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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva

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datacite.rightshttp://purl.org/coar/access_right/c_16ec
dc.contributor.advisorNavarro Quiroz, Elkin
dc.contributor.advisorVilla Medina, Joe Luis
dc.contributor.advisorPacheco Londoño, Leonardo Carlos
dc.contributor.authorEspinosa Garavito, Alberto Carlos
dc.date.accessioned2024-05-15T14:19:48Z
dc.date.available2024-05-15T14:19:48Z
dc.date.issued2024
dc.description.abstractLa hipertensión arterial (HA) y la enfermedad renal crónica (ERC) presentan una carga sanitaria global considerable, con la HA actuando como un factor de riesgo silente pero potente para la ERC. El seguimiento de la progresión de la ERC en pacientes con HA es fundamental para prevenir el avance hacia la insuficiencia renal y las comorbilidades asociadas. Sin embargo, los métodos convencionales de detección, basados en la medición de la presión arterial y en biomarcadores como la proteinuria y la creatinina sérica, a menudo fallan en identificar las etapas tempranas del daño renal.spa
dc.description.abstractHigh blood pressure (AH) and chronic kidney disease (CKD) present a considerable global health burden, with AH acting as a silent but potent risk factor for CKD. Monitoring the progression of CKD in patients with AH is essential to prevent progression to renal failure and associated comorbidities. However, conventional screening methods, based on blood pressure measurement and biomarkers such as proteinuria and serum creatinine, often fail to identify the early stages of kidney damage.eng
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/20.500.12442/14644
dc.language.isospa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccesseng
dc.subjectHipertensiónspa
dc.subjectDaño renalspa
dc.subjectEspectroscopia Raman de superficie mejoradaspa
dc.subjectNanopartículas de orospa
dc.subjectAnticuerposspa
dc.subjectOrinaspa
dc.subjectQuimiometríaspa
dc.subjectHypertensionspa
dc.subjectRenal damageeng
dc.subjectSurface-enhanced Raman spectroscopyeng
dc.subjectGold nanoparticleseng
dc.subjectAntibodieseng
dc.subjectUrineeng
dc.subjectChemometricseng
dc.titleDiseño y evaluación de un prototipo de test para detección de nefropatía hipertensivaspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.spaTesis de doctorado
dcterms.referencesM. M. Lopera-Medina, “La enfermedad renal crónica en Colombia: Necesidades en salud y respuesta del Sistema General de Seguridad Social en Salud,” Revista Gerencia y Politicas de Salud, vol. 15, no. 30, pp. 212–233, Jan. 2016, doi: 10.11144/Javeriana.rgyps15-30.erccspa
dcterms.referencesS. D. Crowley and T. M. Coffman, “The inextricable role of the kidney in hypertension,” Journal of Clinical Investigation. 2014. doi: 10.1172/JCI72274.eng
dcterms.referencesB. Williams et al., “2018 ESC/ESH Guidelines for themanagement of arterial hypertension,” European Heart Journal, vol. 39, no. 33. Oxford University Press, pp. 3021–3104, Sep. 01, 2018. doi: 10.1093/eurheartj/ehy339.eng
dcterms.referencesB. Setters and H. M. Holmes, “Hypertension in the Older Adult,” Prim Care, vol. 44, no. 3, p. 529, Sep. 2017, doi: 10.1016/J.POP.2017.05.002.eng
dcterms.referencesP. M. O’Shea, T. P. Griffin, and M. Fitzgibbon, “Hypertension: The role of biochemistry in the diagnosis and management,” Clin Chim Acta, vol. 465, pp. 131–143, Feb. 2017, doi: 10.1016/J.CCA.2016.12.014eng
dcterms.referencesS. M. Hamrahian and B. Falkner, “Hypertension in chronic kidney disease,” Adv Exp Med Biol, vol. 956, pp. 307–325, 2017, doi: 10.1007/5584_2016_84.eng
dcterms.referencesD. Tousoulis, “Arterial hypertension: New concepts in diagnosis and treatment?,” Hellenic Journal of Cardiology, vol. 61, no. 3, pp. 145–147, May 2020, doi: 10.1016/J.HJC.2020.08.003eng
dcterms.referencesB. Zhou et al., “Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 populationrepresentative studies with 104 million participants,” The Lancet, vol. 398, no. 10304, pp. 957–980, Sep. 2021, doi: 10.1016/S0140-6736(21)01330-1.eng
dcterms.references“Día mundial de la hipertensión arterial 2022 | Cuenta de Alto Costo.” Accessed: Oct. 10, 2022. [Online]. Available: https://cuentadealtocosto.org/site/general/diamundial-de-la-hipertension-arterial-2022/spa
dcterms.references“Situación de la enfermedad renal crónica, la hipertensión arterial y diabetes mellitus en Colombia 2020 | Cuenta de Alto Costo.” Accessed: Oct. 11, 2022. [Online]. Available: https://cuentadealtocosto.org/site/publicaciones/situacion-de-laenfermedad-renal-cronica-la-hipertension-arterial-y-diabetes-mellitus-en-colombia2020/?1665593257100spa
dcterms.referencesFondo Colombiano de Enfermedades de Alto Costo Cuenta de Alto Costo (CAC), “Situación de la enfermedad renal crónica, la hipertensión arterial y la diabetes mellitus en Colombia 2022,” Bogotá, D.C., 2023.spa
dcterms.referencesL. Acuña, P. Sánchez, L. A. Soler, and L. F. Alvis, “Enfermedad renal en Colombia: prioridad para la gestión de riesgo Investigación original.”spa
dcterms.referencesJ. B. Kopp et al., “Podocytopathies,” Nat Rev Dis Primers, vol. 6, no. 1, Dec. 2020, doi: 10.1038/s41572-020-0196-7.eng
dcterms.referencesL. H. de Morais Pereira et al., “Podocin and uPAR are good biomarkers in cases of Focal and segmental glomerulosclerosis in pediatric renal biopsies,” PLoS One, vol. 14, no. 6, Jun. 2019, doi: 10.1371/journal.pone.0217569.eng
dcterms.referencesM. Liu et al., “Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling,” Nat Commun, vol. 8, no. 1, Dec. 2017, doi: 10.1038/s41467-017-00498-4.eng
dcterms.referencesH. Wang et al., “Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytes,” Commun Biol, vol. 4, no. 1, Dec. 2021, doi: 10.1038/s42003-021-02209-8.eng
dcterms.referencesS. Mennuni, S. Rubattu, G. Pierelli, G. Tocci, C. Fofi, and M. Volpe, “Hypertension and kidneys: Unraveling complex molecular mechanisms underlying hypertensive renal damage,” Journal of Human Hypertension, vol. 28, no. 2. pp. 74–79, 2014. doi: 10.1038/jhh.2013.55.eng
dcterms.referencesS. e Arango, “Biomarcadores para la evaluación de riesgo en la salud humana,” Rev. Fac. Nac. Salud Pública, vol. 30, pp. 75–82, 2012.spa
