Descripción de hallazgos clínicos y paraclínicos de microangiopatías trombóticas en pacientes de la Clínica de la Costa
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Fecha
2016
Autores
Obeso Fernández, Yoleidis
Pérez Arregocés, Eddie
Forero Pérez, Haref
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
INTRODUCCION. Las Microangiopatias Trombóticas tienen como características clínicas
la presencia de anemia hemolítica microangiopática, trombos plaquetarios y
trombocitopenia. Las entidades clínicas más importantes de MA T son: Síndrome
Hemolítico Urémico típico y atípico (SHUa), y la Púrpura Trombocitopénica Trombótica
(PTT). Estas son entidades poco frecuentes a nivel mundial, cabe resaltar que en
Colombia aún no existen datos epidemiológicos de estas.
OBJETIVO. Describir los hallazgos clínicos y paraclínicos de microangiopatía trombótica
en pacientes de la clínica de la costa en el periodo de enero del 2013 a septiembre de
2016.
METODOLOGIA: Estudio retrospectivo descriptivo de serie de casos. Los datos fueron
tomados de los registros de historias clínicas de pacientes que cumplían los criterios de
inclusión.
RESULTADOS: Se describe una serie de 10 pacientes con cuadros de MAT, con edades
de los 3 a los 79 años, el 70% de género femenino, de los cuales el 40% presentaron
SHUa, el 30% PTT y el otro 30% clasificado con otros diagnósticos. El 100% presentaron
compromiso hematológico, el 80% compromiso renal, 50% gastrointestinal y en menor
proporción neurológico y pulmonar. La principales condiciones predisponentes para el
desarrollo de MA T fueron Lupus eritematoso sistémico e Hipertensión arterial. De los
pacientes evaluados dos fallecieron.
INTRODUCTION: Thrombotic microangiopathy has the clinical features as the presence of microangiopathic hemolytic anemia, thrombocytopenia and platelet thrombi. The most important clinical entities MAT are: Syndrome Hemolytic Uremic typical and atypical (aHUS), and thrombotic thrombocytopenic purpura (TTP). These are rare entities worldwide; it is worth noting that in Colombia there are still no epidemiological data of these. OBJECTIVE: To describe the clinical and laboratory findings of thrombotic microangiopathy in patients clinic the coast in the period January 2013 to September 2016. METHODOLOGY. descriptive retrospective case series. The data were collected from medical records of patients who met the inclusion criteria. RESUL TS: A series of 1 O patients with symptoms of MA T, aged 3 to 79 years, 70% were females, 40% of whom had aHUS, 30% PTT and the other 30% is described classified with other diagnoses. 100% had hematologic commitment, 80% renal involvement, 50% gastrointestinal and neurological and pulmonary lesser proportion. The main predisposing conditions for the development of MA T were Systemic Lupus Erythematosus and Hypertension. Of the patients evaluated two died.
INTRODUCTION: Thrombotic microangiopathy has the clinical features as the presence of microangiopathic hemolytic anemia, thrombocytopenia and platelet thrombi. The most important clinical entities MAT are: Syndrome Hemolytic Uremic typical and atypical (aHUS), and thrombotic thrombocytopenic purpura (TTP). These are rare entities worldwide; it is worth noting that in Colombia there are still no epidemiological data of these. OBJECTIVE: To describe the clinical and laboratory findings of thrombotic microangiopathy in patients clinic the coast in the period January 2013 to September 2016. METHODOLOGY. descriptive retrospective case series. The data were collected from medical records of patients who met the inclusion criteria. RESUL TS: A series of 1 O patients with symptoms of MA T, aged 3 to 79 years, 70% were females, 40% of whom had aHUS, 30% PTT and the other 30% is described classified with other diagnoses. 100% had hematologic commitment, 80% renal involvement, 50% gastrointestinal and neurological and pulmonary lesser proportion. The main predisposing conditions for the development of MA T were Systemic Lupus Erythematosus and Hypertension. Of the patients evaluated two died.
Descripción
Palabras clave
Microangiopatias trombóticas, Purpura trombocitopénica trombótica, Síndrome hemolítico agudo atípico, Trombocitopenia, ADAMST 13, Thrombotic microangiopathy, Thrombotic thrombocytopenic purpura, Atypical acute uremic syndrome, Thrombocytopenia
