12442/17315
dc.language.isospa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad Ciencias de la Saludspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHemorragia digestiva altaspa
dc.subjectHelicobacter pylorispa
dc.subjectMortalidad hospitalariaspa
dc.subjectComorbilidadesspa
dc.subjectMelenaspa
dc.subjectHematemesisspa
dc.subject.keywordsUpper gastrointestinal bleedingeng
dc.subject.keywordsHelicobacter pylorieng
dc.subject.keywordsHospital mortalityeng
dc.subject.keywordsComorbiditieseng
dc.subject.keywordsMelenaeng
dc.subject.keywordsHematemesiseng
dc.titleCaracterización clínica y epidemiológica de las hemorragias de vías digestivas altas en pacientes sin infección por HELICOBACTER pylori en una clínica de cuarto nivel en Barranquilla (ATL, CO) 2021–2023spa
dc.type.driverinfo:eu-repo/semantics/other
dc.type.spaOtros
dcterms.referencesBarkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 2010;152:101–13. https://doi.org/10.7326/0003-4819-152-2-201001190- 00009.eng
dcterms.referencesGoh K-L, Chan W-K, Shiota S, Yamaoka Y. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter 2011;16 Suppl 1:1–9. https://doi.org/10.1111/j.1523-5378.2011.00874.x.eng
dcterms.referencesLau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 2000;343:310–6. https://doi.org/10.1056/NEJM200008033430501.eng
dcterms.referencesLanas A, Chan FKL. Peptic ulcer disease. Lancet (London, England) 2017;390:613–24. https://doi.org/10.1016/S0140-6736(16)32404-7.eng
dcterms.referencesSostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther 2013;15 Suppl 3:S3. https://doi.org/10.1186/ar4175.eng
dcterms.referencesKamboj AK, Hoversten P, Leggett CL. Upper Gastrointestinal Bleeding: Etiologies and Management. Mayo Clin Proc 2019;94:697–703. https://doi.org/10.1016/j.mayocp.2019.01.022.eng
dcterms.referencesGonzález-González JA, García-Compean D, Vázquez-Elizondo G, Garza- Galindo A, Jáquez-Quintana JO, Maldonado-Garza H. Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol 2011;10:287–95. https://doi.org/10.1016/S1665-2681(19)31540-6.eng
dcterms.referencesElfert K, Love J, Elromisy E, Jaber F, Nayudu S, Ho S, et al. Clinical outcomes of nonvariceal upper gastrointestinal bleeding in nonagenarians and octogenarians: a comparative nationwide analysis. Clin Endosc 2024;57:342– 9. https://doi.org/10.5946/ce.2023.130.eng
dcterms.referencesTielleman T, Bujanda D, Cryer B. Epidemiology and Risk Factors for Upper Gastrointestinal Bleeding. Gastrointest Endosc Clin N Am 2015;25:415–28. https://doi.org/10.1016/j.giec.2015.02.010.eng
dcterms.referencesLoperfido S, Baldo V, Piovesana E, Bellina L, Rossi K, Groppo M, et al. Changing trends in acute upper-GI bleeding: a population-based study. Gastrointest Endosc 2009;70:212–24. https://doi.org/10.1016/j.gie.2008.10.051.eng
dcterms.referencesGado AS, Ebeid BA, Abdelmohsen AM, Axon AT. Clinical outcome of acute upper gastrointestinal hemorrhage among patients admitted to a government hospital in Egypt. Saudi J Gastroenterol 2012;18:34–9. https://doi.org/10.4103/1319-3767.91737.eng
dcterms.referencesAbougergi MS, Travis AC, Saltzman JR. The in-hospital mortality rate for upper GI hemorrhage has decreased over 2 decades in the United States: a nationwide analysis. Gastrointest Endosc 2015;81:882-8.e1. https://doi.org/10.1016/j.gie.2014.09.027.eng
dcterms.referencesRockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut 1996;38:316–21. https://doi.org/10.1136/gut.38.3.316.eng
dcterms.referencesBlatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet (London, England) 2000;356:1318–21. https://doi.org/10.1016/S0140-6736(00)02816-6.eng
dcterms.referencesStanley AJ. Update on risk scoring systems for patients with upper gastrointestinal haemorrhage. World J Gastroenterol 2012;18:2739–44. https://doi.org/10.3748/wjg.v18.i22.2739.eng
