Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study
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Fecha
2017-06
Autores
Gunawardene, Piumali
Al Saedi, Ahmed
Singh, Lakshman
Bermeo, Sandra
Vogrin, Sara
Phu, Steven
Suriyaarachchi, Pushpa
Pignolo, Robert J.
Duque, Gustavo
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Editor
Elsevier
Resumen
Circulating osteoprogenitor (COP) cells are blood-borne cellswhich express a variety of osteoblasticmarkers and
are able to formbone nodules in vivo.Whereas a high percentage of COP cells (%COP) is associatedwith vascular
calcification, low %COP has been associated with disability and frailty. However, the reference range of %COP in
age- and gender-matching populations, and the age-related changes in %COP remain unknown. A cross-sectional
studywas undertaken in 144 healthy volunteers inWestern Sydney (20–90 year-old, 10male and 10 female subjects
per decade). %COP was quantified by flow cytometry. A high inter-and intra-rater reliability was found. In
average, in this healthy population average of %COP was 0.42. There was no significant difference in %COP
among the age groups. Similarly, no significant difference was found in %COP with gender, weight, height or
BMI. In addition, we identified a normal reference range of %COP of 0.1–3.8%. In conclusion, in addition to the
identification of steady levels of COP cells with age, we also identified a normal reference range of %COP,
which could be used in future studies looking at musculoskeletal diseases in older populations.
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Palabras clave
Osteosarcopenia, Stem cells, Musculoskeletal, Circulating osteoprogenitors