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Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorTorres, W.
dc.contributor.authorMorillo, V.
dc.contributor.authorSuarez, M.K.
dc.contributor.authorParra, H.
dc.contributor.authorLameda, V.
dc.contributor.authorNava, M.
dc.contributor.authorD'Marco, L.
dc.contributor.authorPuchades, M.J.
dc.contributor.authorMedina, O.
dc.contributor.authorGuerra-Torres, X.E.
dc.contributor.authorBermúdez, V.
dc.date.accessioned2023-08-28T16:32:52Z
dc.date.available2023-08-28T16:32:52Z
dc.date.issued2021
dc.description.abstractLa infección por SARS-CoV-2 se ha convertido en un problema mundial de salud pública. Su presentación clínica es variada, desde benigna hasta un síndrome de distrés respiratorio agudo, afectación sistémica y fallo multiorgánico. La severidad del cuadro clínico depende de factores biológicos del virus y del huésped y de comorbilidades como la enfermedad renal. Además, la interacción entre el virus, la enzima convertidora de angiotensina 2 y la respuesta inmunológica exacerbada podría conducir al desarrollo de lesión renal aguda. Sin embargo, las implicaciones de la infección por SARSCoV-2 sobre las células renales, las repercusiones pronósticas en los pacientes con enfermedad renal crónica y su efecto a largo plazo sobre la función renal no están del todo claras. El objetivo es revisar el papel del SARSCoV-2 en la enfermedad renal aguda y crónica, y sus posibles mecanismos patogénicos en la afectación renal.spa
dc.description.abstractThe SARS-CoV-2 infection has become as a worldwide public health emergency. It exhibits a variety of clinical presentations, ranging from benign to acute respiratory distress syndrome, systemic involvement, and multiorganic failure. The severity of the clinical picture depends on host and virus biological features and the presence of comorbidities such as chronic kidney disease. In addition, the interaction between the virus, angiotensin-converting enzyme 2, and the exacerbated immune response could lead to the development of acute kidney injury. However, the implications of SARSCoV-2 infection on renal cells, the prognosis of patients with chronic kidney disease, and the long-term behavior of renal function are not entirely understood. This review aims to explore the role of SARS-CoV-2 in acute and chronic kidney disease and the possible pathogenic mechanisms of renal involvement.eng
dc.format.mimetypepdfspa
dc.identifier.doihttps://doi.org/10.23938/ASSN.0973
dc.identifier.issn11376627
dc.identifier.urihttps://hdl.handle.net/20.500.12442/13225
dc.language.isospaeng
dc.publisherGobierno de Navarraspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAnales del Sistema Sanitario de Navarraspa
dc.sourceVol. 44 No. 3 (2021)
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectEnzima convertidora de angiotensina 2.spa
dc.subjectEnfermedad renal crónicaspa
dc.subjectLesión renal agudaspa
dc.subjectAngiotensin-converting enzyme 2.eng
dc.subjectChronic kidney diseaseeng
dc.subjectAcute kidney injuryeng
dc.titleMecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecularspa
dc.title.translatedPathogenic mechanisms of SARS-CoV-2 infection and kidney disease: a clinical and molecular perspectiveeng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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