Ortega, ÁngelVera, IvanaDiaz, Maria P.Navarro, CarlaRojas, MilagrosTorres, WheelerParra, HelianaSalazar, JuanDe Sanctis, Juan B.Bermúdez, Valmore2022-04-012022-04-012022Ortega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms2301043014220067https://hdl.handle.net/20.500.12442/9506The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.pdfengAttribution-NonCommercial-NoDerivatives 4.0 InternacionalYAP/TAZHippo signaling pathwaycarcinogenesisTumor microenvironmentneoplastic stem cellscell proliferationdrug resistancechemoresistanceimmunotherapyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://doi.org/10.3390/ijms23010430