dcterms.referencesR. G. Fassett, S. K. Venuthurupalli, G. C. Gobe, J. S. Coombes, M. A. Cooper, and W. E. Hoy, “Biomarkers in chronic kidney disease: A review,” Kidney Int, vol. 80, no. 8, pp. 806–821, 2011, doi: 10.1038/ki.2011.198.eng
dcterms.referencesM. A. Knepper, “Common sense approaches to urinary biomarker study design.,” J Am Soc Nephrol, vol. 20, no. 6, pp. 1175–8, Jun. 2009, doi: 10.1681/ASN.2009030321eng
dcterms.referencesM. I. Yilmaz et al., “Soluble TWEAK plasma levels as a novel biomarker of endothelial function in patients with chronic kidney disease,” Clinical Journal of the American Society of Nephrology, vol. 4, no. 11, pp. 1716–1723, 2009, doi: 10.2215/CJN.02760409.eng
dcterms.referencesK. D. Liu et al., “Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease,” Kidney Int, vol. 83, no. 5, pp. 909–914, 2013, doi: 10.1038/ki.2012.458eng
dcterms.referencesV. Menon et al., “C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease,” Kidney Int, vol. 68, no. 2, pp. 766–772, 2005, doi: 10.1111/j.1523-1755.2005.00455.xeng
dcterms.referencesE. L. Penne et al., “Role of residual kidney function and convective volume on change in β2-microglobulin levels in hemodiafiltration patients,” Clinical Journal of the American Society of Nephrology, vol. 5, no. 1, pp. 80–86, 2010, doi: 10.2215/CJN.03340509eng
dcterms.referencesS. E. Jones and C. Jomary, “Molecules in focus Clusterin,” 2002.eng
dcterms.referencesZ. Khan and M. Pandey, “Role of kidney biomarkers of chronic kidney disease: An update,” Saudi J Biol Sci, vol. 21, no. 4, pp. 294–299, 2014, doi: 10.1016/j.sjbs.2014.07.003.eng
dcterms.referencesV. S. Sabbisetti et al., “Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes,” Journal of the American Society of Nephrology, vol. 25, no. 10, pp. 2177–2186, 2014, doi: 10.1681/ASN.2013070758.eng
dcterms.referencesT. Y. Du et al., “Circulating serum trefoil factor 3 (TFF3) is dramatically increased in chronic kidney disease,” PLoS One, vol. 8, no. 11, pp. 6–11, 2013, doi: 10.1371/journal.pone.0080271.eng
dcterms.referencesS. A. Price et al., “Characterization of Renal Papillary Antigen 1 (RPA-1), a Biomarker of Renal Papillary Necrosis,” Toxicol Pathol, vol. 38, no. 3, pp. 346–358, 2010, doi: 10.1177/0192623310362246.eng
dcterms.referencesE. D. Siew et al., “Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes,” Clinical Journal of the American Society of Nephrology, vol. 5, no. 8, pp. 1497–1505, 2010, doi: 10.2215/CJN.09061209.eng
dcterms.referencesG. Mayer, “Capillary rarefaction, hypoxia, VEGF and angiogenesis in chronic renal disease,” Nephrology Dialysis Transplantation, vol. 26, no. 4, pp. 1132–1137, 2011, doi: 10.1093/ndt/gfq832.eng
dcterms.referencesÁ. Fernández-Galiana, O. Bibikova, S. Vilms Pedersen, and M. M. Stevens, “Fundamentals and Applications of Raman-Based Techniques for the Design and Development of Active Biomedical Materials,” Advanced Materials. John Wiley and Sons Inc, 2023. doi: 10.1002/adma.202210807.eng
dcterms.referencesG. Cutshaw, S. Uthaman, N. Hassan, S. Kothadiya, X. Wen, and R. Bardhan, “The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine,” Chem Rev, Jul. 2023, doi: 10.1021/acs.chemrev.2c00897.eng
dcterms.referencesN. M. Ralbovsky and I. K. Lednev, “Towards development of a novel universal medical diagnostic method: Raman spectroscopy and machine learning,” Chemical Society Reviews, vol. 49, no. 20. Royal Society of Chemistry, pp. 7428–7453, Oct. 21, 2020. doi: 10.1039/d0cs01019g.eng
dcterms.referencesN. M. Ralbovsky and I. K. Lednev, “Raman spectroscopy and chemometrics: A potential universal method for diagnosing cancer,” Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 219. Elsevier B.V., pp. 463–487, Aug. 05, 2019. doi: 10.1016/j.saa.2019.04.067.eng
dcterms.referencesK. Kong, C. Kendall, N. Stone, and I. Notingher, “Raman spectroscopy for medical diagnostics - From in-vitro biofluid assays to in-vivo cancer detection,” Advanced Drug Delivery Reviews, vol. 89. Elsevier B.V., pp. 121–134, Jul. 15, 2015. doi: 10.1016/j.addr.2015.03.009.eng
dcterms.referencesV. Moisoiu et al., “Breast cancer diagnosis by surface-enhanced raman scattering (SERS) of urine,” Applied Sciences (Switzerland), vol. 9, no. 4, Feb. 2019, doi: 10.3390/app9040806eng
dcterms.referencesY. Ma, J. Chi, Z. Zheng, A. Attygalle, I. Y. Kim, and H. Du, “Therapeutic prognosis of prostate cancer using surface-enhanced Raman scattering of patient urine and multivariate statistical analysis,” J Biophotonics, vol. 14, no. 1, Jan. 2021, doi: 10.1002/jbio.202000275.eng
dcterms.referencesJ. Lin et al., “Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages,” Biomed Opt Express, vol. 11, no. 12, p. 7109, Dec. 2020, doi: 10.1364/boe.406097.eng
dcterms.referencesR. Pappu, A. Prakasarao, K. Dornadula, and G. Singaravelu, “Raman spectroscopic characterization of urine of normal and cervical cancer subjects,” in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, SPIE, Feb. 2017, p. 1005404. doi: 10.1117/12.2255878.eng
dcterms.referencesJ. L. Flores-Guerrero et al., “Novel assessment of urinary albumin excretion in type 2 diabetes patients by Raman spectroscopy,” Diagnostics, vol. 10, no. 3, Feb. 2020, doi: 10.3390/diagnostics10030141.eng
dcterms.referencesE. E. de Souza Vieira, J. A. M. Bispo, L. Silveira, and A. B. Fernandes, “Discrimination model applied to urinalysis of patients with diabetes and hypertension aiming at diagnosis of chronic kidney disease by Raman spectroscopy,” Lasers Med Sci, vol. 32, no. 7, pp. 1605–1613, Sep. 2017, doi: 10.1007/S10103-017-2288-5.eng
dcterms.referencesC. Chen et al., “Urine Raman spectroscopy for rapid and inexpensive diagnosis of chronic renal failure (CRF) using multiple classification algorithms,” Optik (Stuttg), vol. 203, Feb. 2020, doi: 10.1016/j.ijleo.2019.164043.eng
dcterms.referencesS. Aitekenov et al., “Surface-enhanced Raman spectroscopy (SERS) for protein determination in human urine,” Sens Biosensing Res, vol. 38, Dec. 2022, doi: 10.1016/j.sbsr.2022.100535.eng