dcterms.referencesHearnshaw SA, Logan RFA, Lowe D, Travis SPL, Murphy MF, Palmer KR. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut 2011;60:1327–35. https://doi.org/10.1136/gut.2010.228437.eng
dcterms.referencesDiGregorio AM, Alvey H. Gastrointestinal Bleeding. n.d.eng
dcterms.referencesMalfertheiner P, Megraud F, O’Morain CA, Gisbert JP, Kuipers EJ, Axon AT, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 2017;66:6–30. https://doi.org/10.1136/gutjnl-2016- 312288.eng
dcterms.referencesSung JJY, Kuipers EJ, El-Serag HB. Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther 2009;29:938– 46. https://doi.org/10.1111/j.1365-2036.2009.03960.x.eng
dcterms.referencesAbraham NS, Hartman C, Richardson P, Castillo D, Street RL, Naik AD. Risk of lower and upper gastrointestinal bleeding, transfusions, and hospitalizations with complex antithrombotic therapy in elderly patients. Circulation 2013;128:1869–77. https://doi.org/10.1161/CIRCULATIONAHA.113.004747.eng
dcterms.referencesSekhar Goud EVS, Kannan R, Rao UK, Joshua E, Tavaraja R, Jain Y. Identification of Helicobacter pylori in Saliva of Patients with and without Gastritis by Polymerase Chain Reaction. J Pharm Bioallied Sci 2019;11:S523– 9. https://doi.org/10.4103/jpbs.JPBS_260_18.eng
dcterms.referencesKim BSM. Diagnosis of gastrointestinal bleeding: A practical guide for clinicians. World J Gastrointest Pathophysiol 2014;5:467. https://doi.org/10.4291/wjgp.v5.i4.467.eng
dcterms.referencesStanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. BMJ 2019;364:l536. https://doi.org/10.1136/bmj.l536.eng
dcterms.referencesHearnshaw SA, Logan RFA, Palmer KR, Card TR, Travis SPL, Murphy MF. Outcomes following early red blood cell transfusion in acute upper gastrointestinal bleeding. Aliment Pharmacol Ther 2010;32:215–24. https://doi.org/10.1111/j.1365-2036.2010.04348.x.eng
dcterms.referencesLaursen SB, Dalton HR, Murray IA, Michell N, Johnston MR, Schultz M, et al. Performance of new thresholds of the Glasgow Blatchford score in managing patients with upper gastrointestinal bleeding. Clin Gastroenterol Hepatol 2015;13:115-21.e2. https://doi.org/10.1016/j.cgh.2014.07.023.eng
dcterms.referencesGarcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med 2010;362:823–32. https://doi.org/10.1056/NEJMra0901512.eng
dcterms.referencesWilson ID. Hematemesis, Melena, and Hematochezia. 1990.eng
dcterms.referencesLaursen SB, Hansen JM, Schaffalitzky de Muckadell OB. The Glasgow Blatchford Score Is the Most Accurate Assessment of Patients With Upper Gastrointestinal Hemorrhage. Clin Gastroenterol Hepatol 2012;10:1130- 1135.e1. https://doi.org/10.1016/j.cgh.2012.06.022.eng
dcterms.referencesAntunes C, Tian C, Copelin II EL. Upper Gastrointestinal Bleeding. 2025.eng
dcterms.referencesRodriguez-Morales AJ, Paniz-Mondolfi AE, Faccini-Martínez ÁA, Henao- Martínez AF, Ruiz-Saenz J, Martinez-Gutierrez M, et al. The Constant Threat of Zoonotic and Vector-Borne Emerging Tropical Diseases: Living on the Edge. Front Trop Dis 2021;2:676905. https://doi.org/10.3389/fitd.2021.676905.eng
dcterms.referencesLanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Alonso-Abreu I, Perez-Aisa MA, et al. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol 2009;104:1633–41. https://doi.org/10.1038/ajg.2009.164.eng
dcterms.referencesBarkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, et al. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. Ann Intern Med 2019;171:805–22. https://doi.org/10.7326/M19-1795.eng
dcterms.referencesHearnshaw SA, Logan RFA, Lowe D, Travis SPL, Murphy MF, Palmer KR. Use of endoscopy for management of acute upper gastrointestinal bleeding in the UK: results of a nationwide audit. Gut 2010;59:1022–9. https://doi.org/10.1136/gut.2008.174599.eng
dcterms.referencesStanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, et al. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. BMJ 2017;356:i6432. https://doi.org/10.1136/bmj.i6432.eng
