Alteraciones de la función hepática en los pacientes infectados por covid-19 remitidos a UCI en el año 2020 a través del SCORE MELD en una institución prestadora de servicios en salud de Barranquilla (At, Co)
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Fecha
2021
Autores
Tirado Romero, Gloria Ibis
Moran Marín, Leinad Yamile
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Ediciones Universidad Simón Bolivar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
La infección por SARS COV2/ COVID 2019, es una enfermedad cuya sintomatología común es fiebre, tos, dolor de garganta, cefalea, disnea, mialgias, náuseas, vómitos, diarreas, dolor abdominal y pérdida del apetito. Se ha observado, que a pesar del gran compromiso pulmonar, las alteraciones hepáticas, también se deben considerar, asociandose a las formas más graves y a mayor mortalidad.
OBJETIVO: Caracterizar las alteraciones en la bioquímica hepática en una cohorte de pacientes con Covid-19 del año 2020 en una Institución Prestadora de Servicios en Salud de Barranquilla (At, Co).
METODOLOGÍA: Se realizò un diseño retrospectivo, longitudinal, con profundidad analítica y un carácter de medida cuantitativo, en 754 pacientes mayores de edad ingresados a una unidad de cuidados intensivos con prueba RT-PCR positiva durante el año 2020. Se creó una base de datos provenientes de las historias clínicas de estos.
RESULTADOS: Al evaluar pacientes con COVID-19, con el MELD Score, el valor promedio global fue de 7.07±7.62 y con una mediana 5.49. Para los sobrevivientes el valor promedio de 5.37±7.52 y una mediana de 4.29, mientras que de los fallecidos fue de 9.45±7.22 con una mediana de 8.02 [RIC 4.35 – 14.24], estos resultados indican la asociación entre un Score alto para MELD y un desenlace fatal.
CONCLUSION: En este estudio se observò que los marcadores inflamatorios en los pacientes con Covid-19 con bioquímica hepática anormal, evaluados a través de la escala Model for End-Stage Liver Disease constituyen un elemento de importancia para predecir la respuesta de los pacientes infectados con Covid-19.
SARS COV2 / COVID 2019 infection is a disease whose common symptoms are fever, cough, sore throat, headache, dyspnea, myalgia, nausea, vomiting, diarrhea, abdominal pain and loss of appetite. It has been observed that despite the great pulmonary involvement, liver alterations should also be considered, associated with the most severe forms and with higher mortality. OBJECTIVE: To characterize the alterations in liver biochemistry in a cohort of patients with Covid-19 from 2020 in a Health Service Provider Institution of Barranquilla (At, Co). METHODOLOGY: A retrospective, longitudinal design was carried out, with analytical depth and a quantitative measurement character, in 754 patients of legal age admitted to an intensive care unit with a positive RT-PCR test during 2020. A database was created from their medical records. RESULTS: When evaluating patients with COVID-19, with the MELD Score, the global mean value was 7.07 ± 7.62 and with a median 5.49. For the survivors, the mean value of 5.37 ± 7.52 and a median of 4.29, while for the deceased it was 9.45 ± 7.22 with a median of 8.02 [IQR 4.35 - 14.24], these results indicate the association between a high Score for MELD and a fatal outcome. CONCLUSION: In this study it was observed that inflammatory markers in patients with Covid-19 with abnormal liver biochemistry, evaluated through the Model for End-Stage Liver Disease scale, constitute an important element to predict the response of patients infected with Covid-19.
SARS COV2 / COVID 2019 infection is a disease whose common symptoms are fever, cough, sore throat, headache, dyspnea, myalgia, nausea, vomiting, diarrhea, abdominal pain and loss of appetite. It has been observed that despite the great pulmonary involvement, liver alterations should also be considered, associated with the most severe forms and with higher mortality. OBJECTIVE: To characterize the alterations in liver biochemistry in a cohort of patients with Covid-19 from 2020 in a Health Service Provider Institution of Barranquilla (At, Co). METHODOLOGY: A retrospective, longitudinal design was carried out, with analytical depth and a quantitative measurement character, in 754 patients of legal age admitted to an intensive care unit with a positive RT-PCR test during 2020. A database was created from their medical records. RESULTS: When evaluating patients with COVID-19, with the MELD Score, the global mean value was 7.07 ± 7.62 and with a median 5.49. For the survivors, the mean value of 5.37 ± 7.52 and a median of 4.29, while for the deceased it was 9.45 ± 7.22 with a median of 8.02 [IQR 4.35 - 14.24], these results indicate the association between a high Score for MELD and a fatal outcome. CONCLUSION: In this study it was observed that inflammatory markers in patients with Covid-19 with abnormal liver biochemistry, evaluated through the Model for End-Stage Liver Disease scale, constitute an important element to predict the response of patients infected with Covid-19.
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COVID-19, MELD Score, Alteraciones en la bioquímica hepática, Unidad de cuidados intensivos, COVID-19, MELD Score, Alterations in liver biochemistry, Intensive care unit