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dc.contributor.authorLeón-Mejía, Grethel
dc.contributor.authorQuintana-Sosa, Milton
dc.contributor.authorde Moya Hernandez, Yurina
dc.contributor.authorLuna Rodríguez, Ibeth
dc.contributor.authorTrindade, Cristiano
dc.contributor.authorAnaya Romero, Marco
dc.contributor.authorLuna-Carrasca, Jaime
dc.contributor.authorOliveros Ortíz, Ludis
dc.contributor.authorAcosta-Hoyos, Antonio
dc.contributor.authorRuiz-Benitez, Martha
dc.contributor.authorFranco Valencia, Karen
dc.contributor.authorRohr, Paula
dc.contributor.authorda Silva, Juliana
dc.contributor.authorPêgas Henriques, João Antônio
dc.date.accessioned2020-04-06T20:58:15Z
dc.date.available2020-04-06T20:58:15Z
dc.date.issued2020-03
dc.identifier.issn09441344spa
dc.identifier.urihttps://hdl.handle.net/20.500.12442/5090
dc.description.abstractDiesel engine exhaust (DEE) is a complex mixture of toxic gases, halogenated aromatic hydrocarbons, alkyl polycyclic aromatic hydrocarbons, polycyclic aromatic hydrocarbons, benzene derivatives, metals and diesel exhaust particles (DEPs) generated from the incomplete combustion of diesel fuel. Many of the compounds in this mixture can cause oxidative damage to DNA and are considered carcinogenic for humans. Further, chronic DEE exposure increases risks of cardiovascular and pulmonary diseases. Despite these pervasive health risks, there is limited and inconsistent information regarding genetic factors conferring susceptibility or resistance to DEE genotoxicity. The present study evaluated the effects of polymorphisms in two base excision repair (BER) genes (OGG1 Ser326Cys and XRCC1 Arg280His), one homologous recombination (HRR) gene (XRCC3 Thr241Met) and two xenobiotic metabolism genes (GSTM1 and GSTT1) on the genotoxicity profiles among 123 mechanics exposed to workplace DEE. Polymorphisms were determined by PCR-RFLP. In comet assay, individuals with the GSTT1 null genotype demonstrated significantly greater % tail DNA in lymphocytes than those with non-null genotype. In contrast, these null individuals exhibited significantly lower frequencies of binucleated (BN) cells and nuclear buds (NBUDs) in buccal cells than non-null individuals. Heterozygous hOGG1 326 individuals (hOGG1 326 Ser/Cys) exhibited higher buccal cell NBUD frequency than hOGG1 326 Ser/Ser individuals. Individuals carrying the XRCC3 241 Met/Met polymorphism also showed significantly higher buccal cell NBUD frequencies than those carrying the XRCC3 241 Thr/Thr polymorphism. We found a high flow of particulate matter with a diameter of < 2.5 μm (PM2.5) in the workplace. The most abundant metals in DEPs were iron, copper, silicon and manganese as detected by transmission electron microscopy–energy-dispersive X-ray spectroscopy (TEM-EDX). Scanning electron microscopy (SEM-EDS) revealed particles with diameters smaller than PM2.5, including nanoparticles forming aggregates and agglomerates. Our results demonstrate the genotoxic effects of DEE and the critical influence of genetic susceptibility conferred by DNA repair and metabolic gene polymorphisms that shed light into the understanding of underlying mechanisms.spa
dc.format.mimetypepdfspa
dc.publisherSpringerspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceEnvironmental Science and Pollution Researchen
dc.source(2020)spa
dc.subjectDiesel exhaust particlesspa
dc.subjectPolymorphismspa
dc.subjectDNA repairspa
dc.subjectDNA oxidative damagespa
dc.subjectMechanicsspa
dc.titleDNA repair and metabolic gene polymorphisms affect genetic damage due to diesel engine exhaust exposureen
dc.typearticleen
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dc.identifier.doiDOI 10.1007/s11356-020-08533-6


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