Inhibidores de la proteína HSP90
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Fecha
2026
Autores
Osorio De La Barrera, Pedro Luis
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias Básicas y Biomédicas
Facultad de Ciencias Básicas y Biomédicas
Resumen
El presente proyecto de investigación se enfocó en el análisis de la interacción entre flavonoides naturales con reconocidas propiedades antioxidantes y anticancerígenas, y la proteína de choque térmico HSP90, una chaperona molecular clave en la progresión y supervivencia celular de diversos tipos de cáncer. La pertinencia del estudio radica en la búsqueda de nuevas estrategias terapéuticas más seguras y efectivas a partir de compuestos naturales, frente a la alta tasa de mortalidad y resistencia al tratamiento convencional que caracteriza al cáncer. El problema central abordó la necesidad de comprender con mayor profundidad el mecanismo molecular de inhibición de la HSP90 por compuestos naturales. Para ello, se emplearon técnicas de análisis molecular y modelado computacional que permitieron identificar los sitios de unión más relevantes y evaluar la afinidad y estabilidad de la interacción molecular. La introducción se sustentó en la función crucial de la HSP90 en la estabilización de proteínas asociadas al crecimiento tumoral y en la evidencia que sustenta a la quercetina como un inhibidor natural de esta proteína, destacando su potencial para promover la apoptosis selectiva en células cancerosas sin afectar las células normales. El estudio contribuyó a la farmacología moderna al explorar compuestos naturales alternativos a los inhibidores sintéticos, que suelen presentar toxicidad y efectos secundarios adversos.
This research project focused on analyzing the interaction between natural flavonoids with recognized antioxidant and anticancer properties and the heat shock protein HSP90, a key molecular chaperone in the progression and cell survival of various types of cancer. The relevance of the study lies in the search for new, safer, and more effective therapeutic strategies based on natural compounds, given the high mortality rate and resistance to conventional treatment that characterize cancer. The central problem addressed the need to understand in greater depth the molecular mechanism of HSP90 inhibition by natural compounds. To this end, molecular analysis and computational modeling techniques were used to identify the most relevant binding sites and evaluate the affinity and stability of the molecular interaction. The introduction was based on the crucial role of HSP90 in stabilizing proteins associated with tumor growth and on the evidence supporting quercetin as a natural inhibitor of this protein, highlighting its potential to promote selective apoptosis in cancer cells without affecting normal cells. The study contributed to modern pharmacology by exploring natural compounds as alternatives to synthetic inhibitors, which often present toxicity and adverse side effects.
This research project focused on analyzing the interaction between natural flavonoids with recognized antioxidant and anticancer properties and the heat shock protein HSP90, a key molecular chaperone in the progression and cell survival of various types of cancer. The relevance of the study lies in the search for new, safer, and more effective therapeutic strategies based on natural compounds, given the high mortality rate and resistance to conventional treatment that characterize cancer. The central problem addressed the need to understand in greater depth the molecular mechanism of HSP90 inhibition by natural compounds. To this end, molecular analysis and computational modeling techniques were used to identify the most relevant binding sites and evaluate the affinity and stability of the molecular interaction. The introduction was based on the crucial role of HSP90 in stabilizing proteins associated with tumor growth and on the evidence supporting quercetin as a natural inhibitor of this protein, highlighting its potential to promote selective apoptosis in cancer cells without affecting normal cells. The study contributed to modern pharmacology by exploring natural compounds as alternatives to synthetic inhibitors, which often present toxicity and adverse side effects.
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Palabras clave
HSP90, Compuestos naturales, Quercetina, Docking molecular, Inhibición molecular, Cancer