dcterms.referencesLau JYW, Yu Y, Tang RSY, Chan HCH, Yip H-C, Chan SM, et al. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2020;382:1299–308. https://doi.org/10.1056/NEJMoa1912484.eng
dcterms.referencesPorras JLM, Panero JLC. Hemorragia digestiva alta: etiología y procedimientos diagnósticos. Emergencias Rev La Soc Española Med Urgencias y Emergencias, ISSN 1137-6821, Vol 17, No 2, 2005, Págs 52-61 2016:50–4.spa
dcterms.referencesMalfertheiner P, Megraud F, Rokkas T, Gisbert JP, Liou J-M, Schulz C, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut 2022;71:1724–62. https://doi.org/10.1136/gutjnl-2022- 327745.eng
dcterms.referencesLanas Á, Carrera-Lasfuentes P, Arguedas Y, García S, Bujanda L, Calvet X, et al. Risk of Upper and Lower Gastrointestinal Bleeding in Patients Taking Nonsteroidal Anti-inflammatory Drugs, Antiplatelet Agents, or Anticoagulants. Clin Gastroenterol Hepatol 2015;13:906-912.e2. https://doi.org/10.1016/j.cgh.2014.11.007.eng
dcterms.referencesOrpen-Palmer J, Stanley AJ. Update on the management of upper gastrointestinal bleeding. BMJ Med 2022;1:e000202. https://doi.org/10.1136/bmjmed-2022-000202.eng
dcterms.referencesXie X, Ren K, Zhou Z, Dang C, Zhang H. The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study. BMC Gastroenterol 2022;22:58. https://doi.org/10.1186/s12876-022-02130-2.eng
dcterms.referencesSung JJ, Chiu PW, Chan FKL, Lau JY, Goh K-L, Ho LH, et al. Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018. Gut 2018;67:1757–68. https://doi.org/10.1136/gutjnl-2018- 316276.eng
dcterms.referencesGarcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology 2017;65:310–35. https://doi.org/10.1002/hep.28906.eng
dcterms.referencesRandall GM, Jensen DM. Diagnosis and Management of Bleeding from Upper Gastrointestinal Neoplasms. Gastrointest Endosc Clin N Am 1991;1:401–27. https://doi.org/10.1016/S1052-5157(18)30678-0.eng
dcterms.referencesAbraham NS, Noseworthy PA, Yao X, Sangaralingham LR, Shah ND. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population- Based Study. Gastroenterology 2017;152:1014-1022.e1. https://doi.org/10.1053/j.gastro.2016.12.018.eng
dcterms.referencesGutermann IK, Niggemeier V, Zimmerli LU, Holzer BM, Battegay E, Scharl M. Gastrointestinal bleeding and anticoagulant or antiplatelet drugs: systematic search for clinical practice guidelines. Medicine (Baltimore) 2015;94:e377. https://doi.org/10.1097/MD.0000000000000377.eng
dcterms.referencesSørensen R, Hansen ML, Abildstrom SZ, Hvelplund A, Andersson C, Jørgensen C, et al. Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data. Lancet 2009;374:1967–74. https://doi.org/10.1016/S0140-6736(09)61751-7.eng
dcterms.referencesWilcox CM, Cryer BL, Henk HJ, Zarotsky V, Zlateva G. Mortality associated with gastrointestinal bleeding events: Comparing short-term clinical outcomes of patients hospitalized for upper GI bleeding and acute myocardial infarction in a US managed care setting. Clin Exp Gastroenterol 2009;2:21–30. https://doi.org/10.2147/ceg.s4936.eng
dcterms.referencesLanas A, Perez-Aisa MA, Feu F, Ponce J, Saperas E, Santolaria S, et al. A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. Am J Gastroenterol 2005;100:1685–93. https://doi.org/10.1111/j.1572-0241.2005.41833.x.eng
dcterms.referencesLaine L, Jensen DM. Management of Patients With Ulcer Bleeding. Am J Gastroenterol 2012;107:345–60. https://doi.org/10.1038/ajg.2011.480eng
dcterms.referencesPongprasobchai S, Nimitvilai S, Chasawat J, Klanatsathit S. Upper gastrointestinal bleeding etiology score for predicting variceal and non-variceal bleeding. World J Gastroenterol 2009;15:1099–104. https://doi.org/10.3748/wjg.15.1099.eng
dcterms.referencesSaltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointest Endosc 2011;74:1215–24. https://doi.org/10.1016/j.gie.2011.06.024.eng
dcterms.referencesLu M, Sun G, Huang H, Zhang X, Xu Y, Chen S, et al. Comparison of the Glasgow-Blatchford and Rockall Scores for prediction of nonvariceal upper gastrointestinal bleeding outcomes in Chinese patients. Medicine (Baltimore) 2019;98:e15716. https://doi.org/10.1097/MD.0000000000015716.eng