dcterms.referencesE. I. Nikelshparg et al., “Detection of Hypertension-Induced Changes in Erythrocytes by SERS Nanosensors,” Biosensors (Basel), vol. 12, no. 1, Jan. 2022, doi: 10.3390/bios12010032.eng
dcterms.referencesE. E. de Sousa Vieira, L. Silveira, H. C. Carvalho, J. A. M. Bispo, F. B. Fernandes, and A. B. Fernandes, “Biochemical Analysis of Urine Samples from Diabetic and Hypertensive Patients without Renal Dysfunction Using Spectrophotometry and Raman Spectroscopy Techniques Aiming Classification and Diagnosis,” Bioengineering, vol. 9, no. 10, Oct. 2022, doi: 10.3390/bioengineering9100500.eng
dcterms.referencesH. Yang et al., “Noninvasive and prospective diagnosis of coronary heart disease with urine using surface-enhanced Raman spectroscopy,” Analyst, vol. 143, no. 10, pp. 2235–2242, May 2018, doi: 10.1039/c7an02022h.eng
dcterms.referencesT. Ware, “Chronic kidney disease,” InnovAiT: Education and inspiration for general practice, vol. 11, no. 1, pp. 35–40, 2018, doi: 10.1177/1755738017738272eng
dcterms.referencesC. M. M. Lawes, S. Vander Hoorn, and A. Rodgers, “Global burden of bloodpressure-related disease, 2001,” 2008. [Online]. Available: www.thelancet.comeng
dcterms.referencesS. Dolff et al., “Urinary CD8+ T-cell counts discriminate between active and inactive lupus nephritis.,” Arthritis Res Ther, vol. 15, no. 1, p. R36, 2013, doi: 10.1186/ar4189.eng
dcterms.referencesF. Gil Hernández, “The role of biomarkers in human toxicology.”eng
dcterms.referencesC. R. Parikh, “Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit,” Journal of the American Society of Nephrology, vol. 16, no. 10, pp. 3046–3052, 2005, doi: 10.1681/ASN.2005030236.eng
dcterms.referencesL. Cirillo et al., “Defining diagnostic trajectories in patients with podocytopathies,” Clinical Kidney Journal, vol. 15, no. 11. Oxford University Press, pp. 2006–2019, Nov. 01, 2022. doi: 10.1093/ckj/sfac123.eng
dcterms.referencesM. Nagata, “Podocyte injury and its consequences,” Kidney International, vol. 89, no. 6. Elsevier B.V., pp. 1221–1230, 2016. doi: 10.1016/j.kint.2016.01.012.eng
dcterms.referencesZ. Wang, H. Bao, Y. Ge, S. Zhuang, A. Peng, and R. Gong, “Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition,” Br J Pharmacol, vol. 172, no. 3, pp. 895–909, 2015, doi: 10.1111/bph.12952.eng
dcterms.referencesM. A. Martín-Gómez et al., “Glomerulonefritis colapsante con marcadores de desdiferenciación podocitaria en síndrome hemofagocítico secundario a linfoma hepatoesplénico de células T,” Biomedica, vol. 38, no. 4, pp. 456–462, 2018, doi: 10.7705/biomedica.v38i4.3893spa
dcterms.referencesM. Sekulic and S. Pichler Sekulic, “A compendium of urinary biomarkers indicative of glomerular podocytopathy,” Pathology Research International, vol. 2013. 2013. doi: 10.1155/2013/782395.eng
dcterms.referencesC. de Souza et al., “Nephrin and podocin mRNA detection in urine sediment of dogs with chronic kidney disease: Preliminary observations,” Journal of Veterinary Research (Poland), vol. 66, no. 2, pp. 281–288, Jun. 2022, doi: 10.2478/jvetres2022-0019.eng
dcterms.referencesB. Szczepankiewicz et al., “Early detection of active glomerular lesions in dogs and cats using podocin,” Journal of Veterinary Research (Poland), vol. 63, no. 4. Sciendo, pp. 573–577, Dec. 01, 2019. doi: 10.2478/jvetres-2019-0062.eng
dcterms.referencesB. Szczepankiewicz et al., “Evaluation of tryptic podocin peptide in urine sediment using LC-MS-MRM method as a potential biomarker of glomerular injury in dogs with clinical signs of renal and cardiac disorders,” Molecules, vol. 24, no. 17, Aug. 2019, doi: 10.3390/molecules24173088.eng
dcterms.referencesN. Siwińska et al., “Evaluation of podocin in urine in horses using qualitative and quantitative methods,” PLoS One, vol. 15, no. 10 October, Oct. 2020, doi: 10.1371/journal.pone.0240586.eng
dcterms.referencesA. J. Won et al., “Discovery of urinary metabolomic biomarkers for early detection of acute kidney injury,” Mol Biosyst, vol. 12, no. 1, pp. 133–144, 2016, doi: 10.1039/c5mb00492f.eng
dcterms.referencesL. H. de Morais Pereira et al., “Podocin and uPAR are good biomarkers in cases of Focal and segmental glomerulosclerosis in pediatric renal biopsies,” PLoS One, vol. 14, no. 6, Jun. 2019, doi: 10.1371/journal.pone.0217569.eng
dcterms.referencesM. Suvanto, T. Jahnukainen, M. Kestilä, and H. Jalanko, “Podocyte proteins in congenital and minimal change nephrotic syndrome,” Clin Exp Nephrol, vol. 19, no. 3, pp. 481–488, Jun. 2015, doi: 10.1007/s10157-014-1020-z.eng
dcterms.referencesP. B. Shankar, R. Nada, K. Joshi, A. Kumar, C. S. Rayat, and V. Sakhuja, “Podocin and Beta Dystroglycan expression to study Podocyte-Podocyte and basement membrane matrix connections in adult protienuric states,” Diagn Pathol, vol. 9, no. 1, Feb. 2014, doi: 10.1186/1746-1596-9-40eng
dcterms.referencesG. Cara-Fuentes et al., “CD80, suPAR and Nephrotic Syndrome in a case of NPHS2 mutation,” Nefrologia, vol. 33, no. 5, pp. 727–731, 2013, doi: 10.3265/Nefrologia.pre2013.Jun.12085.eng
dcterms.referencesT. Martineau, M. Boutin, A. M. Côté, B. Maranda, D. G. Bichet, and C. Auray-Blais, “Tandem mass spectrometry analysis of urinary podocalyxin and podocin in the investigation of podocyturia in women with preeclampsia and Fabry disease patients,” Clinica Chimica Acta, vol. 495, pp. 67–75, Aug. 2019, doi: 10.1016/j.cca.2019.03.1615.eng
dcterms.referencesR. Bąchor et al., “Detection of podocin in human urine sediment samples by charge derivatization and Lc-Ms-Mrm method,” Int J Mol Sci, vol. 21, no. 9, May 2020, doi: 10.3390/ijms21093225.eng
dcterms.referencesS. Lee et al., “Nanoparticle-Enabled Multiplexed Electrochemical Immunoassay for Detection of Surface Proteins on Extracellular Vesicles.”eng
dcterms.referencesB. Saugel, K. Kouz, A. S. Meidert, L. Schulte-Uentrop, and S. Romagnoli, “How to measure blood pressure using an arterial catheter: A systematic 5-step approach,” Critical Care, vol. 24, no. 1. BioMed Central, Apr. 24, 2020. doi: 10.1186/s13054- 020-02859-w.eng
dcterms.referencesK. Javorka, “History of Blood Pressure Measurement in Newborns and Infants,” Physiological Research, vol. 72, no. 5. Czech Academy of Sciences, pp. 543–555, 2023. doi: 10.33549/physiolres.935173.eng
