Analysis of Gene Polymorphism CYP2C19 in the Lebanese Population Who Reside in Colombia
No hay miniatura disponible
Fecha
2018-06
Autores
Ahmad, Mostapha
Navarro-Quiroz, Elkin
García Moreno, Angélica Margarita
Rios Anillo, Margarita Rosa
Silvera Redondo, Carlos Arturo
Fernandez Ponce, Cecilia
Título de la revista
ISSN de la revista
Título del volumen
Editor
Canadian Center of Science and Education
Resumen
Background: The aim of this study is to determine the polymorphism of the CYP2C19 gene in the Lebanese
population living in Colombia due to the lack of information and the importance of establishing its behavior which
can predict a diminished or increased metabolism of medication related to it.
Methods and Results: 109 Lebanese volunteers residents of Colombia were included, genotypes for the
CYP2C19 were detected by polymerase Chain Reaction-PCR finding that the most frequent allele was *1 (73.4%),
followed by *2 (26.6%) the allele *3 was not found in the studied population. Only fast metabolites were found
because of the *1/*1 (73.4%) and *1/*2 (26.6%) genotypes, any *1/*3, *2/*2 or *3/*3 genotype were found.
Conclusions: The results obtained show a similar behavior with the alleles frequencies of the previous studies
made in Colombia, Africa, Europe and other American population. Knowing the genotype of the population is
important for the selection and adjustment of the doses of the best medication to give the optimal treatment in
medical practice. The pharmacogenetics will reduce the adverse reactions during medical treatment for a better and
more accurate clinical approach.
Descripción
Palabras clave
CYP2C19, Polymorphism, Lebanese, Pharmacogenetics