dcterms.referencesFrías-Ordoñez JS, Arjona-Granados DA, Urrego-Díaz JA, Briceño-Torres M, Martínez-Marín JD. VALIDATION OF THE ROCKALL SCORE IN UPPER GASTROINTESTINAL TRACT BLEEDING IN A COLOMBIAN TERTIARY HOSPITAL. Arq Gastroenterol 2022;59:80–8. https://doi.org/10.1590/S0004- 2803.202200001-15.eng
dcterms.referencesRobertson M, Majumdar A, Boyapati R, Chung W, Worland T, Terbah R, et al. Risk stratification in acute upper GI bleeding: comparison of the AIMS65 score with the Glasgow-Blatchford and Rockall scoring systems. Gastrointest Endosc 2016;83:1151–60. https://doi.org/10.1016/j.gie.2015.10.021.eng
dcterms.referencesHyett BH, Abougergi MS, Charpentier JP, Kumar NL, Brozovic S, Claggett BL, et al. The AIMS65 score compared with the Glasgow-Blatchford score in predicting outcomes in upper GI bleeding. Gastrointest Endosc 2013;77:551– 7. https://doi.org/10.1016/j.gie.2012.11.022.eng
dcterms.referencesBryant R V, Kuo P, Williamson K, Yam C, Schoeman MN, Holloway RH, et al. Performance of the Glasgow-Blatchford score in predicting clinical outcomes and intervention in hospitalized patients with upper GI bleeding. Gastrointest Endosc 2013;78:576–83. https://doi.org/10.1016/j.gie.2013.05.003.eng
dcterms.referencesCheng DW, Lu YW, Teller T, Sekhon HK, Wu BU. A modified Glasgow Blatchford Score improves risk stratification in upper gastrointestinal bleed: a prospective comparison of scoring systems. Aliment Pharmacol Ther 2012;36:782–9. https://doi.org/10.1111/apt.12029.eng
dcterms.referencesLee YJ, Min BR, Kim ES, Park KS, Cho KB, Jang BK, et al. Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding. Korean J Intern Med 2015;31:54–64. https://doi.org/10.3904/kjim.2016.31.1.54.eng
dcterms.referencesJairath V, Barkun AN. The overall approach to the management of upper gastrointestinal bleeding. Gastrointest Endosc Clin N Am 2011;21:657–70. https://doi.org/10.1016/j.giec.2011.07.001.eng
dcterms.referencesWeissman S, Aziz M, Bangolo AI, Ehrlich D, Forlemu A, Willie A, et al. Relationships of hospitalization outcomes and timing to endoscopy in non- variceal upper gastrointestinal bleeding: A nationwide analysis. World J Gastrointest Endosc 2023;15:285–96. https://doi.org/10.4253/wjge.v15.i4.285.eng
dcterms.referencesLee JH, Kim BK, Seol DC, Byun SJ, Park KH, Sung IK, et al. Rescue endoscopic bleeding control for nonvariceal upper gastrointestinal hemorrhage using clipping and detachable snaring. Endoscopy 2013;45:489– 92. https://doi.org/10.1055/s-0032-1326375.eng
dcterms.referencesMiilunpohja S, Kärkkäinen J, Hartikainen J, Jyrkkä J, Rantanen T, Paajanen H. Need of Emergency Surgery in Elderly Patients with Upper Gastrointestinal Bleeding: Survival Analysis during 2009–2015. Dig Surg 2019;36:20–6. https://doi.org/10.1159/000485846.eng
dcterms.referencesHur S, Jae HJ, Lee H, Lee M, Kim H-C, Chung JW. Superselective Embolization for Arterial Upper Gastrointestinal Bleeding Using <em>N</em>- Butyl Cyanoacrylate: A Single-Center Experience in 152 Patients. J Vasc Interv Radiol 2017;28:1673–80. https://doi.org/10.1016/j.jvir.2017.07.027.eng
dcterms.referencesVillanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, et al. Transfusion Strategies for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2013;368:11–21. https://doi.org/10.1056/NEJMoa1211801.eng
dcterms.referencesTaghavi S, Nassar A k., Askari R. Hypovolemic Shock. 2023.eng
dcterms.referencesRivera H D, Martínez M JD, Tovar C JR, Garzón O MA, Hormaza A N, Lizarazo JI, et al. Original articles Characterization of patients with non-varicose upper GI bleeding at a Level. Rev Colomb Gastroenterol 2013;28:278–85.eng