dcterms.references“Understanding Blood Pressure Readings | American Heart Association.” Accessed: Dec. 26, 2022. [Online]. Available: https://www.heart.org/en/healthtopics/high-blood-pressure/understanding-blood-pressure-readingseng
dcterms.referencesB. Weisser, T. Mengden, R. Dü, H. Vetter, and W. Vetter, “Normal Values of Blood Pressure Self-Measurement in View of the 1999 World Health OrganizationInternational Society of Hypertension Guidelines,” 2000. [Online]. Available: https://academic.oup.com/ajh/article/13/8/940/162487eng
dcterms.referencesS. Magder, “The meaning of blood pressure Luigi Forni,” Critical Care, vol. 22, no. 1. BioMed Central Ltd, Oct. 11, 2018. doi: 10.1186/s13054-018-2171-1.eng
dcterms.referencesF. L. Plavnik, S. A. Ajzen, D. M. J. Christofalo, C. S. P. Barbosa, and O. Kohlmann, “Endothelial function in normotensive and high-normal hypertensive subjects,” J Hum Hypertens, vol. 21, no. 6, pp. 467–472, Jun. 2007, doi: 10.1038/sj.jhh.1002164.eng
dcterms.referencesR. Gargiulo, F. Suhail, and E. V. Lerma, “Hypertension and chronic kidney disease,” Disease-a-Month, vol. 61, no. 9. Mosby Inc., pp. 387–395, Sep. 01, 2015. doi: 10.1016/j.disamonth.2015.07.003eng
dcterms.references“Anatomy and physiology series: infrastructure of the kidney,” 2013eng
dcterms.referencesR. M. Soriano, D. Penfold, and S. W. Leslie, “Anatomy, Abdomen and Pelvis, Kidneys,” StatPearls, Jul. 2022, Accessed: Nov. 05, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK482385/eng
dcterms.referencesC. S. Bowdino, J. Owens, and P. M. Shaw, “Anatomy, Abdomen and Pelvis, Renal Veins,” StatPearls, Jan. 2022, Accessed: Nov. 05, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK538298/eng
dcterms.referencesE. Vazquez Martul and M. Praga, “Anatomía patológica y nefrología. La necesidad de un cambio,” Nefrología, vol. 38, no. 3, pp. 247–249, May 2018, doi: 10.1016/j.nefro.2017.11.002.spa
dcterms.referencesP. Anil Kumar, G. I. Welsh, M. A. Saleem, and R. K. Menon, “Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus,” Frontiers in Endocrinology, vol. 5, no. SEP. Frontiers Research Foundation, 2014. doi: 10.3389/fendo.2014.00151.eng
dcterms.references] I. Ogobuiro and F. Tuma, “Physiology, Renal,” StatPearls, Jul. 2022, Accessed: Nov. 05, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK538339/eng
dcterms.referencesA. Pätäri-Sampo, P. Ihalmo, and H. Holthöfer, “Molecular basis of the glomerular filtration: Nephrin and the emerging protein complex at the podocyte slit diaphragm,” Annals of Medicine, vol. 38, no. 7. pp. 483–492, Nov. 01, 2006. doi: 10.1080/07853890600978149eng
dcterms.referencesK. Tryggvason, “Unraveling the Mechanisms of Glomerular Ultrafiltration: Nephrin, a Key Component of the Slit Diaphragm,” 1999.eng
dcterms.references“Renal system 1 the anatomy and physiology of the kidneys”eng
dcterms.referencesJ. E. Hall, “The kidney, hypertension, and obesity,” in Hypertension, Mar. 2003, pp. 625–633. doi: 10.1161/01.HYP.0000052314.95497.78.eng
dcterms.referencesA. C. Webster, E. V. Nagler, R. L. Morton, and P. Masson, “Chronic Kidney Disease,” The Lancet, vol. 389, no. 10075, pp. 1238–1252, 2017, doi: 10.1016/S0140-6736(16)32064-5.eng
dcterms.referencesSica Domenic A., “The Kidney and Hypertension causes and Treatment,” The Kidney and Hypertension, vol. 10, no. ID: 8189, pp. 541–548, 2008.eng
dcterms.referencesA. K. B. D. G. V. Karen A. Griffin, “Hypertension and Kidney Damage,” The journal of clinical Hypertension, vol. 8, no. 1524–6175, 2006eng
dcterms.referencesB. E. Noresson M Hallback and A. Hjalmarsson, “Structural ‘Resetting’ of the Coronary Vascular Bed in Spontaneously Hypertensive Rats,” 1977eng
dcterms.referencesM. E. Pueyo, W. Gonzalez, A. Nicoletti, F. Savoie, J.-F. Arnal, and J.-B. Michel, “Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-B Activation Induced by Intracellular Oxidative Stress,” 2000. [Online]. Available: http://www.atvbaha.orgeng
dcterms.referencesH. Pavenstädt, W. Kriz, and M. Kretzler, “Cell biology of the glomerular podocyte,” Physiological Reviews, vol. 83, no. 1. American Physiological Society, pp. 253– 307, 2003. doi: 10.1152/physrev.00020.2002eng
dcterms.referencesN. Queisser, P. I. Oteiza, H. Stopper, R. G. Oli, and N. Schupp, “Aldosterone induces oxidative stress, oxidative DNA damage and NF-κB-activation in kidney tubule cells,” Mol Carcinog, vol. 50, no. 2, pp. 123–135, Feb. 2011, doi: 10.1002/mc.20710eng
dcterms.referencesC. S. Wilcox, “Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?,” Am J Physiol Regul Integr Comp Physiol, vol. 289, pp. 913– 935, 2005, doi: 10.1152/ajpregu.00250.2005.-There.eng
dcterms.referencesB. Ponnuchamy and R. A. Khalil, “Cellular mediators of renal vascular dysfunction in hypertension,” Am J Physiol Regul Integr Comp Physiol, vol. 296, pp. 1001– 1018, 2009, doi: 10.1152/ajpregu.90960.2008.-Theeng
dcterms.referencesN. Frey and E. N. Olson, “Cardiac Hypertrophy: The Good, the Bad, and the Ugly,” Annual Review of Physiology, vol. 65. pp. 45–79, 2003. doi: 10.1146/annurev.physiol.65.092101.142243.eng
dcterms.referencesC. R. Neal et al., “Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions,” Am J Physiol Renal Physiol, vol. 293, pp. 1787–1798, 2007, doi: 10.1152/ajprenal.00157.2007.-Production.eng
dcterms.referencesM. Nagase and T. Fujita, “Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease,” Nature Reviews Nephrology, vol. 9, no. 2. pp. 86–98, Feb. 2013. doi: 10.1038/nrneph.2012.282.eng
dcterms.referencesS. J. Shankland, “The podocyte’s response to injury: Role in proteinuria and glomerulosclerosis,” Kidney International, vol. 69, no. 12. pp. 2131–2147, Jun. 03, 2006. doi: 10.1038/sj.ki.5000410eng
dcterms.referencesP. A. Doris, “Genetic susceptibility to hypertensive renal disease,” Cellular and Molecular Life Sciences, vol. 69, no. 22. pp. 3751–3763, Nov. 2012. doi: 10.1007/s00018-012-0996-3.eng
dcterms.referencesJ. D. Lundgren, J. Baxter, S. G. Deeks, and H. C. Lane, “Biomarkers in HIV disease,” Current Opinion in HIV and AIDS, vol. 5, no. 6. pp. 459–462, Nov. 2010. doi: 10.1097/COH.0b013e32833f2ed6eng
