Dulce Muñoz, Jaime ArturoAroca-Martinez, GustavoSeni, ChristianPerea Rojas, Diana MarcelaCABARCAS BARBOSA, OMARNiño Hernández, Lucia MercedesGaivao Arciniegas, Dario JoseGarcía Jarava, Camila MariaOlivares Olmos, MarianelaSeni Hernandez, Sebastian AndrePérez Jiménez, ValentinaRojas-Torres, Indiana-Luz2025-03-052025-03-05202520906641 (Impreso)2090665X (Electrónico)https://hdl.handle.net/20.500.12442/16340Systemic lupus erythematosus is a systemic autoimmune pathology that generally presents in young people and manifests acutely, while its late presentation in people over 50 years of age is rare and insidious. Vasculitis is a pathology that afects any vessel producing fbrinoid necrosis, and presents with a positive antineutrophil cytoplasmic antibody. Te concomitance of these two entities is rare and leads to worse clinical outcomes. We present a 73-year-old female patient who presented with rapidly progressive glomerulonephritis requiring renal replacement therapy, pulmonary tuberculosis, late-onset lupus erythematosus with lupus nephritis, and a positive result for neutrophil cytoplasmic antibody. An immune-mediated extracapillary proliferative glomerulonephritis was found when the biopsy was performed, with obvious signs of vasculitis, an overlap syndrome was found between these entities. She was initially treated with antituberculosis therapy, boluses of methylprednisolone and continued with intermittent renal replacement therapy; however, due to the severity of his pathologies, she had a fatal outcome. Te concomitance between these autoimmune pathologies is unusual; there is a late-onset overlap syndrome between lupus nephritis accompanied by myeloperoxidase-antineutrophil cytoplasmic antibody and pauci-immune glomerulonephritis. Te dual presentation es tablishes clinical challeng.pdfengAttribution-NonCommercial-NoDerivs 3.0 United StatesANCAinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://doi.org/10.1155/crin/5285961https://onlinelibrary.wiley.com/doi/full/10.1155/crin/5285961ANCAANCA-associated vasculitisAntibodiesAntineutrophil cytoplasmicGlomerulonephritisErythematosusLupus nephritisMPOMyeloperoxidaseSystemicVasculitis