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dc.contributor.authorSalazar, Juan
dc.contributor.authorAngarita, Lissé
dc.contributor.authorMorillo, Valery
dc.contributor.authorNavarro, Carla
dc.contributor.authorMartínez, María Sofía
dc.contributor.authorChacín, Maricarmen
dc.contributor.authorTorres, Wheeler
dc.contributor.authorRajotia, Arush
dc.contributor.authorRojas, Milagros
dc.contributor.authorCano, Clímaco
dc.contributor.authorAñez, Roberto
dc.contributor.authorRojas, Joselyn
dc.contributor.authorBermúdez, Valmore
dc.date.accessioned2021-01-20T23:07:35Z
dc.date.available2021-01-20T23:07:35Z
dc.date.issued2020
dc.identifier.issn20726643
dc.identifier.urihttps://hdl.handle.net/20.500.12442/7003
dc.description.abstractDiabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a state of insulin resistance and hyperglycemia is present. Conversely, during eubiosis, the production of short-chain fatty acids (SCFA) is fundamental for the maintenance of the integrity of the intestinal barrier as well as for immunogenic tolerance and appetite/satiety perception, leading to a protective effect. Additionally, it has been demonstrated that alterations or dysregulation of the gut microbiota can be reversed by modifying the eating habits of the patients or with the administration of prebiotics, probiotics, and symbiotics. Similarly, different studies have demonstrated that drugs like Metformin are capable of modifying the composition of the gut microbiota, promoting changes in the biosynthesis of LPS, and the metabolism of SCFA.eng
dc.format.mimetypepdfspa
dc.language.isoengeng
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceNutrientseng
dc.sourceVol. 12, No. 10, 2020
dc.subjectDiabetesspa
dc.subjectInflammationeng
dc.subjectMicrobiotaeng
dc.subjectDysbiosiseng
dc.subjectLipopolysaccharideseng
dc.subjectShort-chaineng
dc.subjectFatty acidseng
dc.titleMicrobiota and Diabetes Mellitus: Role of Lipid Mediatorseng
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dc.identifier.doihttps://doi.org/10.3390/nu12103039
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