dcterms.referencesE. A. Lock and J. V Bonventre, “Biomarkers in translation; past, present and future.,” Toxicology, vol. 245, no. 3, pp. 163–6, Mar. 2008, doi: 10.1016/j.tox.2007.12.004.eng
dcterms.referencesChronic Kidney Disease Prognosis Consortium et al., “Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis.,” Lancet, vol. 375, no. 9731, pp. 2073–81, Jun. 2010, doi: 10.1016/S0140-6736(10)60674-5.eng
dcterms.referencesU. Salzer and R. Prohaska, “Brief report Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts,” 2001.eng
dcterms.referencesM. Seijas, C. Baccino, N. Nin, and J. A. Lorente, “Definición y biomarcadores de daño renal agudo: Nuevas perspectivas,” Medicina Intensiva, vol. 38, no. 6. Ediciones Doyma, S.L., pp. 376–385, 2014. doi: 10.1016/j.medin.2013.09.001.spa
dcterms.referencesF. Lombi, A. Muryan, R. Canzonieri, and H. Trimarchi, “Biomarkers in acute kidney injury: Evidence or paradigm?,” Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, vol. 36, no. 4. pp. 339–346, Jul. 01, 2016. doi: 10.1016/j.nefro.2016.01.012.eng
dcterms.referencesN. Boute et al., “NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome,” 2000. [Online]. Available: http://genetics.nature.com/supplemetary_info/eng
dcterms.referencesA. Berdeli et al., “NPHS2 (podicin) mutations in Turkish children with idiopathic nephrotic syndrome,” Pediatric Nephrology, vol. 22, no. 12, pp. 2031–2040, Dec. 2007, doi: 10.1007/s00467-007-0595-yeng
dcterms.referencesS. K. N. Mulukala et al., “Structural features and oligomeric nature of human podocin domain,” Biochem Biophys Rep, vol. 23, Sep. 2020, doi: 10.1016/j.bbrep.2020.100774.eng
dcterms.referencesK. Schwarz et al., “Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin,” Journal of Clinical Investigation, vol. 108, no. 11, pp. 1621–1629, 2001, doi: 10.1172/JCI200112849.eng
dcterms.referencesT. B. Huber, B. Schermer, and T. Benzing, “Podocin organizes ion channel-lipid supercomplexes: Implications for mechanosensation at the slit diaphragm,” Nephron - Experimental Nephrology, vol. 106, no. 2. Jun. 2007. doi: 10.1159/000101789.eng
dcterms.referencesM. Varadi et al., “AlphaFold Protein Structure Database: Massively expanding the structural coverage of protein-sequence space with high-accuracy models,” Nucleic Acids Res, vol. 50, no. D1, pp. D439–D444, Jan. 2022, doi: 10.1093/nar/gkab1061.eng
dcterms.referencesS. K. N. Mulukala, R. Nishad, L. P. Kolligundla, M. A. Saleem, N. P. Prabhu, and A. K. Pasupulati, “In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants,” IUBMB Life, pp. 578–588, Jul. 2016, doi: 10.1002/iub.1515.eng
dcterms.referencesL. E. Hood’, “Immunoglobulin Genetics,” Amer J Hum Genet, vol. 24, pp. 702–704, 1972.eng
dcterms.referencesH. W. Schroeder and L. Cavacini, “Structure and function of immunoglobulins,” Journal of Allergy and Clinical Immunology, vol. 125, no. 2 SUPPL. 2, Feb. 2010, doi: 10.1016/j.jaci.2009.09.046.eng
dcterms.referencesBradley John, “Immunoglobulins,” J Med Genet, pp. 11–80, 1974.eng
dcterms.referencesZ. Chen, X. Qiu, and J. Gu, “Immunoglobulin expression in non-lymphoid lineage and neoplastic cells,” American Journal of Pathology, vol. 174, no. 4. Elsevier Inc., pp. 1139–1148, 2009. doi: 10.2353/ajpath.2009.080879.eng
dcterms.referencesS. L. Maibom-Thomsen et al., “Immunoglobulin G structure and rheumatoid factor epitopes,” PLoS One, vol. 14, no. 6, Jun. 2019, doi: 10.1371/journal.pone.0217624.eng
dcterms.referencesN. Kumar, C. P. Arthur, C. Ciferri, and M. L. Matsumoto, “Structure of the human secretory immunoglobulin M core,” Structure, vol. 29, no. 6, pp. 564-571.e3, Jun. 2021, doi: 10.1016/j.str.2021.01.002eng
dcterms.referencesS. Pan, N. Manabe, and Y. Yamaguchi, “3d structures of iga, igm, and components,” International Journal of Molecular Sciences, vol. 22, no. 23. MDPI, Dec. 01, 2021. doi: 10.3390/ijms222312776eng
dcterms.referencesC. Nacional de Verificación de Maquinaria -María José Quintana San José -Miren Agurtzane Zugasti Macazaga -María del Carmen Uribe Zallo -Begoña Uribe Ortega, C. Nacional de Nuevas Tecnologías -Virginia Gálvez Pérez -María Encarnación Sousa Rodríguez -María Teresa Sánchez Cabo -Mercedes Colorado Soriano -Josefa Aguilar Franco Colaboradores, and -Rosa Méndez Zurutuza - Natividad Montes Beneitez -José Maria Rojo Aparicio -Antonia Hernández Castañeda -Silvia Torres Ruiz, “Elaborado por.” [Online]. Available: http://publicacionesoficiales.boe.eshttp://www.insht.es/catalogopublicaciones/spa
dcterms.referencesF. De Química and L. Casas Quiroga, “SÍNTESIS Y CARACTERIZACIÓN DE NANOPARTÍCULAS DE ORO CON RECUBRIMIENTO POLIMÉRICO QUIRAL,” 2015.spa
dcterms.referencesD. A. Cruz, M. C. Rodríguez, J. M. López, V. M. Herrera, A. G. Orive, and A. H. Creus, “NANOPARTÍCULAS METÁLICAS Y PLASMONES DE SUPERFICIE: UNA RELACIÓN PROFUNDA METALLIC NANOPARTICLES AND SURFACE PLASMONS: A DEEP RELATIONSHIP.” [Online]. Available: http://www.exeedu.com/publishing.cl/av_cienc_ing/67spa
dcterms.referencesM.-C. Daniel and D. Astruc, “Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology,” 2004, doi: 10.1021/cr030698.eng
dcterms.referencesM. Auffan, J. Rose, J. Y. Bottero, G. V. Lowry, J. P. Jolivet, and M. R. Wiesner, “Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective,” Nature Nanotechnology, vol. 4, no. 10. Nature Publishing Group, pp. 634–641, 2009. doi: 10.1038/nnano.2009.242.eng
dcterms.referencesB. John Turkevich, P. Cooper Stevenson, and J. Hillier, “A STUDY OF THE NUCLEATION AND GROWTH PROCESSES I N THE SYNTHESIS OF COLLOIDAL GOLD,” Turkevich and Hillier, 1941.eng
dcterms.referencesA. Bueno Costa, “Estudio de la conjugación de antifolatos a nanopartículas de oro,” 2015.spa
dcterms.referencesP. Mulvaney, “Surface Plasmon Spectroscopy of Nanosized Metal Particles,” 1996.eng
dcterms.referencesS. Geetha, K. K. S. Kumar, C. R. K. Rao, M. Vijayan, and D. C. Trivedi, “EMI shielding: Methods and materials - A review,” J Appl Polym Sci, vol. 112, no. 4, pp. 2073–2086, May 2009, doi: 10.1002/app.29812.eng
dcterms.referencesS. de S. Araújo, S. Paparella, D. Dondi, A. Bentivoglio, D. Carbonera, and A. Balestrazzi, “Physical methods for seed invigoration: Advantages and challenges in seed technology,” Frontiers in Plant Science, vol. 7, no. MAY2016. Frontiers Media S.A., May 12, 2016. doi: 10.3389/fpls.2016.00646.eng
