Cell Signaling in Neuronal Stem Cells
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Fecha
2018-07
Autores
Navarro Quiroz, Elkin
Navarro Quiroz, Roberto
Ahmad, Mostapha
Gomez Escorcia, Lorena
Villarreal, Jose Luis
Fernandez Ponce, Cecilia
Aroca Martinez, Gustavo
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Editor
MDPI
Resumen
The defining characteristic of neural stem cells (NSCs) is their ability to multiply through
symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise
to different types of cells of the central nervous system (CNS). A strict temporal space control of the
NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions
and, in some cases, death. This work reviews the current state of the molecular mechanisms that
regulate the transcription in NSCs, organized according to whether the origin of the stimulus that
triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of
the microenvironment that surrounds the CNS (extrinsic factors).
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Palabras clave
Neural stem cell, Wnt/beta-Catenin, Differentiation