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dc.contributor.advisorNavarro, Elkin
dc.contributor.authorVera Tapias, David Jair
dc.contributor.authorLopez Molina, Camilo Jose
dc.contributor.authorOrozco Montaño, Daniela
dc.date.accessioned2021-07-26T18:57:11Z
dc.date.available2021-07-26T18:57:11Z
dc.date.issued2020-12
dc.identifier.urihttps://hdl.handle.net/20.500.12442/8050
dc.description.abstractLa pandemia de COVID-19 nos ha llevado a muchos a quedarnos en casa, donde mantenemos menos interacciones sociales y hacemos menos ejercicio. Esto puede tener consecuencias negativas para la salud física y mental. A continuación ofrecemos recomendaciones para que usted y su familia se mantengan sanos en casa durante este periodo de confinamiento. La enfermedad causada por el nuevo coronavirus (COVID-19) se caracteriza por presentar fiebre y tos, afectar el tracto respiratorio inferior y estar asociada con la edad, comorbilidades y un sistema inmune debilitado. Típicamente se ha evidenciado linfopenias en los casos graves y una desmedida producción de citocinas inflamatorias (tormenta de citocinas), lo que explicaría el rol de la respuesta hiperinflamatoria en la patogénesis de la COVID-19. Las respuestas inflamatorias secundarias por reinfecciones del virus podrían inducir el aumento o la mejora dependiente de anticuerpos (ADE, por sus siglas en inglés), un fenómeno virémico que podría ser un mecanismo alternativo de infección celular y que se deberá tener en cuenta cuando se diseñen vacunas o inmunoterapias que involucren el estímulo de anticuerpos neutralizantes o el uso de anticuerpos monoclonales. Actualmente no existen vacunas ni tratamientos que demuestren seguridad y eficacia en pacientes con COVID-19; sin embargo, se espera la conclusión de los resultados de la aplicación de una vacuna de ácidos nucleicos ARNm (mensajero del ácido ribonucleico) y de un fármaco antiviral (remdisivir) que se encuentran en ensayos clínicos fase III. Por el momento la mejor medida para evitar la propagación de la infección es el aislamiento social exhaustivo y viene siendo adoptado por varios países según recomendación de la Organización Mundial de la Salud (OMS).spa
dc.description.abstractThe COVID-19 pandemic has led many of us to stay at home, where we have fewer social interactions and exercise less. This can have negative consequences for physical and mental health. Here are some tips to help you and your family stay healthy at home during this period of confinement. The disease caused by the new coronavirus (COVID-19) is characterized by fever and cough, affecting the lower respiratory tract and being associated with age, comorbidities and a weakened immune system. Lymphopenias has typically been evidenced in severe cases and excessive production of inflammatory cytokines (cytokine storm), which would explain the role of the hyperinflammatory response in the pathogenesis of COVID-19. Secondary inflammatory responses due to virus reinfections could induce antibody-dependent enhancement or enhancement (ADE), a viremic phenomenon that could be an alternative mechanism of cellular infection and that should be taken into account when designing vaccines or immunotherapies that involve the stimulation of neutralizing antibodies or the use of monoclonal antibodies. Currently there are no vaccines or treatments that demonstrate safety and efficacy in patients with COVID-19; however, the results of the application of an mRNA nucleic acid vaccine (ribonucleic acid messenger) and an antiviral drug (remdisivir), which are in phase III clinical trials, are awaited. At the moment, the best measure to prevent the spread of the infection is exhaustive social isolation and it has been adopted by several countries according to the recommendation of the World Health Organization (WHO).eng
dc.format.mimetypepdfspa
dc.language.isospaspa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad de Ciencias de la Saludspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSíndrome respiratorio agudo gravespa
dc.subjectNeumonía viralspa
dc.subjectVirosisspa
dc.subjectInfecciones por coronavirusspa
dc.subjectPandemiasspa
dc.subjectAnticuerposspa
dc.subjectCitocinasspa
dc.subjectLinfocitosspa
dc.subjectVacunasspa
dc.subjectCOVID-19spa
dc.subjectSevere acute respiratory syndromeeng
dc.subjectViral pneumoniaeng
dc.subjectVirosiseng
dc.subjectCoronavirus infectionseng
dc.subjectPandemicseng
dc.subjectAntibodieseng
dc.subjectCytokineseng
dc.subjectLymphocyteseng
dc.subjectVaccineseng
dc.subjectCOVID-19eng
dc.titleAnálisis del proceso inflamatorio en Covid -19spa