dcterms.references“What is Raman Spectroscopy? - HORIBA.” Accessed: Jan. 03, 2023. [Online]. Available: https://www.horiba.com/esp/scientific/technologies/raman-imaging-andspectroscopy/raman-spectroscopy/eng
dcterms.references“Conceptos básicos de la espectroscopia Raman.” Accessed: Jan. 03, 2023. [Online]. Available: https://www.inta.es/ExoMarsRaman/es/instrumentorls/espectroscopia-raman/#spa
dcterms.references“Espectroscopia Raman | Instrumentación, introducción y principios.” Accessed: Jan. 03, 2023. [Online]. Available: https://www.mt.com/mx/es/home/applications/L1_AutoChem_Applications/RamanSpectroscopy.htmlspa
dcterms.referencesN. Abril Díaz et al., “Espectrofometría: Espectros de absorción y cuantificación colorimétrica de biomoléculas.”spa
dcterms.referencesM. Picollo, M. Aceto, and T. Vitorino, “UV-Vis spectroscopy,” Physical Sciences Reviews, vol. 4, no. 4, Apr. 2019, doi: 10.1515/psr-2018-0008.eng
dcterms.referencesN. Narband, M. Uppal, C. W. Dunnill, G. Hyett, M. Wilson, and I. P. Parkin, “The interaction between gold nanoparticles and cationic and anionic dyes: Enhanced UV-visible absorption,” Physical Chemistry Chemical Physics, vol. 11, no. 44, pp. 10513–10518, 2009, doi: 10.1039/b909714g.eng
dcterms.referencesR. Cerbino and V. Trappe, “Differential dynamic microscopy: Probing wave vector dependent dynamics with a microscope,” Phys Rev Lett, vol. 100, no. 18, May 2008, doi: 10.1103/PhysRevLett.100.188102.eng
dcterms.referencesZ. Jia, J. Li, L. Gao, D. Yang, and A. Kanaev, “Dynamic Light Scattering: A Powerful Tool for In Situ Nanoparticle Sizing,” Colloids and Interfaces, vol. 7, no. 1. MDPI, Mar. 01, 2023. doi: 10.3390/colloids7010015.eng
dcterms.referencesB. J. Kirby and E. F. Hasselbrink, “Zeta potential of microfluidic substrates: 1. Theory, experimental techniques, and effects on separations,” Electrophoresis, vol. 25, no. 2. Wiley-VCH Verlag, pp. 187–202, 2004. doi: 10.1002/elps.200305754.eng
dcterms.referencesZ. Zhang et al., “Investigation of halide-induced aggregation of Au nanoparticles into spongelike gold,” Langmuir, vol. 30, no. 10, pp. 2648–2659, Mar. 2014, doi: 10.1021/la4046447eng
dcterms.referencesJ. E. Butler, “Enzyme-linked immunosorbent assay,” Journal of Immunoassay, vol. 21, no. 2–3. Marcel Dekker Inc., pp. 165–209, 2000. doi: 10.1080/01971520009349533.eng
dcterms.referencesM. C. Dita, “Enzyme Linked Immunosorbent Assay (ELISA),” Natural Sciences Engineering and Technology Journal, vol. 1, no. 2, pp. 29–38, Aug. 2021, doi: 10.37275/nasetjournal.v1i2.6.eng
dcterms.referencesS. Paulie, P. Perlmann, and H. Perlmann, “Enzyme Linked Immunosorbent Assay,” Cell Biology: A Laboratory Handbook, pp. 533–538, Feb. 2022, doi: 10.1016/B978- 012164730-8/50065-4eng
dcterms.references“Enzyme Linked Immunosorbent Assay - StatPearls - NCBI Bookshelf.” Accessed: Jan. 03, 2023. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK555922/eng
dcterms.referencesM. Singh, P. Weerathunge, P. D. Liyanage, E. Mayes, R. Ramanathan, and V. Bansal, “Competitive Inhibition of the Enzyme-Mimic Activity of Gd-Based Nanorods toward Highly Specific Colorimetric Sensing of l -Cysteine,” Langmuir, vol. 33, no. 38, pp. 10006–10015, Sep. 2017, doi: 10.1021/acs.langmuir.7b01926.eng
dcterms.referencesT. O. Kohl and C. A. Ascoli, “Direct competitive enzyme-linked immunosorbent assay (ELISA),” Cold Spring Harb Protoc, vol. 2017, no. 7, pp. 564–568, 2017, doi: 10.1101/pdb.prot093740.eng
dcterms.referencesK. Boguszewska, M. Szewczuk, S. Urbaniak, and B. T. Karwowski, “Review: immunoassays in DNA damage and instability detection,” Cellular and Molecular Life Sciences, vol. 76, no. 23. Birkhauser Verlag AG, pp. 4689–4704, Dec. 01, 2019. doi: 10.1007/s00018-019-03239-6.eng
dcterms.referencesK. Héberger, “Chemoinformatics-multivariate mathematical-statistical methods for data evaluation,” 2008. doi: 10.1016/B978-0-444-51980-1.50009-4.eng
dcterms.referencesR. Rousseau, B. Govaerts, M. Verleysen, and B. Boulanger, “Comparison of some chemometric tools for metabonomics biomarker identification,” Chemometrics and Intelligent Laboratory Systems, vol. 91, no. 1, pp. 54–66, Mar. 2008, doi: 10.1016/j.chemolab.2007.06.008.eng
dcterms.referencesA. Kotłowska, “Application of chemometric techniques in search of clinically applicable biomarkers of disease,” Drug Development Research, vol. 75, no. 5. Wiley-Liss Inc., pp. 283–290, 2014. doi: 10.1002/ddr.21213.eng
dcterms.referencesL. C. Lee and A. A. Jemain, “Predictive modelling of colossal ATR-FTIR spectral data using PLS-DA: Empirical differences between PLS1-DA and PLS2-DA algorithms,” Analyst, vol. 144, no. 8, pp. 2670–2678, Apr. 2019, doi: 10.1039/c8an02074deng
dcterms.referencesG. Theophilou, K. M. G. Lima, P. L. Martin-Hirsch, H. F. Stringfellow, and F. L. Martin, “ATR-FTIR spectroscopy coupled with chemometric analysis discriminates normal, borderline and malignant ovarian tissue: Classifying subtypes of human cancer,” Analyst, vol. 141, no. 2, pp. 585–594, Jan. 2016, doi: 10.1039/c5an00939aeng
dcterms.referencesB. M. Wise, J. M. Shaver, N. B. Gallagher, W. W. Rasmus, and B. R. S. Koch, “Continuum Parameter Number of LVs PRESS Chemometrics Tutorial for PLS_Toolbox and Solo.” [Online]. Available: www.eigenvector.comeng
dcterms.referencesD. Ruiz-Perez, H. Guan, P. Madhivanan, K. Mathee, and G. Narasimhan, “So you think you can PLS-DA?,” BMC Bioinformatics, vol. 21, Dec. 2020, doi: 10.1186/s12859-019-3310-7.eng
dcterms.referencesS. Roy, D. Perez-Guaita, S. Bowden, P. Heraud, and B. R. Wood, “Spectroscopy goes viral: Diagnosis of hepatitis B and C virus infection from human sera using ATR-FTIR spectroscopy,” Clinical Spectroscopy, vol. 1, p. 100001, Dec. 2019, doi: 10.1016/j.clispe.2020.100001.eng
dcterms.referencesL. C. Lee, C. Y. Liong, and A. A. Jemain, “Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: A review of contemporary practice strategies and knowledge gaps,” Analyst, vol. 143, no. 15. Royal Society of Chemistry, pp. 3526–3539, Aug. 07, 2018. doi: 10.1039/c8an00599k.eng