dcterms.referencesFORGERINI M, URBANO G, NADAI TR de, ZAPATA-CACHAFEIRO M, KEMP R, MASTROIANNI P de C. EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING SECONDARY TO PEPTIC DISEASE IN A TERTIARY REFERRAL BRAZILIAN HOSPITAL. Arq Gastroenterol 2021;58:202–9. https://doi.org/10.1590/s0004-2803.202100000-36.eng
dcterms.referencesLee YY, Noridah N, Syed Hassan SAA, Menon J. Absence of Helicobacter pylori is not protective against peptic ulcer bleeding in elderly on offending agents: lessons from an exceptionally low prevalence population. PeerJ 2014;2:e257. https://doi.org/10.7717/peerj.257.eng
dcterms.referencesRaj A, Kaeley N, Prasad H, Patnaik I, Bahurupi Y, Joshi S, et al. Prospective observational study on clinical and epidemiological profile of adult patients presenting to the emergency department with suspected upper gastrointestinal bleed. BMC Emerg Med 2023;23:107. https://doi.org/10.1186/s12873-023-00885-9.eng
dcterms.referencesAkhtar MZ, Huq MU, Adwani R, Usman A, Ijaz S, Seher I. Utilizing Endoscopy for the Diagnosis of Acute Upper Gastrointestinal Bleeding. Cureus 2023;15:e40994. https://doi.org/10.7759/cureus.40994.eng
dcterms.referencesDurak MB, Şimşek C, Yüksel İ. Clinical Outcomes of Older Patients with Non- Variceal Upper Gastrointestinal Bleeding Taking Anti-Thrombotic or Non- Steroidal Anti-Inflammatory Agents. Turk J Gastroenterol 2023;34:918–24. https://doi.org/10.5152/tjg.2023.23226.eng
dcterms.referencesMoledina SM, Komba E. Risk factors for mortality among patients admitted with upper gastrointestinal bleeding at a tertiary hospital: a prospective cohort study. BMC Gastroenterol 2017;17:165. https://doi.org/10.1186/s12876-017- 0712-8.eng
dcterms.referencesMoomal Bhutto, Prem Kumar, Nadeem Bajkani, Shabana Lakho, Chaman Das, Dolat Singh. Magnitude of Diabetes Mellitus in Upper Gastrointestinal Hemorrhage. Ann PIMS-Shaheed Zulfiqar Ali Bhutto Med Univ 2024;19:481– 5. https://doi.org/10.48036/apims.v13i4.1003.eng
dcterms.referencesScarpignato C, Lanas A, Blandizzi C, Lems WF, Hermann M, Hunt RH. Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks. BMC Med 2015;13:55. https://doi.org/10.1186/s12916-015-0285-8.eng
dcterms.referencesBosch J, Abraldes J, Berzigotti A, Garcia-Pagan J. Portal Hypertension and Gastrointestinal Bleeding. Semin Liver Dis 2008;28:003–25. https://doi.org/10.1055/s-2008-1040318.eng
dcterms.referencesBazzoli F, De Luca L, Graham DY. Helicobacter pylori infection and the use of NSAIDs. Best Pract Res Clin Gastroenterol 2001;15:775–85. https://doi.org/10.1053/bega.2001.0234.eng
dcterms.referencesLau JYW, Sung JJY, Lee KKC, Yung M, Wong SKH, Wu JCY, et al. Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers. N Engl J Med 2000;343:310–6. https://doi.org/10.1056/NEJM200008033430501.eng
dcterms.referencesSiau K, Hodson J, Ingram R, Baxter A, Widlak MM, Sharratt C, et al. Time to endoscopy for acute upper gastrointestinal bleeding: Results from a prospective multicentre trainee‐led audit. United Eur Gastroenterol J 2019;7:199–209. https://doi.org/10.1177/2050640618811491.eng
dcterms.referencesGurler M, Aktas G. Etiology of Non-variceal Bleeding of upper Gastrointestinal System: A Brief Review. Br J Med Med Res 2016;11:1–4. https://doi.org/10.9734/BJMMR/2016/21716.eng
dcterms.referencesCrooks CJ, West J, Card TR. Comorbidities Affect Risk of Nonvariceal Upper Gastrointestinal Bleeding. Gastroenterology 2013;144:1384-1393.e2. https://doi.org/10.1053/j.gastro.2013.02.040.eng
dcterms.referencesBiecker E. Gastrointestinal Bleeding in Cirrhotic Patients with Portal Hypertension. ISRN Hepatol 2013;2013:541836. https://doi.org/10.1155/2013/541836.eng
dcterms.referencesGoh K, Chan W, Shiota S, Yamaoka Y. Epidemiology of Helicobacter pylori Infection and Public Health Implications. Helicobacter 2011;16:1–9. https://doi.org/10.1111/j.1523-5378.2011.00874.x.eng
dcterms.referencesGarcia‐Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis. Hepatology 2017;65:310–35. https://doi.org/10.1002/hep.28906.eng
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