Navarro Quiroz, ElkinChavez-Estrada, ValeriaMacias-Ochoa, KarimeAyala-Navarro, María FernandaFlores-Aguilar, Aniyensy SaraiMorales-Navarrete, FranciscoDe la Cruz Lopez, FernandoGomez Escorcia, LorenaG. Musso, CarlosAroca Martinez, GustavoGonzales Torres, HenryDiaz Perez, AndersonCadena Bonfanti, AndresSarmiento Gutierrez, JoanyMeza, JainyDiaz Arroyo, EsperanzaBello Lemus, YesitAhmad, MostaphaNavarro Quiroz, Roberto2019-11-132019-11-13201914220067https://hdl.handle.net/20.500.12442/4335The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.engAttribution-NonCommercial-NoDerivatives 4.0 InternacionalPosttranslational modificationsEpigenetic mechanismsSystemic lupus erythematosusUbiquitinationSUMOylationGlycosylationHydroxylationPhosphorylationSulfationAcetylationarticleinfo:eu-repo/semantics/openAccess