dcterms.referencesD. V Nguyen and D. M. Rocke, “Tumor classification by partial least squares using microarray gene expression data,” 2002eng
dcterms.referencesY. V. Zontov, O. Y. Rodionova, S. V. Kucheryavskiy, and A. L. Pomerantsev, “PLSDA – A MATLAB GUI tool for hard and soft approaches to partial least squares discriminant analysis,” Chemometrics and Intelligent Laboratory Systems, vol. 203, Aug. 2020, doi: 10.1016/j.chemolab.2020.104064.eng
dcterms.referencesC. Bouveyron and S. Girard, “Robust supervised classification with mixture models: Learning from data with uncertain labels,” Pattern Recognit, vol. 42, no. 11, pp. 2649–2658, Nov. 2009, doi: 10.1016/j.patcog.2009.03.027.eng
dcterms.referencesM. Barker and W. Rayens, “Partial least squares for discrimination,” J Chemom, vol. 17, no. 3, pp. 166–173, Mar. 2003, doi: 10.1002/cem.785.eng
dcterms.referencesL. Stahle and S. Wold, “PARTIAL LEAST SQUARES ANALYSIS WITH A MONTE CARL0 STUDY CROSS-VALIDATION FOR THE TWO-CLASS PROBLEM,” 1987.eng
dcterms.referencesF. Rohart, B. Gautier, A. Singh, and K. A. Lê Cao, “mixOmics: An R package for ‘omics feature selection and multiple data integration,” PLoS Comput Biol, vol. 13, no. 11, Nov. 2017, doi: 10.1371/journal.pcbi.1005752.fre
dcterms.referencesJ. A. Hanley and B. J. McNeil, “The Meaning and Use of the Area under a Receiver Operating Characteristic (ROC) Curve1.”eng
dcterms.referencesRoy Garcia IA; Paredes-Palcios J; Rivas-Ruis R; Flores-Pulido AA, “ROC curves: general characteristics and their usefulness in clinical practice,” Revsta Medica Instituto Mexicano del seguro social, vol. 61, Feb. 2023, doi: 10.5281/zenodo.8319791.eng
dcterms.references“Bioconjugate Techniques - Greg T. Hermanson - Google Books.” Accessed: Oct. 11, 2022. [Online]. Available: https://books.google.com.co/books?hl=en&lr=&id=6aO207lhdgC&oi=fnd&pg=PP1&dq=bioconjugate+techniques+pdf&ots=aL4Ly7IpPU&s ig=HdCGSFCW2VzBeERKxNgku2DAAVQ#v=onepage&q&f=falseeng
dcterms.referencesF. Di Nardo, S. Cavalera, C. Baggiani, C. Giovannoli, and L. Anfossi, “Direct vs Mediated Coupling of Antibodies to Gold Nanoparticles: The Case of Salivary Cortisol Detection by Lateral Flow Immunoassay,” ACS Appl Mater Interfaces, vol. 11, no. 36, pp. 32758–32768, Sep. 2019, doi: 10.1021/acsami.9b11559.eng
dcterms.referencesK. Chauhan, P. Singh, and R. K. Singhal, “New Chitosan-Thiomer: An Efficient Colorimetric Sensor and Effective Sorbent for Mercury at Ultralow Concentration,” ACS Appl Mater Interfaces, vol. 7, no. 47, pp. 26069–26078, Dec. 2015, doi: 10.1021/acsami.5b06078eng
dcterms.referencesD. S. and D. M. Volker Thomsen, “Limits of Detection in Spectroscopy,” Spectroscopy, vol. 18, pp. 112–114, 2003.eng
dcterms.referencesA. S. Naik et al., “Podocyte stress and detachment measured in urine are related to mean arterial pressure in healthy humans,” Kidney Int, vol. 98, no. 3, pp. 699–707, Sep. 2020, doi: 10.1016/j.kint.2020.03.038.eng
dcterms.referencesS. H. Kwon et al., “Elevated urinary podocyte-derived extracellular microvesicles in renovascular hypertensive patients,” Nephrology Dialysis Transplantation, vol. 32, no. 5, pp. 800–807, May 2017, doi: 10.1093/ndt/gfw077.eng
dcterms.referencesI. M. Craici et al., “Podocyturia Predates Proteinuria and Clinical Features of Preeclampsia Longitudinal Prospective Study,” 2013, doi: 10.1161/HYPERTENSIONAHA.eng
dcterms.referencesS. I. Gilani et al., “Urinary extracellular vesicles of podocyte origin and renal injury in preeclampsia,” Journal of the American Society of Nephrology, vol. 28, no. 11, pp. 3363–3372, Nov. 2017, doi: 10.1681/ASN.2016111202.eng
dcterms.referencesM. Larraona-Puy et al., “Development of Raman microspectroscopy for automated detection and imaging of basal cell carcinoma,” J Biomed Opt, vol. 14, no. 5, p. 054031, 2009, doi: 10.1117/1.3251053eng
dcterms.referencesF. B. Roberto et al., “Podocyturia in pregnant women with chronic hypertension may predict kidney injury?,” Revista Brasileira de Ginecologia e Obstetricia, vol. 37, no. 4, pp. 172–177, Jun. 2015, doi: 10.1590/SO100-720320150005238.eng
dcterms.referencesM. Y. Yu et al., “Krüppel-like factor 15 is a key suppressor of podocyte fibrosis under rotational force-driven pressure,” Exp Cell Res, vol. 386, no. 1, Jan. 2020, doi: 10.1016/j.yexcr.2019.111706.eng
dcterms.referencesV. D. Garovic et al., “Urinary podocyte excretion as a marker for preeclampsia,” Am J Obstet Gynecol, vol. 196, no. 4, pp. 320.e1-320.e7, 2007, doi: 10.1016/j.ajog.2007.02.007eng
dcterms.references“Quantitative Polymerase Chain Reaction–Based Analysis of Podocyturia Is a Feasible Diagnostic Tool in Preeclampsia,” 2012, doi: 10.1161/HYPERTENSIONAHA.eng
dcterms.referencesV. D. Garovic et al., “Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia,” Nephrology Dialysis Transplantation, vol. 22, no. 4, pp. 1136–1143, Apr. 2007, doi: 10.1093/ndt/gfl711eng
dcterms.referencesT. Zhai et al., “Alteration of podocyte phenotype in the urine of women with preeclampsia,” Sci Rep, vol. 6, Apr. 2016, doi: 10.1038/srep24258.eng
dcterms.referencesG. Chen, X. Jin, L. Zhang, J. Niu, and Y. Gu, “Decreased Ang-(1-7) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia,” Reproductive Sciences, vol. 26, no. 8, pp. 1146– 1157, Aug. 2019, doi: 10.1177/1933719118813200.eng
dcterms.referencesY. Wang, Y. Gu, S. Loyd, X. Jia, L. J. Groome, and Y. Wang, “Increased urinary levels of podocyte glycoproteins, matrix metallopeptidases, inflammatory cytokines, and kidney injury biomarkers in women with preeclampsia,” Am J Physiol Renal Physiol, vol. 309, pp. 1009–1017, 2015, doi: 10.1152/ajprenal.00257.2015.-Toeng
dcterms.referencesY. Wang, S. Zhao, S. Loyd, and L. J. Groome, “Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsia,” Am J Physiol Renal Physiol, vol. 302, no. 9, 2012, doi: 10.1152/ajprenal.00597.2011.eng
dcterms.referencesG. Wang et al., “Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis,” Am J Hypertens, vol. 23, no. 1, pp. 78–84, Jan. 2010, doi: 10.1038/ajh.2009.208eng
dcterms.referencesW. P. H. O. L. N. C. S. J. Z. and R. P. V. D. Jeffrey N. Anker, “Biosensing with plasmonic nanosensors,” Nat Mater, vol. 7, pp. 442–453, Jun. 2008, doi: 10.1038/nmat2162.eng
