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dc.contributor.authorSánchez, María Patricia
dc.contributor.authorPrieto, Carem
dc.contributor.authorMujica, Endrina
dc.contributor.authorVergara, Kendry
dc.contributor.authorValencia, Enifer
dc.contributor.authorVillalobos, Eudymar
dc.contributor.authorMedina, Mayerlim
dc.contributor.authorParra, Michael
dc.contributor.authorD'Addosio, Rosanna
dc.contributor.authorHoedebecke, Kyle
dc.contributor.authorRodríguez, Johel E.
dc.contributor.authorBermudez, Valmore
dc.date.accessioned2019-07-18T13:41:38Z
dc.date.available2019-07-18T13:41:38Z
dc.date.issued2019
dc.identifier.issn20461402
dc.identifier.urihttps://hdl.handle.net/20.500.12442/3568
dc.description.abstractBackground: Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the ADIPOQ gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the ADIPOQ gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela. Methods: A total of 90 subjects who attended the Center for Metabolic Endocrine Research "Dr. Félix Gómez" were enrolled for this study, 46 of which had MS-DM2 and 44 of which were healthy control individuals. Genomic DNA was extracted from blood samples and PCR-restriction fragment length polymorphism analysis was carried out for the promoter region of the ADIPOQ gene. Likewise, the +45 T> G polymorphism was identified and correlated with MS and DM2 in the studied population. Results: The most frequent allele in both groups was the T allele, and the predominant genotype was homozygous T/T (79%). Genotypes with heterozygous T/G and G/G homozygous polymorphism were more frequent in the control group than in the MS-DM2 group. Regarding the individuals with T/G and G/G genotypes, statistically significant lower mean values were found for fasting glucose, total cholesterol, triacylglycerides, abdominal circumference, and for the medians of systolic and diastolic blood pressure. Odds ratio were calculated for the presence or absence of MS and DM2. Conclusions: The results suggested that the presence of the G allele exerts a protective effect on the carrier individuals, thus avoiding the appearance of the aforementioned metabolic alterations.eng
dc.language.isoengeng
dc.publisherF1000 Research Ltdaeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceRevista F1000 Researcheng
dc.sourceVol. 8 No. 292 (2019)spa
dc.source.urihttps://doi.org/10.12688/f1000research.16890.1eng
dc.subjectMetabolic syndromeeng
dc.subjectType 2 diabetes mellituseng
dc.subjectADIPOQ geneeng
dc.subjectPolymorphismseng
dc.subjectDNAeng
dc.titleAssociation between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population [version 1; peer review: 2 approved, 1 approved with reservations]eng
dc.typearticleeng
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