Registro Colombiano de Enfermedades Glomerulares (Reglocol): informe preliminar
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Fecha
2025
Autores
Aroca-Martinez, Gustavo
Figueroa Millán , Christian Camilo
Daza, Jose Lucas
Cadena Bonfanti, Andres Angélo
Pérez Jiménez, Valentina
LASSO LATORRE, KAREN GISELLE
Torres Saltarín, Jaime José
Cotes Araujo, Luis Andrés
Puche Carrascal, Eduardo
Hernandez Agudelo, Sandra
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Asociación Colombiana de Nefrología e Hipertensión Arterial
Resumen
Contexto: las enfermedades glomerulares son una causa relevante de morbilidad renal y se
clasifican en primarias y secundarias. En América Latina predominan las formas secundarias
asociadas a lupus. En Colombia, el Registro REGLOCOL busca caracterizar su perfil clínico,
histológico y terapéutico para fortalecer la investigación en nefrología.
Objetivo: describir las características demográficas, clínicas e histopatológicas de los pacientes
incluidos en la fase preliminar del Registro Colombiano de Enfermedades Glomerulares
(Reglocol).
Métodos: se realizó un estudio descriptivo de corte transversal que analizó 900 reportes de
biopsia renal procedentes de 11 centros de nefrología en Colombia, recolectados entre 2010 y
2025. Se obtuvieron variables demográficas, clínicas e histopatológicas a partir de formularios
estandarizados. Se aplicó estadística descriptiva y los resultados se expresaron en frecuencias,
medias y medianas con rangos intercuartílicos.
Resultados: de las 900 biopsias revisadas, 864 cumplieron criterios de inclusión. Las glomerulopatías
primarias representaron el 70,7 % de los casos, mientras que las secundarias constituyeron
el 29,3 %. Los diagnósticos más frecuentes fueron nefritis lúpica (22,8 %), glomeruloesclerosis
focal y segmentaria (22,1 %), glomerulonefritis membranoproliferativa (14,1 % y nefropatía por
inmunoglobulina A (IgA) (12,0 %). Se observó predominio del sexo femenino (56,8 %), etnia mestiza
(88,5 %) y edades entre 30 y 59 años (42,4 %). El síndrome nefrótico (39,8 %) y la hipertensión
arterial (35,3 %) fueron las presentaciones clínicas más comunes. La mayor concentración de
casos se registró en la región Caribe, correspondiente a los centros participantes.
Conclusiones: los hallazgos preliminares del Reglocol evidenciaron que las glomerulopatías en
Colombia afectan predominantemente a mujeres en edad productiva, siendo la nefritis lúpica y
la glomeruloesclerosis focal y segmentaria las entidades más prevalentes. Reglocol representa
un avance significativo en la caracterización nacional de las enfermedades glomerulares y
constituye la base para futuros estudios multicéntricos sobre determinantes epidemiológicos,
genéticos y ambientales de la enfermedad renal en América Latina.
Background: Glomerular diseases are a significant cause of renal morbidity and are classified as primary or secondary. In Latin America, secondary forms associated with lupus are predominant. In Colombia, the REGLOCOL Registry aims to characterize their clinical, histological, and therapeutic profiles to strengthen nephrology research. Objective: To describe the demographic, clinical, and histopathological characteristics of patients included in the preliminary phase of the Colombian Registry of Glomerular Diseases (REGLOCOL). Methods: A descriptive cross-sectional analysis of 900 biopsy reports from 11 nephrology centers across Colombia was conducted between 2010 and 2025. Clinical, demographic, and histopathological data were extracted from standardized forms. Descriptive statistics were used to summarize the data, which are presented as frequencies, means, and medians with interquartile ranges. Results: Of the 900 biopsies reviewed, 864 met inclusion criteria. Primary glomerulopathies accounted for 70.7 % of cases, while secondary forms represented 29.3 %. The most frequent diagnoses were lupus nephritis (22.8 %), focal and segmental glomerulosclerosis (22.1 %), membranoproliferative glomerulonephritis (14.1 %), and IgA nephropathy (12 %). The cohort was predominantly female (56.8 %), of mestizo ethnicity (88.5 %), and aged 30-59 years (42.4 %). The most common clinical presentation was nephrotic syndrome (39.8 %), followed by arterial hypertension (35.3 %). Regional distribution revealed a higher concentration of cases in the Caribbean region, which corresponded to the larger number of participating centers located in that region. Conclusions: Preliminary findings from REGLOCOL reveal that glomerular diseases in Colombia predominantly affect women of productive age, with lupus nephritis and focal and segmental glomerulosclerosis as the leading entities. REGLOCOL represents a milestone in the national characterization of glomerular pathology and establishes a foundation for future multicenter studies aimed at understanding epidemiological, genetic, and environmental determinants of kidney disease in Latin America.
Background: Glomerular diseases are a significant cause of renal morbidity and are classified as primary or secondary. In Latin America, secondary forms associated with lupus are predominant. In Colombia, the REGLOCOL Registry aims to characterize their clinical, histological, and therapeutic profiles to strengthen nephrology research. Objective: To describe the demographic, clinical, and histopathological characteristics of patients included in the preliminary phase of the Colombian Registry of Glomerular Diseases (REGLOCOL). Methods: A descriptive cross-sectional analysis of 900 biopsy reports from 11 nephrology centers across Colombia was conducted between 2010 and 2025. Clinical, demographic, and histopathological data were extracted from standardized forms. Descriptive statistics were used to summarize the data, which are presented as frequencies, means, and medians with interquartile ranges. Results: Of the 900 biopsies reviewed, 864 met inclusion criteria. Primary glomerulopathies accounted for 70.7 % of cases, while secondary forms represented 29.3 %. The most frequent diagnoses were lupus nephritis (22.8 %), focal and segmental glomerulosclerosis (22.1 %), membranoproliferative glomerulonephritis (14.1 %), and IgA nephropathy (12 %). The cohort was predominantly female (56.8 %), of mestizo ethnicity (88.5 %), and aged 30-59 years (42.4 %). The most common clinical presentation was nephrotic syndrome (39.8 %), followed by arterial hypertension (35.3 %). Regional distribution revealed a higher concentration of cases in the Caribbean region, which corresponded to the larger number of participating centers located in that region. Conclusions: Preliminary findings from REGLOCOL reveal that glomerular diseases in Colombia predominantly affect women of productive age, with lupus nephritis and focal and segmental glomerulosclerosis as the leading entities. REGLOCOL represents a milestone in the national characterization of glomerular pathology and establishes a foundation for future multicenter studies aimed at understanding epidemiological, genetic, and environmental determinants of kidney disease in Latin America.
Descripción
Palabras clave
Glomerulopatías, Nefritis lúpica, Glomeruloesclerosis focal y segmentaria, Biopsia renal, Epidemiología
Citación
Aroca Martínez G, Figueroa Millan C, Daza JL, Cadena Bonfanti A, Pérez Jiménez V, Lasso Latorre K, et al. Registro Colombiano de Enfermedades Glomerulares (Reglocol): informe preliminar. Rev. Colomb. Nefrol. 2025; 12(3), e1065. https://doi.org/10.22265/acnef.12.3.1065