dcterms.referencesJ. M. Surmacki, B. J. Woodhams, A. Haslehurst, B. A. J. Ponder, and S. E. Bohndiek, “Raman micro-spectroscopy for accurate identification of primary human bronchial epithelial cells,” Sci Rep, vol. 8, no. 1, Dec. 2018, doi: 10.1038/s41598- 018-30407-8.eng
dcterms.referencesP. Banerjee et al., “Identification of key contributory factors responsible for vascular dysfunction in idiopathic recurrent spontaneous miscarriage,” PLoS One, vol. 8, no. 11, Nov. 2013, doi: 10.1371/journal.pone.0080940eng
dcterms.references“Raman Spectroscopy of Biological Tissues _ Enhanced Reader”.eng
dcterms.referencesL. P. Moreira, L. Silveira, A. G. da Silva, A. B. Fernandes, M. T. T. Pacheco, and D. D. F. M. Rocco, “Raman spectroscopy applied to identify metabolites in urine of physically active subjects,” J Photochem Photobiol B, vol. 176, pp. 92–99, Nov. 2017, doi: 10.1016/j.jphotobiol.2017.09.019eng
dcterms.referencesO. M. Primera-Pedrozo, J. I. Jerez-Rozo, E. De La Cruz-Montoya, T. Luna-Pineda, L. C. Pacheco-Londoño, and S. P. Hernández-Rivera, “Nanotechnology-based detection of explosives and biological agents simulants,” IEEE Sens J, vol. 8, no. 6, pp. 963–973, Jun. 2008, doi: 10.1109/JSEN.2008.923936eng
dcterms.referencesJ. Li et al., “Raman spectroscopy as a diagnostic tool for monitoring acute nephritis,” J Biophotonics, vol. 9, no. 3, pp. 260–269, Mar. 2016, doi: 10.1002/jbio.201500109.eng
dcterms.referencesR. Pappu, A. Prakasarao, K. Dornadula, and G. Singaravelu, “Raman spectroscopic characterization of urine of normal and cervical cancer subjects,” in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, SPIE, Feb. 2017, p. 1005404. doi: 10.1117/12.2255878.eng
dcterms.referencesQ. Zhou et al., “Epigenetic analysis of cell-free DNA by fragmentomic profiling,” 2022, doi: 10.1073/pnas.eng
dcterms.referencesE. D. C. Zarate-Peñata, O. Fiorillo-Moreno, C. Meza-Torres, and E. NavarroQuiroz, “Cytokines, Chemokines, Inflammasomes, Myokines and ComplementRelated Factors in Acute Kidney Injury,” in Organ Crosstalk in Acute Kidney Injury, 2023. doi: 10.1007/978-3-031-36789-2_5.eng
dcterms.referencesE. D. C. Zarate-Peñata et al., “Genetic, Epigenetics, and Cell Adhesion in Acute Kidney Injury,” in Organ Crosstalk in Acute Kidney Injury, 2023. doi: 10.1007/978- 3-031-36789-2_6.eng
dcterms.referencesE. Navarro-Quiroz et al., “High-throughput sequencing reveals circulating miRNAs as potential biomarkers of kidney damage in patients with systemic lupus erythematosus,” PLoS One, vol. 11, no. 11, Nov. 2016, doi: 10.1371/journal.pone.0166202.eng
dcterms.referencesM. Kuwabara et al., “Update in uric acid, hypertension, and cardiovascular diseases,” Hypertension Research, vol. 46, no. 7. 2023. doi: 10.1038/s41440-023- 01273-3eng
dcterms.referencesJ. Ortmann et al., “Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition,” Hypertension, vol. 44, no. 6, pp. 974–981, Dec. 2004, doi: 10.1161/01.HYP.0000149249.09147.b4.eng
dcterms.referencesS. Shibata, M. Nagase, S. Yoshida, H. Kawachi, and T. Fujita, “Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1,” Hypertension, vol. 49, no. 2, pp. 355–364, Feb. 2007, doi: 10.1161/01.HYP.0000255636.11931.a2eng
dcterms.referencesO. D. Navarro-Ulloa et al., “Usefulness of 24-hour ambulatory blood pressure monitoring in a population with high cardiovascular risk,” Cirugia y Cirujanos (English Edition), vol. 88, no. 5, pp. 617–623, 2020, doi: 10.24875/CIRU.20001576.eng
dcterms.referencesS. Martin, “Daño renal agudo en niños críticos: incidencia y factores de riesgo de mortalidad,” Arch Argent Pediatr, vol. 111, no. 5, pp. 412–417, Oct. 2013, doi: 10.5546/aap.2013.412.spa
dcterms.referencesJ. S. Chávez-Iñiguez et al., “Procalcitonina como biomarcador de daño renal agudo en pacientes con sepsis y choque séptico,” Revista Colombiana de Nefrología, vol. 6, no. 2, pp. 130–137, Nov. 2019, doi: 10.22265/acnef.6.2.351.spa
dcterms.referencesA. Jara and S. Mezzano, “Daño vascular en la enfermedad renal crónica,” Revista medica Chilena, vol. 136, pp. 1476–1484, May 2008spa
dcterms.referencesS. A. Vetrone et al., “Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β,” Journal of Clinical Investigation, vol. 119, no. 6, pp. 1583–1594, Jun. 2009, doi: 10.1172/JCI37662.eng
dcterms.referencesJ. Rangaswami et al., “Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association,” Circulation, vol. 139, no. 16, pp. E840–E878, Apr. 2019, doi: 10.1161/CIR.0000000000000664.eng
dcterms.referencesC. R. Parikh et al., “Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery,” Journal of the American Society of Nephrology, vol. 22, no. 9, pp. 1748–1757, Sep. 2011, doi: 10.1681/ASN.2010121302.eng
dcterms.referencesM. Walters et al., “Serum Uric Acid Level, Longitudinal Blood Pressure, Renal Function, and Long-Term Mortality in Treated Hypertensive Patients,” Hypertension, vol. 62, pp. 105–111, 2013, doi: 10.1161/HYPERTENSIONAHAeng
dcterms.referencesA. O. Oluboyo, “EVALUATION OF SELECTED RENAL MARKERS IN HYPERTENSIVE SUBJECTS IN EKITI STATE, NIGERIA,” 2020. [Online]. Available: www.ijmlr.com/IJMLR©Allrightarereservedeng
dcterms.referencesL. M. E. D. F. Xiaoyan Zhou, “Uric Acid: Its Relationship to Renal Hemodynamics and the Renal Renin-Angiotensin System,” Hypertension and Metabolic Disarray, no. 1522–6417, pp. 120–124, 2006.eng
dcterms.referencesM. Trudu et al., “Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression,” Nat Med, vol. 19, no. 12, pp. 1655–1660, Dec. 2013, doi: 10.1038/nm.3384eng
dcterms.referencesY. Shamoo, L. R. Ghosaini, K. M. Keating, K. R. Williams, J. M. Sturtevant, and W. H. Konigsberg, “Site-Specific Mutagenesis of T4 Gene 32: The Role of Tyrosine Residues in ProteineNucleic Acid Interactionst,” 1989.eng
dcterms.referencesM. E. Cogswell et al., “Validity of predictive equations for 24-H urinary sodium excretion in adults aged 18-39 y1-5,” American Journal of Clinical Nutrition, vol. 98, no. 6, pp. 1502–1513, Dec. 2013, doi: 10.3945/ajcn.113.059436.eng
oaire.versioninfo:eu-repo/semantics/acceptedVersioneng
sb.programaDoctorado en Genética y Biología Molecularspa
sb.sedeSede Barranquillaspa

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