dcterms.referencesCentro Nacional de Epidemiología Prevención y Control de Enfermedades - MINSA. Sala situacional COVID-19 Perú [Internet]. 2020 [citado el 17 de abril de 2020]. p. 1. Disponible en: https://covid19.minsa.gob.pe/sala_situacional.asp » https://covid19.minsa.gob.pe/sala_situacional.aspspa
dcterms.referencesGao QY, Chen YX, Fang JY. 2019 Novel coronavirus infection and gastrointestinal tract. J Dig Dis. 2020;21:125-6.eng
dcterms.referencesDeBiasi RL, Song X, Delaney M, Bell M, Smith K, Pershad J,et al. Severe COVID-19 in children and young adults in the Washington, D. C.: Metropolitan Region. J Pediatr. 2020;(20):30581-3.eng
dcterms.referencesHolman RC, Belay ED, Christensen KY, Folkema AM, Steiner CA, Schonberger LB, et al. Hospitalizations for Kawasaki syndrome among children in the United States, 1997-2007. Pediatr Infect Dis J. 2010;29:483eng
dcterms.referencesHuang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. » https://doi.org/10.1016/S0140-6736(20)30183-5eng
dcterms.referencesJones VG, Mills M, Suárez D, Hogan CA, Yeh D, Segal B,et al. COVID-19 and Kawasaki Disease: Novel virus and novel case. Hosp Pediatr. 2020;10(6):537-40.eng
dcterms.referencesMahase E. Covid-19: Cases of inflammatory syndrome in children surge after urgent alert. BMJ. 2020;369:1990.eng
dcterms.referencesMcCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF,Gewitz M, et al. Diagnosis, treatment, and long-term managementof Kawasaki disease: A scientific statement for health professionals from the American Heart Association. Circulation. 2017;135:e927-99.eng
dcterms.referencesSarzi-Puttini P, Giorgi V, Sirotti S, Marotto D, Ardizzone S, Rizzardini G, et al. COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome?. Clin Exp Rheumatol. 2020;38(2):337-42.eng
dcterms.referencesSarzi-Puttini P, Giorgi V, Sirotti S, Marotto D, Ardizzone S, Rizzardini G, et al. COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome?. Clin Exp Rheumatol. 2020;38(2):345-*2eng
dcterms.referencesShanmugaraj B, Siriwattananon K, Wangkanont K, Phoolcharoen W. Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19). Asian Pac J Allergy Immunol. 2020;10-8. doi: 10.12932/AP-200220-0773. » https://doi.org/10.12932/AP-200220-0773.eng
dcterms.referencesQin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. J Chem Inf Model. 2020; doi: 10.1093/cid/ciaa248. [Epub ahead of print]. » https://doi.org/10.1093/cid/ciaa248eng
dcterms.referencesVerdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italianepicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771.eng
dcterms.referencesWHO. World Health Organization [Internet]. Situation reports 87. 2020 [citado el 16 de abril de 2020]. p. 1. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reportseng
dcterms.referencesWang F, Nie J, Wang H, Qiu Z, Yong X, Liping D, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020; doi: 10.1093/infdis/jiaa150. [Epub ahead of print]. » https://doi.org/10.1093/infdis/jiaa150eng
dcterms.referencesWu D, Yang XO. TH17 Responses in Cytokine Storm of COVID-19: An Emerging Target of JAK2 Inhibitor Fedratinib. J Microbiol Immunol Infect. 2020; doi: 10.1016/j.jmii.2020.03.005. 17. » https://doi.org/10.1016/j.jmii.2020.03.005eng
dcterms.referencesWu Y, Ho W, Huang Y, Jin DY, Li S, Liu SL, et al.SARS-CoV-2 is an appropriate name for the new coronavirus. Lancet .2020;395(10228):949-50.eng
dcterms.referencesXu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir Med. 2020;8(4):420-2.eng
dcterms.referencesRiphagen S, Gomez X, González-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020; 395:1607.eng
dcterms.referencesXiong Y, Liu Y, Cao L, Wang D, Guo M, Guo D, et al. Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients. Emerg Microbes Infect. 2020;9(1):761-70. doi: 10.1080/22221751.2020.1747363. » https://doi.org/10.1080/22221751.2020.1747363.eng
dcterms.referencesXiong Y, Liu Y, Cao L, Wang D, Guo M, Guo D, et al. Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients. Emerg Microbes Infect. 2020;9(1):761-70. doi: 10.1080/22221751.2020.1747363. » https://doi.org/10.1080/22221751.2020.1747363eng
dcterms.referencesXu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;2600(20):19-21. doi: 10.1016/S2213-2600(20)30076-X. » https://doi.org/10.1016/S2213-2600(20)30076-X.eng
dcterms.referencesZou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med [Internet]. 2020;1-8. doi: 10.1007/s11684-020-0754-0. » https://doi.org/10.1007/s11684-020-0754-0.eng
sb.sedeSede Barranquillaspa
sb.programaMedicinaspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccesseng
datacite.rightshttp://purl.org/coar/access_right/c_16eceng
oaire.versioninfo:eu-repo/semantics/acceptedVersioneng
dc.type.driverinfo:eu-repo/semantics/bachelorThesiseng
dc.type.spaTrabajo de grado - pregradospa


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