Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
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Fecha
2019
Autores
Trindade, Cristiano
Mendes Juchem, André Luiz
Guecheva, Temenouga N.
Oliveira, Iuri M. de
dos Santos Silveira, Priscila
Vargas, José Eduardo
Puga, Renato
Pessoa, Claudia Ó.
Henriques, João A. P.
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Editor
Hindawi
Resumen
Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established.
In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading
to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant,
antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and
depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may
exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes:
transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis
pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and
safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell
lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.